Protein: CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6 (Chemokine-like factor superfamily member 6)

Gene: CKLF6, CMTM6
Organism: Homo sapiens
Interactions: 92
UniProt ID: Q9NX76

Gene Ontology (top 5):
GO:0005886 - plasma membrane
GO:0015031 - protein transport
GO:0016020 - membrane
GO:0031647 - regulation of protein stability
GO:0031901 - early endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

683351

TNR5
Tumor necrosis factor receptor superfamily member 5

3

2

High-throughput

0.665

High

1451906

PD1L1
Programmed cell death 1 ligand 1

2

1

Small-scale

0.621

High

351847

BY55
CD160 antigen

2

1

High-throughput

0.606

High

1219358

ECM29
Proteasome adapter and scaffold protein ECM29

2

1

High-throughput

0.606

High

829932

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.602

High

1312998

S35F2
Solute carrier family 35 member F2

2

1

High-throughput

0.601

High

870192

GLIP1
Glioma pathogenesis-related protein 1

2

0

High-throughput

0.585

High

794645

RBMX
RNA-binding motif protein, X chromosome

2

0

High-throughput

0.580

High

1150184

TCEA2
Transcription elongation factor A protein 2

2

1

High-throughput

0.553

High

1245852

TMED8
Protein TMED8

2

1

High-throughput

0.553

High

1246214

APOA5
Apolipoprotein A-V

2

5

High-throughput

0.553

High

1322243

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.553

High

1341333

COQ8A
Atypical kinase COQ8A, mitochondrial

2

2

High-throughput

0.553

High

1434760

CIA2A
Cytosolic iron-sulfur assembly component 2A

2

1

High-throughput

0.553

High

1447111

MID51
Mitochondrial dynamics protein MIEF1

2

1

High-throughput

0.553

High

1451904

SPG21
Maspardin

2

3

High-throughput

0.553

High

125058

KCNK1
Potassium channel subfamily K member 1

1

1

High-throughput

0.536

High

141875

ACKR2
Atypical chemokine receptor 2

1

3

High-throughput

0.536

High

166063

FFAR1
Free fatty acid receptor 1

1

7

High-throughput

0.536

High

182807

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

226378

SNG1
Synaptogyrin-1

1

2

High-throughput

0.536

High

349594

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

351979

S1PR4
Sphingosine 1-phosphate receptor 4

1

6

High-throughput

0.536

High

638255

S1PR1
Sphingosine 1-phosphate receptor 1

1

5

High-throughput

0.536

High

689867

CD27
CD27 antigen

1

2

High-throughput

0.536

High

733092

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

4

High-throughput

0.536

High

771253

APJ
Apelin receptor

1

2

High-throughput

0.536

High

820592

GPV
Platelet glycoprotein V

1

2

High-throughput

0.536

High

833882

P2RY2
P2Y purinoceptor 2

1

4

High-throughput

0.536

High

835409

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

4

High-throughput

0.536

High

845153

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

878104

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.536

High

1101683

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.536

High

1291912

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

4

High-throughput

0.536

High

1350152

SPP
Signal peptide peptidase

1

1

High-throughput

0.536

High

1382073

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

1438463

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.536

High

1438768

GPR35
G-protein coupled receptor 35

1

5

High-throughput

0.536

High

1451910

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.536

High

291871

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

749290

CD70
CD70 antigen

1

0

High-throughput

0.513

High

749410

TNFL8
Tumor necrosis factor ligand superfamily member 8

1

0

High-throughput

0.513

High

1086130

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1131944

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

1

0

High-throughput

0.513

High

1159245

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.513

High

1291696

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

1309422

CA210
Type III endosome membrane protein TEMP

1

0

High-throughput

0.513

High

1330752

SIGL1
SIGLEC family-like protein 1

1

0

High-throughput

0.513

High

1351744

GPBAR
G-protein coupled bile acid receptor 1

1

0

High-throughput

0.513

High

1399633

OPALI
Opalin

1

0

High-throughput

0.513

High

1446666

SLAF7
SLAM family member 7

1

0

High-throughput

0.513

High

1449105

GP173
Probable G-protein coupled receptor 173

1

0

High-throughput

0.513

High

1451905

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.513

High

1451909

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.513

High

1446644

AT132
Polyamine-transporting ATPase 13A2

1

2

High-throughput

0.508

High

1028898

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.493

High

1400563

TM237
Transmembrane protein 237

1

0

High-throughput

0.493

High

1258463

CHSS3
Chondroitin sulfate synthase 3

1

1

High-throughput

0.489

High

1291514

RETR3
Reticulophagy regulator 3

1

4

High-throughput

0.489

High

558444

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

212498

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.479

High

850908

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

1

2

High-throughput

0.479

High

1366272

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.479

High

1431467

P2Y12
P2Y purinoceptor 12

1

4

High-throughput

0.479

High

1164090

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.458

High

1438551

LFG4
Protein lifeguard 4

1

0

High-throughput

0.458

High

722644

CTR1
High affinity cationic amino acid transporter 1

1

5

High-throughput

0.445

High

1153348

AAAT
Neutral amino acid transporter B(0)

1

1

High-throughput

0.445

High

1236356

MFSD5
Molybdate-anion transporter

1

1

High-throughput

0.445

High

1316823

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

1

1

Small-scale

0.445

High

1348650

S7A14
Solute carrier family 7 member 14

1

5

High-throughput

0.445

High

1451908

S23A1
Solute carrier family 23 member 1

1

1

High-throughput

0.445

High

1451903

TBA8
Tubulin alpha-8 chain

1

2

High-throughput

0.439

High

551292

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.437

High

1231150

SCAR3
Scavenger receptor class A member 3

1

1

High-throughput

0.437

High

1255814

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

471935

RU2B
U2 small nuclear ribonucleoprotein B''

2

0

High-throughput

0.316

High

1387786

BPIA2
BPI fold-containing family A member 2

2

0

High-throughput

0.316

High

1415511

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.316

High

1240784

PMF1
Polyamine-modulated factor 1

2

0

High-throughput

0.305

High

219383

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.279

Low

1185906

TMM95
Sperm-egg fusion protein TMEM95

1

0

High-throughput

0.279

Low

1451902

CLDN1
Claudin domain-containing protein 1

1

0

High-throughput

0.279

Low

1064039

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

390345

CXCL7
Platelet basic protein

1

0

High-throughput

0.265

Low

964477

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.265

Low

1451907

DNM3B
DNA

1

0

High-throughput

0.265

Low

1451911

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.265

Low

1317008

FAM9B
Protein FAM9B

1

0

High-throughput

0.251

Low

414725

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

808180

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.249

Low

511046

PNM6A
Paraneoplastic antigen-like protein 6A

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025