Protein: KITH
Thymidine kinase, cytosolic (EC 2.7.1.21)

Gene: KITH, TK1
Organism: Homo sapiens
Interactions: 242
UniProt ID: P04183

Gene Ontology (top 5):
GO:0004797 - thymidine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006139 - nucleobase-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

405370

KITH
Thymidine kinase, cytosolic

2

9

Small-scale

0.781

High

405560

FZR1
Fizzy-related protein homolog

7

1

Small-scale

0.751

High

405373

P53
Cellular tumor antigen p53

3

0

High-throughput

0.634

High

405420

CRIP1
Cysteine-rich protein 1

2

1

High-throughput

0.628

High

405439

TLE1
Transducin-like enhancer protein 1

2

1

High-throughput

0.620

High

405455

TBB2A
Tubulin beta-2A chain

2

1

High-throughput

0.620

High

405463

SETB1
Histone-lysine N-methyltransferase SETDB1

2

1

High-throughput

0.620

High

405375

A4
Amyloid-beta precursor protein

2

1

High-throughput

0.611

High

405432

NCS1
Neuronal calcium sensor 1

2

0

High-throughput

0.602

High

405372

G3P
Glyceraldehyde-3-phosphate dehydrogenase

2

0

High-throughput

0.594

High

405449

U119A
Protein unc-119 homolog A

2

0

High-throughput

0.594

High

405457

DPYL1
Dihydropyrimidinase-related protein 1

2

0

High-throughput

0.594

High

405496

CSN6
COP9 signalosome complex subunit 6

2

0

High-throughput

0.594

High

405388

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.583

High

405413

MAGA4
Melanoma-associated antigen 4

2

1

High-throughput

0.576

High

405401

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.575

High

405421

APLP1
Amyloid beta precursor like protein 1

2

1

High-throughput

0.566

High

159461

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

0

High-throughput

0.559

High

405497

MAMC2
MAM domain-containing protein 2

2

1

High-throughput

0.558

High

405464

KPCD1
Serine/threonine-protein kinase D1

2

0

High-throughput

0.547

High

405409

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.537

High

405534

ANM1
Protein arginine N-methyltransferase 1

1

0

Small-scale

0.537

High

326396

ZN202
Zinc finger protein 202

1

1

High-throughput

0.536

High

405390

NCF1
Neutrophil cytosol factor 1

1

1

High-throughput

0.536

High

405399

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.536

High

405541

BTBD1
BTB/POZ domain-containing protein 1

1

2

High-throughput

0.536

High

405563

ZN232
Zinc finger protein 232

1

1

High-throughput

0.536

High

405459

NC2A
Dr1-associated corepressor

1

0

High-throughput

0.518

High

405522

KAT5
Histone acetyltransferase KAT5

1

1

High-throughput

0.515

High

384601

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.513

High

405479

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.513

High

405503

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

405558

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.513

High

156581

DC1I1
Cytoplasmic dynein 1 intermediate chain 1

1

1

High-throughput

0.508

High

269430

KI21B
Kinesin-like protein KIF21B

1

1

High-throughput

0.508

High

280388

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

1

High-throughput

0.508

High

317306

ACL6B
Actin-like protein 6B

1

1

High-throughput

0.508

High

344848

WIZ
Protein Wiz

1

1

High-throughput

0.508

High

405379

TNR16
Tumor necrosis factor receptor superfamily member 16

1

1

High-throughput

0.508

High

405402

PTN4
Tyrosine-protein phosphatase non-receptor type 4

1

1

High-throughput

0.508

High

405408

VATA
V-type proton ATPase catalytic subunit A

1

1

High-throughput

0.508

High

405411

ACTY
Beta-centractin

1

1

High-throughput

0.508

High

405424

CRIP2
Cysteine-rich protein 2

1

1

High-throughput

0.508

High

405427

SUMO3
Small ubiquitin-related modifier 3

1

1

High-throughput

0.508

High

405440

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

High-throughput

0.508

High

405443

RBBP4
Histone-binding protein RBBP4

1

1

High-throughput

0.508

High

405446

KIF5A
Kinesin heavy chain isoform 5A

1

1

High-throughput

0.508

High

405451

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.508

High

405475

ZXDC
Zinc finger protein ZXDC

1

1

High-throughput

0.508

High

405488

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

1

High-throughput

0.508

High

405498

TRI46
Tripartite motif-containing protein 46

1

1

High-throughput

0.508

High

405499

MET23
Histone-arginine methyltransferase METTL23

1

1

High-throughput

0.508

High

405501

TIAM2
Rho guanine nucleotide exchange factor TIAM2

1

1

High-throughput

0.508

High

405510

A16L2
Protein Atg16l2

1

1

High-throughput

0.508

High

405519

DC2I1
Cytoplasmic dynein 2 intermediate chain 1

