Protein: MED21
Mediator of RNA polymerase II transcription subunit 21 (Mediator complex subunit 21) (RNA polymerase II holoenzyme component SRB7) (RNAPII complex component SRB7) (hSrb7)

Gene: MED21
Organism: Homo sapiens
Interactions: 152
UniProt ID: Q13503

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0001824 - blastocyst development
GO:0003712 - transcription coregulator activity
GO:0003713 - transcription coactivator activity
GO:0003899 - DNA-directed 5'-3' RNA polymerase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1037090

MED10
Mediator of RNA polymerase II transcription subunit 10

7

1

Small-scale

0.967

High

1037101

MED4
Mediator of RNA polymerase II transcription subunit 4

6

1

Small-scale

0.955

High

206619

MED7
Mediator of RNA polymerase II transcription subunit 7

6

3

Small-scale

0.950

High

225374

MED14
Mediator of RNA polymerase II transcription subunit 14

5

2

Small-scale

0.930

High

313422

MED26
Mediator of RNA polymerase II transcription subunit 26

7

0

Small-scale

0.922

High

1037105

MED9
Mediator of RNA polymerase II transcription subunit 9

8

0

Small-scale

0.921

High

826268

CDK8
Cyclin-dependent kinase 8

14

3

Small-scale

0.762

High

1037081

MED12
Mediator of RNA polymerase II transcription subunit 12

6

2

High-throughput

0.738

High

1037112

MED13
Mediator of RNA polymerase II transcription subunit 13

5

1

High-throughput

0.723

High

48659

MED19
Mediator of RNA polymerase II transcription subunit 19

8

0

Small-scale

0.721

High

270500

MED6
Mediator of RNA polymerase II transcription subunit 6

5

1

Small-scale

0.720

High

624429

CCNC
Cyclin-C

5

1

High-throughput

0.718

High

1037099

MED28
Mediator of RNA polymerase II transcription subunit 28

7

0

Small-scale

0.717

High

1037094

CDK19
Cyclin-dependent kinase 19

5

3

High-throughput

0.716

High

1037107

MED29
Mediator of RNA polymerase II transcription subunit 29

6

0

Small-scale

0.708

High

1037085

MED30
Mediator of RNA polymerase II transcription subunit 30

6

0

Small-scale

0.706

High

1037091

MED18
Mediator of RNA polymerase II transcription subunit 18

6

0

Small-scale

0.706

High

1037053

MED1
Mediator of RNA polymerase II transcription subunit 1

6

0

Small-scale

0.705

High

1037066

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

4

1

High-throughput

0.704

High

624888

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

0

Small-scale

0.702

High

1037100

MED20
Mediator of RNA polymerase II transcription subunit 20

5

0

High-throughput

0.694

High

1037114

MED23
Mediator of RNA polymerase II transcription subunit 23

5

0

High-throughput

0.691

High

180543

MAGB4
Melanoma-associated antigen B4

3

2

High-throughput

0.675

High

1037069

MD12L
Mediator of RNA polymerase II transcription subunit 12-like protein

3

1

High-throughput

0.675

High

1037088

MED15
Mediator of RNA polymerase II transcription subunit 15

3

2

High-throughput

0.675

High

265321

MED24
Mediator of RNA polymerase II transcription subunit 24

4

0

High-throughput

0.674

High

1037051

MED22
Mediator of RNA polymerase II transcription subunit 22

4

0

High-throughput

0.674

High

1037061

MED27
Mediator of RNA polymerase II transcription subunit 27

4

0

High-throughput

0.674

High

1037083

MED8
Mediator of RNA polymerase II transcription subunit 8

4

0

High-throughput

0.674

High

1037104

MED17
Mediator of RNA polymerase II transcription subunit 17

4

0

High-throughput

0.674

High

1037108

MED11
Mediator of RNA polymerase II transcription subunit 11

4

0

High-throughput

0.674

High

1037116

MED16
Mediator of RNA polymerase II transcription subunit 16

