Protein: JOS2
Josephin-2 (EC 3.4.19.12) (Josephin domain-containing protein 2)

Gene: JOS2, JOSD2
Organism: Homo sapiens
Interactions: 37
UniProt ID: Q8TAC2

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0016579 - protein deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508310

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

5

Small-scale

0.845

High

230076

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

6

4

High-throughput

0.733

High

1179768

TYSD1
Peroxisomal leader peptide-processing protease

4

1

High-throughput

0.694

High

1346716

SAHH3
Adenosylhomocysteinase 3

4

4

High-throughput

0.694

High

515717

TPC2B
Trafficking protein particle complex subunit 2B

5

1

High-throughput

0.641

High

999387

HBB
Hemoglobin subunit beta

3

0

High-throughput

0.638

High

1346717

SPRR3
Small proline-rich protein 3

3

0

High-throughput

0.629

High

862314

YAP1
Transcriptional coactivator YAP1

2

7

Small-scale

0.624

High

764896

CTNB1
Catenin beta-1

2

2

Small-scale

0.584

High

885173

TTPA
Alpha-tocopherol transfer protein

2

0

High-throughput

0.580

High

909454

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

2

2

High-throughput

0.574

High

515645

TPC2A
Trafficking protein particle complex subunit 2

1

1

High-throughput

0.515

High

1346719

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.501

High

209621

SERA
D-3-phosphoglycerate dehydrogenase

1

1

Small-scale

0.479

High

350078

SNAI1
Zinc finger protein SNAI1

1

1

Small-scale

0.479

High

402643

ALDOA
Fructose-bisphosphate aldolase A

1

1

Small-scale

0.479

High

1337297

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

2

Small-scale

0.479

High

1346721

ZHX2
Zinc fingers and homeoboxes protein 2

1

2

Small-scale

0.479

High

467942

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

0

Small-scale

0.458

High

903206

SMCA2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2

1

1

High-throughput

0.437

High

1278040

MAVS
Mitochondrial antiviral-signaling protein

1

2

Small-scale

0.437

High

1311907

MCEM1
Mast cell-expressed membrane protein 1

3

0

High-throughput

0.345

High

1346718

COMD3
COMM domain-containing protein 3

2

0

High-throughput

0.328

High

1194614

DUS28
Dual specificity phosphatase 28

2

0

High-throughput

0.318

High

325569

YIF1A
Protein YIF1A

2

0

High-throughput

0.316

High

469516

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

640604

MK
Midkine

2

0

High-throughput

0.316

High

1341268

COQ8A
Atypical kinase COQ8A, mitochondrial

2

0

High-throughput

0.316

High

1346714

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

2

0

High-throughput

0.316

High

1346720

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

1346713

TOMT
Transmembrane O-methyltransferase

2

0

High-throughput

0.313

High

60849

CQ102
Uncharacterized protein TMEM132E-DT

1

0

High-throughput

0.279

Low

1179265

CB068
UPF0561 protein C2orf68

1

0

High-throughput

0.279

Low

1331456

ZFP41
Zinc finger protein 41 homolog

1

0

High-throughput

0.279

Low

572749

PA2GA
Phospholipase A2, membrane associated

1

0

Small-scale

0.261

Low

1160423

TAZ
Tafazzin

1

0

Small-scale

0.249

Low

1346715

LRC51
Leucine-rich repeat-containing protein 51

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025