Protein: 5HT2C
5-hydroxytryptamine receptor 2C (5-HT-2C) (5-HT2C) (5-HTR2C) (5-hydroxytryptamine receptor 1C) (5-HT-1C) (5-HT1C) (Serotonin receptor 2C)

Gene: 5HT2C, HTR2C
Organism: Homo sapiens
Interactions: 134
UniProt ID: P28335

Gene Ontology (top 5):
GO:0001587 - Gq/11-coupled serotonin receptor activity
GO:0001662 - behavioral fear response
GO:0004993 - G protein-coupled serotonin receptor activity
GO:0005886 - plasma membrane
GO:0006874 - intracellular calcium ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658209

5HT2C
5-hydroxytryptamine receptor 2C

3

17

Small-scale

0.827

High

658233

MTR1L
Melatonin-related receptor

2

18

High-throughput

0.811

High

656988

5HT2A
5-hydroxytryptamine receptor 2A

2

17

Small-scale

0.743

High

176002

GPR37
Prosaposin receptor GPR37

1

20

High-throughput

0.698

High

658220

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.691

High

658297

RTN4
Reticulon-4

3

5

High-throughput

0.678

High

280022

MPDZ
Multiple PDZ domain protein

3

20

Small-scale

0.672

High

658288

TM147
BOS complex subunit TMEM147

4

0

High-throughput

0.669

High

658304

S39A1
Zinc transporter ZIP1

2

11

High-throughput

0.633

High

415215

ATPB
ATP synthase subunit beta, mitochondrial

2

6

High-throughput

0.628

High

572289

LEG3
Galectin-3

2

1

High-throughput

0.628

High

658210

HMOX2
Heme oxygenase 2

2

1

High-throughput

0.628

High

658219

ACTA
Actin, aortic smooth muscle

2

5

High-throughput

0.628

High

658222

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

9

High-throughput

0.628

High

658224

CAV1
Caveolin-1

2

4

High-throughput

0.628

High

658244

LMBD2
G-protein coupled receptor-associated protein LMBRD2

2

2

High-throughput

0.628

High

658258

LRC8A
Volume-regulated anion channel subunit LRRC8A

2

4

High-throughput

0.628

High

658296

GPC5C
G-protein coupled receptor family C group 5 member C

2

8

High-throughput

0.628

High

658299

SERC1
Serine incorporator 1

2

2

High-throughput

0.628

High

658302

LIN7C
Protein lin-7 homolog C

2

20

Small-scale

0.619

High

658270

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.618

High

436896

ACM4
Muscarinic acetylcholine receptor M4

1

19

Small-scale

0.618

High

658211

5HT2B
5-hydroxytryptamine receptor 2B

1

17

Small-scale

0.618

High

658212

MTR1A
Melatonin receptor type 1A

1

16

Small-scale

0.618

High

658213

MTR1B
Melatonin receptor type 1B

1

16

Small-scale

0.618

High

658216

BI1
Bax inhibitor 1

2

4

High-throughput

0.606

High

658301

S39A9
Zinc transporter ZIP9

2

11

High-throughput

0.606

High

240869

S19A2
Thiamine transporter 1

2

0

High-throughput

0.602

High

658214

KNTC1
Kinetochore-associated protein 1

2

0

High-throughput

0.602

High

658266

S35G2
Solute carrier family 35 member G2

2

0

High-throughput

0.602

High

658268

CIP2A
Protein CIP2A

2

0

High-throughput

0.602

High

658215

EMP1
Epithelial membrane protein 1

2

0

High-throughput

0.580

High

658234

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

0

High-throughput

0.578

High

59734

KLRG2
Killer cell lectin-like receptor subfamily G member 2

2

5

High-throughput

0.574

High

234097

FADS1
Acyl-CoA

2

1

High-throughput

0.574

High

256729

CAND2
Cullin-associated NEDD8-dissociated protein 2

2

7

High-throughput

0.574

High

312188

IPO7
Importin-7

2

8

High-throughput

0.574

High

327135

CF047
Uncharacterized protein C6orf47

2

1

High-throughput

0.574

High

623200

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

2

1

High-throughput

0.574

High

658232

MTX1
Metaxin-1

2

1

High-throughput

0.574

High

658242

S35F1
Solute carrier family 35 member F1

