Protein: ANFB
Natriuretic peptides B (Brain natriuretic factor prohormone) (preproBNP) (proBNP) (Gamma-brain natriuretic peptide) (Iso-ANP) [Cleaved into: NT-proBNP (NT-pro-BNP) (NT-proBNP(1-76)); proBNP(3-108); Brain natriuretic peptide 32 (BNP(1-32)) (BNP-32) (Brain natriuretic peptide) (BNP); BNP(1-30); BNP(1-29); BNP(1-28); BNP(2-31); BNP(3-32) (des-SerPro-BNP) (proBNP(79-108)); BNP(3-30); BNP(3-29); Brain natriuretic peptide 29 (BNP(4-32)); BNP(4-31); BNP(4-30); BNP(4-29); BNP(4-27); BNP(5-32); BNP(5-31); BNP(5-29)]

Gene: ANFB, NPPB
Organism: Homo sapiens
Interactions: 148
UniProt ID: P16860

Gene Ontology (top 5):
GO:0003085 - negative regulation of systemic arterial blood pressure
GO:0003161 - cardiac conduction system development
GO:0005102 - signaling receptor binding
GO:0005179 - hormone activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

598684

ANPRC
Atrial natriuretic peptide receptor 3

4

2

Small-scale

0.882

High

598686

ANPRB
Atrial natriuretic peptide receptor 2

3

2

Small-scale

0.845

High

591197

ANPRA
Atrial natriuretic peptide receptor 1

2

2

Small-scale

0.778

High

598748

NT2NA
Notch homolog 2 N-terminal-like protein A

2

1

High-throughput

0.628

High

598713

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.580

High

598791

SRTD3
SERTA domain-containing protein 3

2

0

High-throughput

0.580

High

598690

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.549

High

598715

KR109
Keratin-associated protein 10-9

1

1

High-throughput

0.523

High

598725

EWS
RNA-binding protein EWS

1

0

High-throughput

0.518

High

168630

CSKP
Peripheral plasma membrane protein CASK

1

0

High-throughput

0.513

High

334380

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

598694

ITPI2
Protein ITPRID2

1

0

High-throughput

0.513

High

598735

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

High-throughput

0.513

High

598749

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.513

High

598752

RFLB
Refilin-B

1

0

High-throughput

0.513

High

281876

MPPB
Mitochondrial-processing peptidase subunit beta

1

1

High-throughput

0.489

High

598712

HDAC4
Histone deacetylase 4

1

0

Small-scale

0.480

High

365742

KAD1
Adenylate kinase isoenzyme 1

1

1

High-throughput

0.445

High

477398

CD63
CD63 antigen

1

1

High-throughput

0.445

High

489026

LKHA4
Leukotriene A-4 hydrolase

1

1

High-throughput

0.445

High

598687

CD9
CD9 antigen

1

1

High-throughput

0.445

High

598691

S10A4
Protein S100-A4

1

2

High-throughput

0.445

High

598692

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.445

High

598693

DPP4
Dipeptidyl peptidase 4

1

1

Small-scale

0.445

High

598698

ARL2
ADP-ribosylation factor-like protein 2

1

2

High-throughput

0.445

High

598703

GNPI1
Glucosamine-6-phosphate deaminase 1

1

1

High-throughput

0.445

High

598719

TYB10
Thymosin beta-10

1

1

High-throughput

0.445

High

598731

MPPA
Mitochondrial-processing peptidase subunit alpha

1

1

High-throughput

0.445

High

598732

SEPR
Prolyl endopeptidase FAP

1

1

Small-scale

0.445

High

598737

TSN
Translin

1

1

High-throughput

0.445

High

598760

S10AG
Protein S100-A16

1

2

High-throughput

0.445

High

598762

S10AD
Protein S100-A13

1

2

High-throughput

0.445

High

598763

TSNAX
Translin-associated protein X

1

1

High-throughput

0.445

High

598764

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.445

High

598770

EHD4
EH domain-containing protein 4

1

2

High-throughput

0.445

High

598771

AMPB
Aminopeptidase B

1

1

High-throughput

0.445

High

598773

EHD1
EH domain-containing protein 1

1

2

High-throughput

0.445

High

598786

EHD3
EH domain-containing protein 3

1

2

High-throughput

0.445

High

598714

KR103
Keratin-associated protein 10-3

1

1

High-throughput

0.439

High

123323

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.426

High

123983

SNP23
Synaptosomal-associated protein 23

1

0

High-throughput

0.426

High

135480

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.426

High

226696

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