1

1

High-throughput

0.508

High

405532

KLHL5
Kelch-like protein 5

1

1

High-throughput

0.508

High

405536

PAAF1
Proteasomal ATPase-associated factor 1

1

1

High-throughput

0.508

High

405547

SP110
Sp110 nuclear body protein

1

2

High-throughput

0.508

High

405561

KMT2B
Histone-lysine N-methyltransferase 2B

1

1

High-throughput

0.508

High

405431

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.501

High

405445

CDC20
Cell division cycle protein 20 homolog

1

2

Small-scale

0.501

High

405529

CCD43
Coiled-coil domain-containing protein 43

1

0

High-throughput

0.493

High

405386

CADH1
Cadherin-1

1

1

High-throughput

0.489

High

405490

KLH24
Kelch-like protein 24

1

2

High-throughput

0.489

High

176017

KDM6B
Lysine-specific demethylase 6B

1

0

High-throughput

0.486

High

223973

GET3
ATPase GET3

1

0

High-throughput

0.486

High

251416

NMT2
Glycylpeptide N-tetradecanoyltransferase 2

1

0

High-throughput

0.486

High

295066

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.486

High

389915

ALBU
Albumin

1

0

High-throughput

0.486

High

405377

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

0

High-throughput

0.486

High

405378

CENPB
Major centromere autoantigen B

1

0

High-throughput

0.486

High

405382

ST1A4
Sulfotransferase 1A4

1

0

High-throughput

0.486

High

405384

CDK4
Cyclin-dependent kinase 4

1

0

High-throughput

0.486

High

405385

DCOR
Ornithine decarboxylase

1

0

High-throughput

0.486

High

405387

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

0

High-throughput

0.486

High

405391

KPYM
Pyruvate kinase PKM

1

0

High-throughput

0.486

High

405392

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.486

High

405396

RXRA
Retinoic acid receptor RXR-alpha

1

0

High-throughput

0.486

High

405400

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.486

High

405404

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

0

High-throughput

0.486

High

405405

GDIA
Rab GDP dissociation inhibitor alpha

1

0

High-throughput

0.486

High

405407

ADDA
Alpha-adducin

1

0

High-throughput

0.486

High

405412

MSH2
DNA mismatch repair protein Msh2

1

0

High-throughput

0.486

High

405414

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.486

High

405417

SYQ
Glutamine--tRNA ligase

1

0

High-throughput

0.486

High

405419

TSC2
Tuberin

1

0

High-throughput

0.486

High

405425

ATX3
Ataxin-3

1

0

High-throughput

0.486

High

405428

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.486

High

405429

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.486

High

405430

ACTB
Actin, cytoplasmic 1

1

0

High-throughput

0.486

High

405434

TYB4
Thymosin beta-4

1

0

High-throughput

0.486

High

405437

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.486

High

405441

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.486

High

405442

DMPK
Myotonin-protein kinase

1

0

High-throughput

0.486

High

405444

HMGX3
HMG domain-containing protein 3

1

0

High-throughput

0.486

High

405447

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.486

High

405452

SNX1
Sorting nexin-1

1

0

High-throughput

0.486

High

405454

AAMP
Angio-associated migratory cell protein

1

0

High-throughput

0.486

High

405458

IF4A2
Eukaryotic initiation factor 4A-II

1

0

High-throughput

0.486

High

405467

JHD2C
Probable JmjC domain-containing histone demethylation protein 2C

1

0

High-throughput

0.486

High

405468

NDF2
Neurogenic differentiation factor 2

1

0

High-throughput

0.486

High

405469

ITSN1
Intersectin-1

1

0

High-throughput

0.486

High

405470

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.486

High

405476

DALD3
DALR anticodon-binding domain-containing protein 3

1

0

High-throughput

0.486

High

405481

INT11
Integrator complex subunit 11

1

0

High-throughput

0.486

High

405484

MYOME
Myomegalin

1

0

High-throughput

0.486

High

405487

JADE1
Protein Jade-1

1

0

High-throughput

0.486

High

405494

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.486

High

405504

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.486

High

405505

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.486

High

405508

TRM2A
tRNA

1

0

High-throughput

0.486

High

405509

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

1

0

High-throughput

0.486

High

405513

FAD1
FAD synthase

1

0

High-throughput

0.486

High

405517

ZN431
Zinc finger protein 431

1

0

High-throughput

0.486

High

405537

INP5K
Inositol polyphosphate 5-phosphatase K

1

0

High-throughput

0.486

High

405548

GPCP1
Glycerophosphocholine phosphodiesterase GPCPD1

1

0

High-throughput

