Protein: SYPH
Synaptophysin (Major synaptic vesicle protein p38)

Gene: SYPH, SYP
Organism: Homo sapiens
Interactions: 152
UniProt ID: P08247

Gene Ontology (top 5):
GO:0006897 - endocytosis
GO:0008021 - synaptic vesicle
GO:0010807 - regulation of synaptic vesicle priming
GO:0015485 - cholesterol binding
GO:0016188 - synaptic vesicle maturation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

469566

NUFP1
FMR1-interacting protein NUFIP1

3

0

High-throughput

0.638

High

243881

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

2

1

High-throughput

0.628

High

469456

GDC
Solute carrier family 25 member 16

3

2

High-throughput

0.604

High

469551

S38AA
Solute carrier family 38 member 10

3

1

High-throughput

0.604

High

270614

ATP9A
Probable phospholipid-transporting ATPase IIA

2

0

High-throughput

0.602

High

469468

HD
Huntingtin

2

1

High-throughput

0.588

High

469527

STAR4
StAR-related lipid transfer protein 4

2

0

High-throughput

0.580

High

469478

S20A2
Sodium-dependent phosphate transporter 2

2

1

High-throughput

0.574

High

469538

SCMC3
Mitochondrial adenyl nucleotide antiporter SLC25A23

2

1

High-throughput

0.574

High

469540

SFXN3
Sideroflexin-3

2

2

High-throughput

0.574

High

469459

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

2

1

High-throughput

0.553

High

469473

ARFP2
Arfaptin-2

2

1

High-throughput

0.553

High

469512

RBFA
Putative ribosome-binding factor A, mitochondrial

2

1

High-throughput

0.553

High

469526

MID49
Mitochondrial dynamics protein MID49

2

1

High-throughput

0.553

High

469542

LNP
Endoplasmic reticulum junction formation protein lunapark

2

1

High-throughput

0.553

High

469555

MID51
Mitochondrial dynamics protein MIEF1

2

1

High-throughput

0.553

High

469520

S20A1
Sodium-dependent phosphate transporter 1

2

1

High-throughput

0.549

High

469474

VAMP2
Vesicle-associated membrane protein 2

1

6

High-throughput

0.536

High

469523

LPAR1
Lysophosphatidic acid receptor 1

1

1

High-throughput

0.536

High

105155

APRIO
Alternative prion protein

2

2

Small-scale

0.533

High

225765

AP1G1
AP-1 complex subunit gamma-1

1

0

Small-scale

0.529

High

421336

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

271654

HIP1R
Huntingtin-interacting protein 1-related protein

1

0

High-throughput

0.513

High

469472

GPM6A
Neuronal membrane glycoprotein M6-a

1

0

High-throughput

0.513

High

469479

CLN3
Battenin

1

0

High-throughput

0.513

High

469455

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.493

High

230742

EXTL3
Exostosin-like 3

1

1

High-throughput

0.489

High

469487

EXT1
Exostosin-1

1

1

High-throughput

0.489

High

469501

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.489

High

469502

S27A1
Long-chain fatty acid transport protein 1

1

1

High-throughput

0.489

High

469507

PCAT2
Lysophosphatidylcholine acyltransferase 2

1

1

High-throughput

0.489

High

469508

DSG4
Desmoglein-4

1

1

High-throughput

0.489

High

469509

GPAT4
Glycerol-3-phosphate acyltransferase 4

1

1

High-throughput

0.489

High

469534

SFXN2
Sideroflexin-2

1

2

High-throughput

0.489

High

469552

TPC
Mitochondrial thiamine pyrophosphate carrier

1

2

High-throughput

0.489

High

469562

MTCH1
Mitochondrial carrier homolog 1

1

3

High-throughput

0.489

High

469577

ORNT1
Mitochondrial ornithine transporter 1

1

4

High-throughput

0.489

High

469548

DNJC5
DnaJ homolog subfamily C member 5

1

0

High-throughput

0.480

High

46758

A0A384ME17
Elongation factor Tu

1

1

High-throughput

0.470

High

469482

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.470

High

469524

Q96AL5
PBX3 protein

1

3

High-throughput

0.470

High

469488

STX1A
Syntaxin-1A

1

0

Small-scale

0.458

High

469569

RAB26
Ras-related protein Rab-26

1

0

Small-scale

0.458

High

469510

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.457

High

469554

AT132
Polyamine-transporting ATPase 13A2

1

2

High-throughput

0.445

High

469466

PBX3
Pre-B-cell leukemia transcription factor 3

1

3

High-throughput

0.439

High

469470

EFTU
Elongation factor Tu, mitochondrial