4

0

High-throughput

0.674

High

1037117

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

High-throughput

0.674

High

1037049

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

High-throughput

0.663

High

181415

RPB4
DNA-directed RNA polymerase II subunit RPB4

3

0

High-throughput

0.646

High

854417

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

3

0

High-throughput

0.638

High

1037067

MED25
Mediator of RNA polymerase II transcription subunit 25

3

0

High-throughput

0.638

High

256250

BRE1B
E3 ubiquitin-protein ligase BRE1B

2

1

High-throughput

0.628

High

412181

FYN
Tyrosine-protein kinase Fyn

2

2

High-throughput

0.628

High

433347

YES
Tyrosine-protein kinase Yes

2

2

High-throughput

0.628

High

522966

SRC
Proto-oncogene tyrosine-protein kinase Src

2

2

High-throughput

0.628

High

985953

PTN11
Tyrosine-protein phosphatase non-receptor type 11

2

1

High-throughput

0.628

High

1037058

BRE1A
E3 ubiquitin-protein ligase BRE1A

2

1

High-throughput

0.628

High

50858

SRCRL
Soluble scavenger receptor cysteine-rich domain-containing protein SSC5D

3

1

High-throughput

0.616

High

500416

THA
Thyroid hormone receptor alpha

2

3

Small-scale

0.606

High

1037064

TRI72
Tripartite motif-containing protein 72

2

1

High-throughput

0.606

High

177679

BIRC5
Baculoviral IAP repeat-containing protein 5

2

0

High-throughput

0.602

High

274827

PALM
Paralemmin-1

2

0

High-throughput

0.602

High

583700

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.602

High

1037063

FXL19
F-box/LRR-repeat protein 19

2

0

High-throughput

0.602

High

1037073

SCPDL
Saccharopine dehydrogenase-like oxidoreductase

2

0

High-throughput

0.602

High

1037089

KIF2C
Kinesin-like protein KIF2C

2

0

High-throughput

0.602

High

1037119

KC1G3
Casein kinase I isoform gamma-3

2

0

High-throughput

0.602

High

583473

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

High-throughput

0.585

High

676876

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

722601

T2FA
General transcription factor IIF subunit 1

2

0

Small-scale

0.585

High

738843

RPB9
DNA-directed RNA polymerase II subunit RPB9

2

0

High-throughput

0.585

High

864944

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

913895

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

High-throughput

0.585

High

959926

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.585

High

1037070

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

2

0

High-throughput

0.585

High

244395

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

580426

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

2

1

High-throughput

0.574

High

1037054

VAMP3
Vesicle-associated membrane protein 3

2

1

High-throughput

0.574

High

1037092

VAMP8
Vesicle-associated membrane protein 8

2

1

High-throughput

0.574

High

1037082

FBXW7
F-box/WD repeat-containing protein 7

2

0

Small-scale

0.559

High

1037071

ZN655
Zinc finger protein 655

1

0

High-throughput

0.549

High

928898

SKP1
S-phase kinase-associated protein 1

1

0

Small-scale

0.543

High

536813

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.541

High

749465

BRCA1
Breast cancer type 1 susceptibility protein

1

1

Small-scale

0.536

High

791537

HD
Huntingtin

1

0

High-throughput

0.518

High

1037052

TRBP2
RISC-loading complex subunit TARBP2

1

0

High-throughput

0.518

High

1037072

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

1037098

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.518

High

349295

RASH
GTPase HRas

1

0

High-throughput

0.513

High

586730

CSK22
Casein kinase II subunit alpha'

