Protein: NUCB2
Nucleobindin-2 (DNA-binding protein NEFA) (Epididymis secretory protein Li 109) (Gastric cancer antigen Zg4) (Prepronesfatin) [Cleaved into: Nesfatin-1]

Gene: NUCB2
Organism: Homo sapiens
Interactions: 161
UniProt ID: P80303

Gene Ontology (top 5):
GO:0001965 - G-protein alpha-subunit binding
GO:0003677 - DNA binding
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005509 - calcium ion binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

877769

TNNI2
Troponin I, fast skeletal muscle

2

0

High-throughput

0.770

High

603637

JUNB
Transcription factor JunB

3

1

High-throughput

0.662

High

1009825

NUCB1
Nucleobindin-1

4

0

High-throughput

0.657

High

1009903

TREM2
Triggering receptor expressed on myeloid cells 2

1

0

High-throughput

0.656

High

1009916

COL10
Collectin-10

3

0

High-throughput

0.638

High

229691

CALU
Calumenin

1

2

High-throughput

0.618

High

566628

PDIA4
Protein disulfide-isomerase A4

1

3

High-throughput

0.618

High

820621

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.618

High

1009849

SYNE3
Nesprin-3

1

1

High-throughput

0.618

High

1009852

DJC10
DnaJ homolog subfamily C member 10

1

5

High-throughput

0.618

High

1009915

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

1

Small-scale

0.618

High

1009836

RCN1
Reticulocalbin-1

1

2

High-throughput

0.575

High

1009870

SCYL1
N-terminal kinase-like protein

1

1

High-throughput

0.575

High

1009878

ERP44
Endoplasmic reticulum resident protein 44

1

4

High-throughput

0.575

High

1009900

PSD3
PH and SEC7 domain-containing protein 3

1

1

High-throughput

0.575

High

1009875

NECD
Necdin

1

1

Small-scale

0.573

High

534930

BIP
Endoplasmic reticulum chaperone BiP

2

1

High-throughput

0.571

High

1009904

VAPA
Vesicle-associated membrane protein-associated protein A

2

1

High-throughput

0.571

High

566960

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.546

High

876823

KC1A
Casein kinase I isoform alpha

1

0

High-throughput

0.546

High

1009861

MCFD2
Multiple coagulation factor deficiency protein 2

1

0

High-throughput

0.546

High

429717

JUN
Transcription factor Jun

1

3

High-throughput

0.536

High

921330

CEBPG
CCAAT/enhancer-binding protein gamma

1

3

High-throughput

0.536

High

921864

COPA
Coatomer subunit alpha

1

1

High-throughput

0.536

High

1009856

FNDC5
Fibronectin type III domain-containing protein 5

1

2

High-throughput

0.536

High

1009889

MANS1
MANSC domain-containing protein 1

1

1

High-throughput

0.536

High

1009909

PA2GD
Group IID secretory phospholipase A2

1

1

High-throughput

0.536

High

1009910

ANGP4
Angiopoietin-4

1

1

High-throughput

0.536

High

1009871

CALR3
Calreticulin-3

2

3

High-throughput

0.533

High

460802

CATB
Cathepsin B

1

1

High-throughput

0.515

High

692924

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

1009888

TMX1
Thioredoxin-related transmembrane protein 1

1

5

High-throughput

0.514

High

158178

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.513

High

1009830

CUL2
Cullin-2

1

0