1

1

High-throughput

0.439

High

250198

VINEX
Vinexin

1

1

Small-scale

0.437

High

469543

SRCN1
SRC kinase signaling inhibitor 1

1

1

Small-scale

0.437

High

155228

AGRB1
Adhesion G protein-coupled receptor B1

1

0

High-throughput

0.426

High

339036

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.426

High

469454

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

469457

CADH2
Cadherin-2

1

0

High-throughput

0.426

High

469476

ATP7A
Copper-transporting ATPase 1

1

0

High-throughput

0.426

High

469571

NAC2
Sodium/calcium exchanger 2

1

0

High-throughput

0.426

High

268973

ABCB7
Iron-sulfur clusters transporter ABCB7, mitochondrial

1

1

High-throughput

0.407

High

469504

LRRN1
Leucine-rich repeat neuronal protein 1

1

1

High-throughput

0.407

High

469514

S2529
Mitochondrial basic amino acids transporter

1

2

High-throughput

0.407

High

469518

SFXN5
Sideroflexin-5

1

2

High-throughput

0.407

High

469489

DGUOK
Deoxyguanosine kinase, mitochondrial

3

0

High-throughput

0.347

High

126969

APBB1
Amyloid beta precursor protein binding family B member 1

3

0

High-throughput

0.345

High

469574

SHLB1
Endophilin-B1

3

0

High-throughput

0.344

High

469461

GLPK
Glycerol kinase

2

0

High-throughput

0.328

High

469475

PTPS
6-pyruvoyl tetrahydrobiopterin synthase

2

0

High-throughput

0.328

High

469477

RN5A
2-5A-dependent ribonuclease

2

0

High-throughput

0.328

High

469496

TMTC4
Protein O-mannosyl-transferase TMTC4

2

0

High-throughput

0.328

High

469511

T183A
Transmembrane protein 183A

2

0

High-throughput

0.328

High

469515

TM87A
Transmembrane protein 87A

2

0

High-throughput

0.328

High

469517

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

2

0

High-throughput

0.328

High

469541

SGPP1
Sphingosine-1-phosphate phosphatase 1

2

0

High-throughput

0.328

High

469546

ARV1
Protein ARV1

2

0

High-throughput

0.328

High

469553

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

2

0

High-throughput

0.328

High

238781

SSX5
Protein SSX5

2

0

High-throughput

0.316

High

253042

PLIN3
Perilipin-3

2

0

High-throughput

0.316

High

271012

PTCD1
Pentatricopeptide repeat-containing protein 1, mitochondrial

2

0

High-throughput

0.316

High

273155

CAND2
Cullin-associated NEDD8-dissociated protein 2

2

0

High-throughput

0.316

High

334369

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

351812

BY55
CD160 antigen

2

0

High-throughput

0.316

High

469465

GDNF
Glial cell line-derived neurotrophic factor

2

0

High-throughput

0.316

High

469469

PTN9
Tyrosine-protein phosphatase non-receptor type 9

2

0

High-throughput

0.316

High

469481

SNX1
Sorting nexin-1

2

0

High-throughput

0.316

High

469499

MRM1
rRNA methyltransferase 1, mitochondrial

2

0

High-throughput

0.316

High

469516

JOS2
Josephin-2

2

0

High-throughput

0.316

High

469521

THAP4
Peroxynitrite isomerase THAP4

2

0

High-throughput

0.316

High

469528

RRFM
Ribosome-recycling factor, mitochondrial

2

0

High-throughput

0.316

High

469529

MTEF3
Transcription termination factor 3, mitochondrial

2

0

High-throughput

0.316

High

469535

WDFY2
WD repeat and FYVE domain-containing protein 2

2

0

High-throughput

0.316

High

469536

PNKP
Bifunctional polynucleotide phosphatase/kinase

2

0

High-throughput

0.316

High

469545

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.316

High

469556

DBLOH
Diablo IAP-binding mitochondrial protein

2

0

High-throughput

0.316

High

469561

SPG21
Maspardin

2

0

High-throughput

0.316

High

469565

HSFX1
Heat shock transcription factor, X-linked

2

0

High-throughput

0.316

High

469567

PITC1
Cytoplasmic phosphatidylinositol transfer protein 1

2

0

High-throughput

0.316

High

469568

NDRG4
Protein NDRG4

2

0

High-throughput

0.316

High

469575

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

2

0

High-throughput

0.316

High

316475

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

2

0

High-throughput

0.313

High

469458

AOFB
Amine oxidase [flavin-containing] B

2

0

High-throughput

0.313

High

469503

DHR13