0.486

High

405549

DCA13
DDB1- and CUL4-associated factor 13

1

0

High-throughput

0.486

High

405551

DUS2
tRNA-dihydrouridine(20) synthase [NAD(P)+]-like

1

0

High-throughput

0.486

High

405552

DACT1
Dapper homolog 1

1

0

High-throughput

0.486

High

405557

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.486

High

405562

FAF1
FAS-associated factor 1

1

0

High-throughput

0.486

High

405564

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

0

High-throughput

0.486

High

405565

RUVB1
RuvB-like 1

1

0

High-throughput

0.486

High

405566

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.486

High

405568

MED31
Mediator of RNA polymerase II transcription subunit 31

1

0

High-throughput

0.486

High

405415

BAG6
Large proline-rich protein BAG6

1

1

High-throughput

0.481

High

405381

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

405514

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

Small-scale

0.480

High

405416

YAP1
Transcriptional coactivator YAP1

1

1

High-throughput

0.479

High

405418

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.479

High

405423

ZN131
Zinc finger protein 131

1

1

High-throughput

0.479

High

405448

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

405493

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

405511

ZBT38
Zinc finger and BTB domain-containing protein 38

1

1

Small-scale

0.479

High

405515

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

405521

KAT6A
Histone acetyltransferase KAT6A

1

1

High-throughput

0.479

High

405556

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

85939

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

1

High-throughput

0.470

High

405473

Q1RN33
Melanoma antigen A 4

1

1

High-throughput

0.470

High

405374

SCG1
Secretogranin-1

1

1

High-throughput

0.464

High

405380

CO4A2

1

2

High-throughput

0.464

High

405389

COBA2

1

1

High-throughput

0.464

High

405403

CO4A5

1

2

High-throughput

0.464

High

405422

PLXA3
Plexin-A3

1

1

High-throughput

0.464

High

405462

HERC3
Probable E3 ubiquitin-protein ligase HERC3

1

1

High-throughput

0.464

High

405512

KLH23
Kelch-like protein 23

1

2

High-throughput

0.464

High

405538

WDR18
WD repeat-containing protein 18

1

2

High-throughput

0.464

High

405543

BOLA2
BolA-like protein 2

1

0

High-throughput

0.460

High

405545

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.460

High

131653

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

0

High-throughput

0.458

High

240458

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

293034

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

370892

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

405393

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

405398

CCND1
G1/S-specific cyclin-D1

1

0

High-throughput

0.458

High

405410

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

405433

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

405435

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.458

High

405436

1433Z
14-3-3 protein zeta/delta

1

0

High-throughput

0.458

High

405450

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

405453

CUL3
Cullin-3

1

0

High-throughput

0.458

High

405460

CUL7
Cullin-7

1

0

High-throughput

0.458

High

405461

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

405485

MYSM1
Deubiquitinase MYSM1

1

0

Small-scale

0.458

High

405486

TENS2
Tensin-2

1

0

High-throughput

0.458

High

405550

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

405555

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

142267

PEX7
Peroxisomal targeting signal 2 receptor

1

1

High-throughput

0.445

High

258715

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.445

High

405506

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.445

High

405483

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

217697

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

273806

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.426

High

326877

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

405383

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.426

High

405533

MPH6
M-phase phosphoprotein 6

1

0

High-throughput

0.426

High

379483

IGHM
Immunoglobulin heavy constant mu

1

1

High-throughput

0.417

High

405492

CREL2
Protein disulfide isomerase CRELD2

1

1

High-throughput

0.417

High

405524

EMID1
EMI domain-containing protein 1

1

2

High-throughput

0.407

High

128577

AGRP
Agouti-related protein

3

0

High-throughput

0.345

High

248376

GDF9
Growth/differentiation factor 9

2

0

High-throughput

0.323

High