2

1

High-throughput

0.574

High

658243

ECM29
Proteasome adapter and scaffold protein ECM29

2

6

High-throughput

0.574

High

658247

MBOA5
Lysophospholipid acyltransferase 5

2

3

High-throughput

0.574

High

658250

CERS6
Ceramide synthase 6

2

9

High-throughput

0.574

High

658255

UB2Q1
Ubiquitin-conjugating enzyme E2 Q1

2

1

High-throughput

0.574

High

658257

RETR3
Reticulophagy regulator 3

2

2

High-throughput

0.574

High

658259

S35F2
Solute carrier family 35 member F2

2

1

High-throughput

0.574

High

658260

CERS5
Ceramide synthase 5

2

9

High-throughput

0.574

High

658262

ARL10
ADP-ribosylation factor-like protein 10

2

7

High-throughput

0.574

High

658263

RETR2
Reticulophagy regulator 2

2

2

High-throughput

0.574

High

658265

GOGA5
Golgin subfamily A member 5

2

2

High-throughput

0.574

High

658275

TV23C
Golgi apparatus membrane protein TVP23 homolog C

2

2

High-throughput

0.574

High

658276

CERS2
Ceramide synthase 2

2

9

High-throughput

0.574

High

658294

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

2

High-throughput

0.574

High

658295

TM9S3
Transmembrane 9 superfamily member 3

2

3

High-throughput

0.574

High

658300

PDS5B
Sister chromatid cohesion protein PDS5 homolog B

2

2

High-throughput

0.574

High

658308

IPO11
Importin-11

2

7

High-throughput

0.574

High

658309

XPO7
Exportin-7

2

4

High-throughput

0.574

High

658312

ANGE1
Protein angel homolog 1

2

1

High-throughput

0.574

High

658314

TNPO3
Transportin-3

2

6

High-throughput

0.574

High

155535

TNPO2
Transportin-2

2

6

High-throughput

0.558

High

274940

RENR
Renin receptor

1

1

High-throughput

0.541

High

566933

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.541

High

648003

VATL
V-type proton ATPase 16 kDa proteolipid subunit c

1

2

High-throughput

0.541

High

658218

MYPR
Myelin proteolipid protein

1

1

High-throughput

0.541

High

658238

SGCB
Beta-sarcoglycan

1

1

High-throughput

0.541

High

658239

AT2B3
Plasma membrane calcium-transporting ATPase 3

1

10

High-throughput

0.541

High

658283

TM9S2
Transmembrane 9 superfamily member 2

1

3

High-throughput

0.541

High

658305

GPC5B
G-protein coupled receptor family C group 5 member B

1

8

High-throughput

0.541

High

217141

EXTL3
Exostosin-like 3

1

1

High-throughput

0.536

High

658230

S39A6
Zinc transporter ZIP6

1

11

High-throughput

0.536

High

658311

S39AA
Zinc transporter ZIP10

1

11

High-throughput

0.536

High

474445

GPHRB
Golgi pH regulator B

2

3

High-throughput

0.533

High

658284

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.518

High

658226

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

658231

ADAM9
Disintegrin and metalloproteinase domain-containing protein 9

1

0

High-throughput

0.513

High

658235

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.513

High

658272

CDS1
Phosphatidate cytidylyltransferase 1

1

0

High-throughput

0.513

High

81788

GPHRA
Golgi pH regulator A

2

3

High-throughput

0.504

High

658221

DLG4
Disks large homolog 4

1

18

Small-scale

0.501

High

658223

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

20

Small-scale

0.501

High

658227

DLG1
Disks large homolog 1

1

18

High-throughput

0.501

High

658236

SCRIB
Protein scribble homolog

1

20

High-throughput

0.501

High

658277

CREL1
Protein disulfide isomerase CRELD1

1

2

High-throughput

0.494

High

658279

MF14A
Hippocampus abundant transcript 1 protein

1

2

High-throughput

0.494

High

658292

SPNS1
Protein spinster homolog 1

1

1

High-throughput

0.494

High

658293

GHITM
Growth hormone-inducible transmembrane protein

1

4

High-throughput