High-throughput

0.513

High

1009865

YIPF5
Protein YIPF5

1

0

High-throughput

0.513

High

390534

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.493

High

680691

CATS
Cathepsin S

1

0

High-throughput

0.493

High

1009886

CSTL1
Cystatin-like 1

1

1

High-throughput

0.489

High

1009902

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.484

High

318974

MICA2
[F-actin]-monooxygenase MICAL2

1

0

High-throughput

0.481

High

172696

XPO1
Exportin-1

1

1

High-throughput

0.481

High

475947

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

7

High-throughput

0.481

High

989715

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

7

High-throughput

0.481

High

1009842

AR13B
ADP-ribosylation factor-like protein 13B

1

1

High-throughput

0.481

High

218053

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

606616

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

720185

UFO
Tyrosine-protein kinase receptor UFO

1

4

High-throughput

0.479

High

951097

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

1009828

DNJC3
DnaJ homolog subfamily C member 3

1

3

High-throughput

0.479

High

1009840

TECT1
Tectonic-1

1

1

High-throughput

0.479

High

1009844

EPHAA
Ephrin type-A receptor 10

1

2

High-throughput

0.479

High

1009867

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.479

High

1009872

SNX27
Sorting nexin-27

1

1

High-throughput

0.479

High

1009896

T106B
Transmembrane protein 106B

1

1

High-throughput

0.479

High

1009899

DJB12
DnaJ homolog subfamily B member 12

1

3

High-throughput

0.479

High

1009906

DNJB9
DnaJ homolog subfamily B member 9

1

3

High-throughput

0.479

High

1009908

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

194687

FFAR2
Free fatty acid receptor 2

1

0

High-throughput

0.460

High

722438

CTR1
High affinity cationic amino acid transporter 1

1

0

High-throughput

0.460

High

1009826

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.460

High

463939

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

0

High-throughput

0.458

High

798985

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

867040

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

876669

HSP13
Heat shock 70 kDa protein 13

1

0

High-throughput

0.458

High

1009847

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1009864

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1009907

DJB11
DnaJ homolog subfamily B member 11

1

0

High-throughput

0.458

High

48599

ESYT2
Extended synaptotagmin-2

1

1

High-throughput

0.445

High

104332

F5H6I7
Atlastin GTPase 3

1

2

High-throughput

0.445

High

275507

RTN2
Reticulon-2

1

2

High-throughput

0.445

High

328899

RTN3
Reticulon-3

1

2

High-throughput

0.445

High

332967

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

High-throughput

0.445

High

552938

PIP
Prolactin-inducible protein

1

1

High-throughput

0.445

High

697842

CALR
Calreticulin

1

3

High-throughput

0.445

High

698580

CALX
Calnexin

1

3

High-throughput

0.445

High

773478

COPB2
Coatomer subunit beta'