Dehydrogenase/reductase SDR family member 13

2

0

High-throughput

0.313

High

127600

HYAS3
Hyaluronan synthase 3

1

0

High-throughput

0.279

Low

209734

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.279

Low

225353

ERD23
ER lumen protein-retaining receptor 3

1

0

High-throughput

0.279

Low

302013

NCTR1
Natural cytotoxicity triggering receptor 1

1

0

High-throughput

0.279

Low

468971

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

469463

S10A3
Protein S100-A3

1

0

High-throughput

0.279

Low

469464

FDFT
Squalene synthase

1

0

High-throughput

0.279

Low

469467

ETV3
ETS translocation variant 3

1

0

High-throughput

0.279

Low

469483

LBR
Delta(14)-sterol reductase LBR

1

0

High-throughput

0.279

Low

469485

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.279

Low

469486

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.279

Low

469490

ALG11
GDP-Man:Man(3)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase

1

0

High-throughput

0.279

Low

469493

MTX3
Metaxin-3

1

0

High-throughput

0.279

Low

469494

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.279

Low

469497

TM164
Transmembrane protein 164

1

0

High-throughput

0.279

Low

469498

ECM29
Proteasome adapter and scaffold protein ECM29

1

0

High-throughput

0.279

Low

469500

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

469513

MACOI
Macoilin

1

0

High-throughput

0.279

Low

469519

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

469522

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.279

Low

469525

TM186
Transmembrane protein 186

1

0

High-throughput

0.279

Low

469530

BSCL2
Seipin

1

0

High-throughput

0.279

Low

469532

ARL5B
ADP-ribosylation factor-like protein 5B

1

0

High-throughput

0.279

Low

469533

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

1

0

High-throughput

0.279

Low

469539

PTSS2
Phosphatidylserine synthase 2

1

0

High-throughput

0.279

Low

469544

TSYL1
Testis-specific Y-encoded-like protein 1

1

0

High-throughput

0.279

Low

469547

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.279

Low

469549

S61A2
Protein transport protein Sec61 subunit alpha isoform 2

1

0

High-throughput

0.279

Low

469558

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.279

Low

469563

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.279

Low

469564

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.279

Low

469570

TMCO1
Calcium load-activated calcium channel

1

0

High-throughput

0.279

Low

469573

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

0

High-throughput

0.279

Low

469576

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low

469550

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

469480

GAB1
GRB2-associated-binding protein 1

1

0

Small-scale

0.261

Low

124204

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

469491

BOREA
Borealin

1

0

High-throughput

0.249

Low

469559

KTU
Protein kintoun

1

0

High-throughput

0.249

Low

49428

TM223
Transmembrane protein 223

1

0

High-throughput

0.232

Low

469453

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

469460

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.232

Low

469462

MRP1
Multidrug resistance-associated protein 1

1

0

High-throughput

0.232

Low

469471

S26A2
Sulfate transporter

1

0

High-throughput

0.232

Low

469484

UBE3C
Ubiquitin-protein ligase E3C

1

0

High-throughput

0.232

Low

469492

WDR81
WD repeat-containing protein 81

1

0

High-throughput

0.232

Low

469495

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.232

Low

469505

DUSTY
Dual serine/threonine and tyrosine protein kinase

1

0

High-throughput

0.232

Low

469506

HACD2
Very-long-chain

1

0

High-throughput

0.232

Low

469531

RUSF1
RUS family member 1

1

0

High-throughput

0.232

Low

469537

CYBC1
Cytochrome b-245 chaperone 1

1

0

High-throughput

0.232

Low

469557

PLCD
1-acyl-sn-glycerol-3-phosphate acyltransferase delta

1

0

High-throughput

0.232

Low

469560

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.232

Low

469572

MGT4B
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025