405465

PTPRK
Receptor-type tyrosine-protein phosphatase kappa

2

0

High-throughput

0.323

High

405478

RBM48
RNA-binding protein 48

2

0

High-throughput

0.323

High

405540

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

2

0

High-throughput

0.323

High

405559

ERG28
Ergosterol biosynthetic protein 28 homolog

2

0

High-throughput

0.323

High

405546

TNR27
Tumor necrosis factor receptor superfamily member 27

2

0

High-throughput

0.318

High

405480

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

High-throughput

0.310

High

405491

SE6L2
Seizure 6-like protein 2

1

0

High-throughput

0.282

High

192054

PA2GX
Group 10 secretory phospholipase A2

1

0

High-throughput

0.279

Low

388876

FINC
Fibronectin

1

0

High-throughput

0.279

Low

405482

MEI1
Meiosis inhibitor protein 1

1

0

High-throughput

0.279

Low

405507

P20D2
Xaa-Arg dipeptidase

1

0

High-throughput

0.279

Low

405573

KCMB2
Calcium-activated potassium channel subunit beta-2

1

0

High-throughput

0.279

Low

752

A0A087WZT3
BOLA2-SMG1P6 readthrough

1

0

High-throughput

0.268

Low

190697

MPPD1
Metallophosphoesterase domain-containing protein 1

1

0

High-throughput

0.265

Low

343520

CPNE6
Copine-6

1

0

High-throughput

0.265

Low

350271

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.265

Low

361681

F13A
Coagulation factor XIII A chain

1

0

High-throughput

0.265

Low

369576

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.265

Low

387771

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

0

High-throughput

0.265

Low

402465

PROC
Vitamin K-dependent protein C

1

0

High-throughput

0.265

Low

405371

A1BG
Alpha-1B-glycoprotein

1

0

High-throughput

0.265

Low

405376

TETN
Tetranectin

1

0

High-throughput

0.265

Low

405394

BGAL
Beta-galactosidase

1

0

High-throughput

0.265

Low

405397

FST
Follistatin

1

0

High-throughput

0.265

Low

405426

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.265

Low

405438

EM55
55 kDa erythrocyte membrane protein

1

0

High-throughput

0.265

Low

405456

SEPT6
Septin-6

1

0

High-throughput

0.265

Low

405466

TAF1C
TATA box-binding protein-associated factor RNA polymerase I subunit C

1

0

High-throughput

0.265

Low

405472

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.265

Low

405477

TTC38
Tetratricopeptide repeat protein 38

1

0

High-throughput

0.265

Low

405489

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.265

Low

405495

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

0

High-throughput

0.265

Low

405500

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.265

Low

405516

ABHD4
(Lyso)-N-acylphosphatidylethanolamine lipase

1

0

High-throughput

0.265

Low

405520

DYT2B
Dynein light chain Tctex-type protein 2B

1

0

High-throughput

0.265

Low

405523

EXT2
Exostosin-2

1

0

High-throughput

0.265

Low

405525

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.265

Low

405526

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.265

Low

405527

THOC3
THO complex subunit 3

1

0

High-throughput

0.265

Low

405530

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.265

Low

405531

VMA22
Vacuolar ATPase assembly protein VMA22

1

0

High-throughput

0.265

Low

405535

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.265

Low

405539

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.265

Low

405542

ATS10
A disintegrin and metalloproteinase with thrombospondin motifs 10

1

0

High-throughput

0.265

Low

405553

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

0

High-throughput

0.265

Low

405554

SEM5B
Semaphorin-5B

1

0

High-throughput

0.265

Low

405570

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.265

Low

405571

CSAD
Cysteine sulfinic acid decarboxylase

1

0

High-throughput

0.265

Low

405572

MOFA1
MORF4 family-associated protein 1

1

0

High-throughput

0.265

Low

405406

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

405474

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.249

Low

405528

RHOV
Rho-related GTP-binding protein RhoV

1

0

High-throughput

0.249

Low

405544

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

405567

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

76321

B4DNA4
HCG20425, isoform CRA_a

1

0

High-throughput

0.238

Low

405502

U2D2L
Putative ubiquitin-conjugating enzyme E2 D2-like protein

1

0

High-throughput

0.238

Low

405395

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

405471

TPD53
Tumor protein D53

1

0

High-throughput

0.232

Low

405518

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.232

Low

405569

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025