1

1

High-throughput

0.445

High

840039

CASP3
Caspase-3

1

5

Small-scale

0.445

High

888849

TMEDA
Transmembrane emp24 domain-containing protein 10

1

2

High-throughput

0.445

High

936902

CASP7
Caspase-7

1

5

Small-scale

0.445

High

936980

CASP6
Caspase-6

1

5

Small-scale

0.445

High

1009832

CASP8
Caspase-8

1

5

Small-scale

0.445

High

1009837

TMED2
Transmembrane emp24 domain-containing protein 2

1

2

High-throughput

0.445

High

1009843

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

2

High-throughput

0.445

High

1009853

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

1

High-throughput

0.445

High

1009857

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.445

High

1009860

ATLA2
Atlastin-2

1

2

High-throughput

0.445

High

1009863

ATLA1
Atlastin-1

1

2

High-throughput

0.445

High

1009879

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.445

High

1009882

S12A9
Solute carrier family 12 member 9

1

1

High-throughput

0.445

High

1009891

RTN4
Reticulon-4

1

2

High-throughput

0.445

High

1009905

COPG2
Coatomer subunit gamma-2

1

1

High-throughput

0.445

High

1009912

TMED5
Transmembrane emp24 domain-containing protein 5

1

2

High-throughput

0.445

High

1009914

COPG1
Coatomer subunit gamma-1

1

1

High-throughput

0.445

High

1009846

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1009850

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

60324

NBAS
NBAS subunit of NRZ tethering complex

1

0

High-throughput

0.426

High

1009859

VP37A
Vacuolar protein sorting-associated protein 37A

1

0

High-throughput

0.426

High

1009862

SCFD1
Sec1 family domain-containing protein 1

1

0

High-throughput

0.426

High

1009866

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.426

High

1009868

ASTRA
Protein Aster-A

1

0

High-throughput

0.426

High

211774

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.426

High

213592

VIP2
Inositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2

1

0

High-throughput

0.426

High

215545

EMC8
ER membrane protein complex subunit 8

1

0

High-throughput

0.426

High

283235

ERLN1
Erlin-1

1

0

High-throughput

0.426

High

296484

STAM2
Signal transducing adapter molecule 2

1

0

High-throughput

0.426

High

359969

NB5R3
NADH-cytochrome b5 reductase 3

1

0

High-throughput

0.426

High

462352

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

0

High-throughput

0.426

High

598721

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

873203

COPD
Coatomer subunit delta

1

0

High-throughput

0.426

High

883085

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

1

0

High-throughput

0.426

High

903674

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.426

High

903877

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.426

High

921639

COPB
Coatomer subunit beta

1

0

High-throughput

0.426

High

963989

COPZ1
Coatomer subunit zeta-1

1

0

High-throughput

0.426

High

986983

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

1009823

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

1009824

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.426

High

1009827

PRDX4
Peroxiredoxin-4

1

0

High-throughput

0.426

High

1009831

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.426

High

1009833

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.426

High

1009834

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

1

0

High-throughput

0.426

High

1009835

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

High-throughput

0.426

High

1009838

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.426

High

1009839

NSDHL
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating

1

0

High-throughput

0.426

High

1009848

LCLT1
Lysocardiolipin acyltransferase 1

1

0

High-throughput

0.426

High

1009851

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.426

High

1009854

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

1009873

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1009880

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.426

High

1009881

OSB11
Oxysterol-binding protein-related protein 11

1

0

High-throughput

0.426

High

1009883

WDR11
WD repeat-containing protein 11

1

0

High-throughput

0.426

High

1009884

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.426

High

1009885

RGAP1
Rac GTPase-activating protein 1

1

0

High-throughput

0.426

High

1009887

RBGPR
Rab3 GTPase-activating protein non-catalytic subunit

1

0

High-throughput

0.426

High

1009893

ITM2C
Integral membrane protein 2C

1

0

High-throughput

0.426

High

1009894

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.426

High

1009895

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

1009897

TM38B
Trimeric intracellular cation channel type B

1

0

High-throughput

0.426

High

1009901

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.426

High

1009913

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.426

High

1007664

RAE1L
mRNA export factor RAE1

1

1

High-throughput

0.407

High

1009841

LETM2
LETM1 domain-containing protein LETM2, mitochondrial

1

1

High-throughput

0.407

High

1009845

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.407

High

1009877

PXL2A
Peroxiredoxin-like 2A

1

1

High-throughput

0.407

High

1009892

HINT3
Adenosine 5'-monophosphoramidase HINT3

1

1

High-throughput

0.407

High

1009911

DHRS7
Dehydrogenase/reductase SDR family member 7

1

1

High-throughput

0.407

High

948125

Z280A
Zinc finger protein 280A

2

0

High-throughput

0.324

High

665250

GA45A
Growth arrest and DNA damage-inducible protein GADD45 alpha

1

0

High-throughput

0.299

High

967255

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

282934

NR1I2
Nuclear receptor subfamily 1 group I member 2

1

0

High-throughput

0.251

Low

885938

STAR
Steroidogenic acute regulatory protein, mitochondrial

1

0

Small-scale

0.251

Low

1009869

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

0

High-throughput

0.251

Low

140867

NOP56
Nucleolar protein 56

1

0

High-throughput

0.249

Low

1009874

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.249

Low

50537

HACL2
2-hydroxyacyl-CoA lyase 2

1

0

High-throughput

0.232

Low

1009829

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1009855

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.232

Low

1009858

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.232

Low

1009876

KXDL1
KxDL motif-containing protein 1

1

0

High-throughput

0.232

Low

1009890

APMAP
Adipocyte plasma membrane-associated protein

1

0

High-throughput

0.232

Low

1009898

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025