1

0

High-throughput

0.513

High

664015

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.513

High

1037065

ACD11
Acyl-CoA dehydrogenase family member 11

1

0

High-throughput

0.513

High

1037074

CCNY
Cyclin-Y

1

0

High-throughput

0.513

High

1037078

TF2H4
General transcription factor IIH subunit 4

1

0

Small-scale

0.513

High

1037097

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.513

High

369547

ESR1
Estrogen receptor

1

3

Small-scale

0.501

High

500481

THB
Thyroid hormone receptor beta

1

3

Small-scale

0.501

High

782539

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

1037077

ESR2
Estrogen receptor beta

1

3

Small-scale

0.501

High

554446

GATA1
Erythroid transcription factor

1

1

Small-scale

0.500

High

157898

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

837609

GNAQ
Guanine nucleotide-binding protein G(q) subunit alpha

1

1

High-throughput

0.489

High

795863

MAGA6
Melanoma-associated antigen 6

1

2

High-throughput

0.481

High

386680

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

487408

ANDR
Androgen receptor

1

3

High-throughput

0.479

High

509945

VDR
Vitamin D3 receptor

1

3

Small-scale

0.479

High

569693

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

738964

SRBP1
Sterol regulatory element-binding protein 1

1

1

Small-scale

0.479

High

1037057

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

1

High-throughput

0.479

High

1037079

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

1037080

KAT2B
Histone acetyltransferase KAT2B

1

3

Small-scale

0.479

High

1037086

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

2

High-throughput

0.479

High

1034820

LSAMP
Limbic system-associated membrane protein

1

1

High-throughput

0.470

High

154798

TCRG1
Transcription elongation regulator 1

1

0

Small-scale

0.458

High

179626

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

270195

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.458

High

295530

RECQ5
ATP-dependent DNA helicase Q5

1

0

High-throughput

0.458

High

304614

SCAF4
SR-related and CTD-associated factor 4

1

0

High-throughput

0.458

High

841190

CDK7
Cyclin-dependent kinase 7

1

0

Small-scale

0.458

High

854298

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

897513

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

921112

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

1017112

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.458

High

1037055

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

0

High-throughput

0.458

High

1037096

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1037109

PRGC1
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha

1

0

Small-scale

0.458

High

1037110

UXT
Protein UXT

1

0

High-throughput

0.458

High

73027

B4DUB1
cDNA FLJ50029, highly similar to Cell division cycle 2-like protein kinase 6

1

3

High-throughput

0.445

High

91297

E5RFK5
Cyclin-C

1

1

High-throughput

0.445

High

1037059

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

831296

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

150566

ABLM1
Actin-binding LIM protein 1

2

0

High-throughput

0.328

High

276441

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.328

High

277563

DHRS3
Short-chain dehydrogenase/reductase 3

2

0

High-throughput

0.328

High

311075

MPZL1
Myelin protein zero-like protein 1

2

0

High-throughput

0.328

High

314985

SGPL1
Sphingosine-1-phosphate lyase 1

2

0

High-throughput

0.328

High

570257

NEUM
Neuromodulin

2

0

High-throughput

0.328

High

617109

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

2

0

High-throughput

0.328

High

856602

EFNA5
Ephrin-A5

2

0

High-throughput

0.328

High

990436

CKAP4
Cytoskeleton-associated protein 4

2

0

High-throughput

0.328

High

1018290

CNTN1
Contactin-1

2

0

High-throughput

0.328

High

1037050

I5P1
Inositol polyphosphate-5-phosphatase A

2

0

High-throughput

0.328

High

1037068

EEPD1
Endonuclease/exonuclease/phosphatase family domain-containing protein 1

2

0

High-throughput

0.328

High

1037087

SPAG5
Sperm-associated antigen 5

2

0

High-throughput

0.328

High

1037095

ULBP2
UL16-binding protein 2

2

0

High-throughput

0.328

High

1037111

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

2

0

High-throughput

0.328

High

1037115

STX8
Syntaxin-8

2

0

High-throughput

0.328

High

159989

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

0

High-throughput

0.316

High

1037084

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1037102

MID51
Mitochondrial dynamics protein MIEF1

2

0

High-throughput

0.316

High

1037060

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

2

0

High-throughput

0.305

High

1037113

BL1S6
Biogenesis of lysosome-related organelles complex 1 subunit 6

1

0

High-throughput

0.299

High

473903

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.288

High

361572

APOA2
Apolipoprotein A-II

1

0

High-throughput

0.279

Low

361661

APOC2
Apolipoprotein C-II

1

0

High-throughput

0.279

Low

740660

HPCL1
Hippocalcin-like protein 1

1

0

High-throughput

0.279

Low

1037056

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.279

Low

1037062

ERIC5
Glutamate-rich protein 5

1

0

High-throughput

0.279

Low

1037075

OCC1
Overexpressed in colon carcinoma 1 protein

1

0

High-throughput

0.279

Low

1037076

ASM3B
Acid sphingomyelinase-like phosphodiesterase 3b

1

0

High-throughput

0.279

Low

1037106

PHAG1
Phosphoprotein associated with glycosphingolipid-enriched microdomains 1

1

0

High-throughput

0.279

Low

1037118

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.279

Low

1037093

NUP58
Nucleoporin p58/p45

1

0

High-throughput

0.268

Low

855793

VAV2
Guanine nucleotide exchange factor VAV2

1

0

High-throughput

0.265

Low

1037103

PDRG1
p53 and DNA damage-regulated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024