0.494

High

213200

SNG2
Synaptogyrin-2

1

3

High-throughput

0.489

High

371263

ATP8
ATP synthase protein 8

1

1

High-throughput

0.489

High

658256

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

9

High-throughput

0.489

High

658264

MFSD8
Major facilitator superfamily domain-containing protein 8

1

3

High-throughput

0.489

High

658269

SFXN5
Sideroflexin-5

1

1

High-throughput

0.489

High

658274

F241B
Protein FAM241B

1

1

High-throughput

0.489

High

658280

MBOA7
Lysophospholipid acyltransferase 7

1

3

High-throughput

0.489

High

658281

IPO9
Importin-9

1

8

High-throughput

0.489

High

658285

CND3
Condensin complex subunit 3

1

1

High-throughput

0.489

High

658286

LRRC1
Leucine-rich repeat-containing protein 1

1

2

High-throughput

0.489

High

658298

EI2BG
Translation initiation factor eIF2B subunit gamma

1

1

High-throughput

0.489

High

658229

SNTA1
Alpha-1-syntrophin

1

20

Small-scale

0.481

High

658240

Q4LE60
TNPO2 variant protein

1

6

High-throughput

0.407

High

163567

BTAF1
TATA-binding protein-associated factor 172

2

0

High-throughput

0.328

High

182259

TPSN
Tapasin

2

0

High-throughput

0.328

High

658241

AG10A
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase

2

0

High-throughput

0.328

High

658245

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

2

0

High-throughput

0.328

High

658246

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.328

High

658248

PDXD1
Pyridoxal-dependent decarboxylase domain-containing protein 1

2

0

High-throughput

0.328

High

658251

TMPPE
Transmembrane protein with metallophosphoesterase domain

2

0

High-throughput

0.328

High

658252

D19L4
Probable C-mannosyltransferase DPY19L4

2

0

High-throughput

0.328

High

658254

HEAT3
HEAT repeat-containing protein 3

2

0

High-throughput

0.328

High

658261

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

0

High-throughput

0.328

High

658267

TBC15
TBC1 domain family member 15

2

0

High-throughput

0.328

High

658273

GLMN
Glomulin

2

0

High-throughput

0.328

High

658278

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.328

High

658282

RBM14
RNA-binding protein 14

2

0

High-throughput

0.328

High

658291

5NT3A
Cytosolic 5'-nucleotidase 3A

2

0

High-throughput

0.328

High

658303

RMND1
Required for meiotic nuclear division protein 1 homolog

2

0

High-throughput

0.328

High

658307

SEC63
Translocation protein SEC63 homolog

2

0

High-throughput

0.328

High

658313

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.328

High

313585

CNIH1
Protein cornichon homolog 1

2

0

High-throughput

0.316

High

658217

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.282

High

658225

TMM94
Transmembrane protein 94

1

0

High-throughput

0.282

High

658228

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.282

High

658271

CD003
Uncharacterized protein C4orf3

1

0

High-throughput

0.282

High

658310

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.282

High

176124

PPM1G
Protein phosphatase 1G

1

0

High-throughput

0.279

Low

503205

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.279

Low

658237

CND1
Condensin complex subunit 1

1

0

High-throughput

0.279

Low

658249

BRAT1
BRCA1-associated ATM activator 1

1

0

High-throughput

0.279

Low

658253

TRM11
tRNA

1

0

High-throughput

0.279

Low

658287

ALG8
Dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase

1

0

High-throughput

0.279

Low

658289

ITPA
Inosine triphosphate pyrophosphatase

1

0

High-throughput

0.279

Low

658290

DERL2
Derlin-2

1

0

High-throughput

0.279

Low

658306

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024