Protein: CCN2
CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8)

Gene: CCN2
Organism: Homo sapiens
Interactions: 51
UniProt ID: P29279

Gene Ontology (top 5):
GO:0001502 - cartilage condensation
GO:0001503 - ossification
GO:0001525 - angiogenesis
GO:0001894 - tissue homeostasis
GO:0002062 - chondrocyte differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

709292

LRP2
Low-density lipoprotein receptor-related protein 2

2

4

High-throughput

0.628

High

709294

EP300
Histone acetyltransferase p300

2

1

High-throughput

0.628

High

709297

TRI68
E3 ubiquitin-protein ligase TRIM68

2

1

High-throughput

0.628

High

709304

CBP
CREB-binding protein

2

1

High-throughput

0.628

High

395546

ESR1
Estrogen receptor

1

1

Small-scale

0.594

High

389066

FINC
Fibronectin

1

2

Small-scale

0.586

High

709303

ESR2
Estrogen receptor beta

1

1

Small-scale

0.581

High

709306

VWCE
von Willebrand factor C and EGF domain-containing protein

1

11

High-throughput

0.575

High

709290

ACTB
Actin, cytoplasmic 1

1

0

Small-scale

0.561

High

585437

VEGFA
Vascular endothelial growth factor A, long form

1

0

Small-scale

0.537

High

709287

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

0

High-throughput

0.518

High

641123

FGFR2
Fibroblast growth factor receptor 2

1

1

Small-scale

0.501

High

650059

FGFR3
Fibroblast growth factor receptor 3

1

1

Small-scale

0.501

High

654472

FBLN1
Fibulin-1

1

9

Small-scale

0.501

High

709289

MMP14
Matrix metalloproteinase-14

1

2

Small-scale

0.501

High

709316

ARI1
E3 ubiquitin-protein ligase ARIH1

1

1

High-throughput

0.489

High

217864

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

362823

EGFR
Epidermal growth factor receptor

1

1

Small-scale

0.479

High

590813

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.479

High

709288

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

709309

ACE2
Angiotensin-converting enzyme 2

1

1

High-throughput

0.479

High

709312

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

709291

FBLN2
Fibulin-2

1

9

High-throughput

0.445

High

709293

NOTC2
Neurogenic locus notch homolog protein 2

1

4

High-throughput

0.445

High

709307

EGFL8
Epidermal growth factor-like protein 8

1

6

High-throughput

0.445

High

709311

FBLN5
Fibulin-5

1

8

High-throughput

0.445

High

709313

EGFL7
Epidermal growth factor-like protein 7

1

5

High-throughput

0.445

High

709314

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

1

2

High-throughput

0.445

High

192450

INSI1
Insulin-induced gene 1 protein

1

2

High-throughput

0.437

High

371246

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

709317

INSI2
Insulin-induced gene 2 protein

1

2

High-throughput

0.437

High

167439

WNT9A
Protein Wnt-9a

1

0

High-throughput

0.426

High

190315

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.426

High

224467

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.426

High

482674

SPRC
SPARC

1

0

High-throughput

0.426

High

552918

PIP
Prolactin-inducible protein

1

0

High-throughput

0.426

High

570651

EDN3
Endothelin-3

1

0

High-throughput

0.426

High

709286

CDD
Cytidine deaminase

1

0

High-throughput

0.426

High

709301

PATE1
Prostate and testis expressed protein 1

1

0

High-throughput

0.426

High

709310

DKK3
Dickkopf-related protein 3

1

0

High-throughput

0.426

High

709300

KLH23
Kelch-like protein 23

2

0

High-throughput

0.328

High

709305

COA7
Cytochrome c oxidase assembly factor 7

2

0

High-throughput

0.328

High

709315

FZR1
Fizzy-related protein homolog

2

0

High-throughput

0.328

High

709302

RSPH1
Radial spoke head 1 homolog

1

0

High-throughput

0.282

High

592992

ACADS
Short-chain specific acyl-CoA dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

709296

CD017
Uncharacterized protein C4orf17

1

0

High-throughput

0.269

Low

341900

CEP43
Centrosomal protein 43

1

0

Small-scale

0.261

Low

709295

EEA1
Early endosome antigen 1

1

0

High-throughput

0.249

Low

709298

EPHX4
Epoxide hydrolase 4

1

0

High-throughput

0.232

Low

709299

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.232

Low

709308

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025