0

High-throughput

0.426

High

300100

GLRX3
Glutaredoxin-3

1

0

High-throughput

0.426

High

334606

LYPA2
Acyl-protein thioesterase 2

1

0

High-throughput

0.426

High

458665

SAP
Prosaposin

1

0

High-throughput

0.426

High

479107

ENOG
Gamma-enolase

1

0

High-throughput

0.426

High

551686

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

568195

PLST
Plastin-3

1

0

High-throughput

0.426

High

598689

KTHY
Thymidylate kinase

1

0

High-throughput

0.426

High

598699

SYUA
Alpha-synuclein

1

0

High-throughput

0.426

High

598700

CAPG
Macrophage-capping protein

1

0

High-throughput

0.426

High

598701

CSK
Tyrosine-protein kinase CSK

1

0

High-throughput

0.426

High

598702

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.426

High

598708

DUS3
Dual specificity protein phosphatase 3

1

0

High-throughput

0.426

High

598718

TYB4
Thymosin beta-4

1

0

High-throughput

0.426

High

598720

SERB
Phosphoserine phosphatase

1

0

High-throughput

0.426

High

598721

NUCB2
Nucleobindin-2

1

0

High-throughput

0.426

High

598722

ATL3
ADAMTS-like protein 3

1

0

High-throughput

0.426

High

598723

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.426

High

598724

DHSO
Sorbitol dehydrogenase

1

0

High-throughput

0.426

High

598726

TAGL
Transgelin

1

0

High-throughput

0.426

High

598728

RHG01
Rho GTPase-activating protein 1

1

0

High-throughput

0.426

High

598730

PPID
Peptidyl-prolyl cis-trans isomerase D

1

0

High-throughput

0.426

High

598734

TTL12
Tubulin--tyrosine ligase-like protein 12

1

0

High-throughput

0.426

High

598736

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

High-throughput

0.426

High

598738

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.426

High

598739

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

0

High-throughput

0.426

High

598751

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.426

High

598758

RAB8B
Ras-related protein Rab-8B

1

0

High-throughput

0.426

High

598759

FERM2
Fermitin family homolog 2

1

0

High-throughput

0.426

High

598761

PGM2
Phosphopentomutase

1

0

High-throughput

0.426

High

598766

SH3G1
Endophilin-A2

1

0

High-throughput

0.426

High

598767

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.426

High

598769

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

High-throughput

0.426

High

598775

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.426

High

598776

PPCS
Phosphopantothenate--cysteine ligase

1

0

High-throughput

0.426

High

598777

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.426

High

598779

TIGAR
Fructose-2,6-bisphosphatase TIGAR

1

0

High-throughput

0.426

High

598781

SIAS
N-acetylneuraminate-9-phosphate synthase

1

0

High-throughput

0.426

High

598782

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.426

High

598785

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.426

High

598787

LMCD1
LIM and cysteine-rich domains protein 1

1

0

High-throughput

0.426

High

598788

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.426

High

598789

GRHPR
Glyoxylate reductase/hydroxypyruvate reductase

1

0

High-throughput

0.426

High

598790

PEF1
Peflin

1

0

High-throughput

0.426

High

598792

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.426

High

598793

MCTS1
Malignant T-cell-amplified sequence 1

1

0

High-throughput

0.426

High

598794

DD19B
ATP-dependent RNA helicase DDX19B

1

0

High-throughput

0.426

High

598797

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.426

High

598799

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

0

High-throughput

0.426

High

333804

6PGL
6-phosphogluconolactonase

1

1

High-throughput

0.407

High

520671

RRAS
Ras-related protein R-Ras

1

2

High-throughput

0.407

High

598685

RAB6A
Ras-related protein Rab-6A

1

2

High-throughput

0.407

High

598695

ECHM
Enoyl-CoA hydratase, mitochondrial

1

2

High-throughput

0.407

High

598707

RAB7A
Ras-related protein Rab-7a

1

1

High-throughput

0.407

High

598733

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

2

High-throughput

0.407

High

598744

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

2

High-throughput

0.407

High

598754

RAB2B
Ras-related protein Rab-2B

1

1

High-throughput

0.407

High

598768

RAB34
Ras-related protein Rab-34

1

1

High-throughput

0.407

High

598780

SAR1A
Small COPII coat GTPase SAR1A

1

1

High-throughput

0.407

High

70108

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

598742

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

65330

TCAF2
TRPM8 channel-associated factor 2

1

0

High-throughput

0.279

Low

598727

APLP2
Amyloid beta precursor like protein 2

1

0

High-throughput

0.279

Low

598740

NDUF5
Arginine-hydroxylase NDUFAF5, mitochondrial

1

0

High-throughput

0.279

Low

598746

FAT4
Protocadherin Fat 4

1

0

High-throughput

0.279

Low

598755

IASPP
RelA-associated inhibitor

1

0

High-throughput

0.279

Low

598784

C1GLT
Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

1

0

High-throughput

0.279

Low

598798

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

224853

MAAI
Maleylacetoacetate isomerase

1

0

High-throughput

0.232

Low

254518

EIF1B
Eukaryotic translation initiation factor 1b

1

0

High-throughput

0.232

Low

278620

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.232

Low

298139

DCTN3
Dynactin subunit 3

1

0

High-throughput

0.232

Low

333855

PAPS2
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 2

1

0

High-throughput

0.232

Low

360171

GSHR
Glutathione reductase, mitochondrial

1

0

High-throughput

0.232

Low

405395

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.232

Low

438949

DCUP
Uroporphyrinogen decarboxylase

1

0

High-throughput

0.232

Low

482143

RET1
Retinol-binding protein 1

1

0

High-throughput

0.232

Low

516936

GAL3A
Glutamine amidotransferase-like class 1 domain-containing protein 3, mitochondrial

1

0

High-throughput

0.232

Low

598688

CALB2
Calretinin

1

0

High-throughput

0.232

Low

598696

SPRE
Sepiapterin reductase

1

0

High-throughput

0.232

Low

598697

GLRX1
Glutaredoxin-1

1

0

High-throughput

0.232

Low

598704

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.232

Low

598705

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

0

High-throughput

0.232

Low

598706

GUAA
GMP synthase [glutamine-hydrolyzing]

1

0

High-throughput

0.232

Low

598709

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.232

Low

598710

MVD1
Diphosphomevalonate decarboxylase

1

0

High-throughput

0.232

Low

598711

ADK
Adenosine kinase

1

0

High-throughput

0.232

Low

598716

RAB5B
Ras-related protein Rab-5B

1

0

High-throughput

0.232

Low

598717

RAP1B
Ras-related protein Rap-1b

1

0

High-throughput

0.232

Low

598729

QOR
Quinone oxidoreductase

1

0

High-throughput

0.232

Low

598741

BROX
BRO1 domain-containing protein BROX

1

0

High-throughput

0.232

Low

598743

TM214
Transmembrane protein 214

1

0

High-throughput

0.232

Low

598745

FAH2B
Oxaloacetate tautomerase FAHD2B, mitochondrial

1

0

High-throughput

0.232

Low

598747

HSDL2
Hydroxysteroid dehydrogenase-like protein 2

1

0

High-throughput

0.232

Low

598750

TOM5
Mitochondrial import receptor subunit TOM5 homolog

1

0

High-throughput

0.232

Low

598753

LRC20
Leucine-rich repeat-containing protein 20

1

0

High-throughput

0.232

Low

598756

BRK1
Protein BRICK1

1

0

High-throughput

0.232

Low

598757

LZIC
Protein LZIC

1

0

High-throughput

0.232

Low

598765

SNAG
Gamma-soluble NSF attachment protein

1

0

High-throughput

0.232

Low

598772

E41L1
Band 4.1-like protein 1

1

0

High-throughput

0.232

Low

598774

DCTP1
dCTP pyrophosphatase 1

1

0

High-throughput

0.232

Low

598778

GLOD4
Glyoxalase domain-containing protein 4

1

0

High-throughput

0.232

Low

598783

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.232

Low

598795

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.232

Low

598796

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

598800

SNX8
Sorting nexin-8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025