Protein: MRPP3
Mitochondrial ribonuclease P catalytic subunit (EC 3.1.26.5) (Mitochondrial ribonuclease P protein 3) (Mitochondrial RNase P protein 3) (Protein only RNase P catalytic subunit)

Gene: MRPP3, PRORP
Organism: Homo sapiens
Interactions: 146
UniProt ID: O15091

Gene Ontology (top 5):
GO:0001682 - tRNA 5'-leader removal
GO:0004526 - ribonuclease P activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177551

OXLD1
Oxidoreductase-like domain-containing protein 1

3

0

High-throughput

0.638

High

177555

MRM1
rRNA methyltransferase 1, mitochondrial

3

0

High-throughput

0.638

High

177553

THEM4
Acyl-coenzyme A thioesterase THEM4

2

1

High-throughput

0.628

High

177562

TM10C
tRNA methyltransferase 10 homolog C

1

1

Small-scale

0.618

High

177495

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.602

High

177502

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

177564

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

177588

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.602

High

177520

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.586

High

177539

GRSF1
G-rich sequence factor 1

2

0

High-throughput

0.559

High

177543

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.547

High

177568

THEM5
Acyl-coenzyme A thioesterase THEM5

1

1

High-throughput

0.536

High

177569

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

1

High-throughput

0.536

High

177491

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

177498

ERAL1
GTPase Era, mitochondrial

1

0

High-throughput

0.513

High

177509

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

177515

S100P
Protein S100-P

1

0

High-throughput

0.513

High

177516

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

177518

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

0

High-throughput

0.513

High

177523

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

177527

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.513

High

177529

YBEY
Endoribonuclease YbeY

1

0

High-throughput

0.513

High

177557

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

177559

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

177566

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

177579

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

1

0

High-throughput

0.513

High

177580

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

177582

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.513

High

177589

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.513

High

177592

MYL10
Myosin regulatory light chain 10

1

0

High-throughput

0.513

High

177593

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

177604

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

177614

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

177615

NPS3A
Protein NipSnap homolog 3A

1

0

High-throughput

0.513

High

177618

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

177622

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.513

High

177623

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

177624

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

177626

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

0

High-throughput

0.513

High

177627

RT18B
Small ribosomal subunit protein mS40

1

0

High-throughput

0.513

High

177534

EFNB1
Ephrin-B1

1

1

High-throughput

0.489

High

177489

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

177497

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

177542

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.479

High

177545

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

High-throughput

0.479

High

177561

RHOU
Rho-related GTP-binding protein RhoU

1

5

High-throughput

0.479

High

177574

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

177575

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

177583

RHOV
Rho-related GTP-binding protein RhoV

1

5

High-throughput

0.479

High

177597

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

177600

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

177612

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

2

High-throughput

0.479

High

177616

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

61360

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.458

High

66083

MET15
12S rRNA N(4)-cytidine methyltransferase METTL15

1

0

High-throughput

0.458

High

177488

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

177494

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

177496

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

177499

XRP2
Protein XRP2

1

0

High-throughput

0.458

High

177503

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

177504

OTC
Ornithine transcarbamylase, mitochondrial

1

0

High-throughput

0.458

High

177508

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

177512

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

177513

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

177519

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

177521

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

177522

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

177528

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

177535

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

177536

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

177538

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

177540

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

High-throughput

0.458

High

177549

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

177552

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

177558

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

0

High-throughput

0.458

High

177573

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

177577

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

177578

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

177584

EFGM
Elongation factor G, mitochondrial

1

0

High-throughput

0.458

High

177586

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

177590

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

177595

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

177599

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

177605

NGRN
Neugrin

1

0

High-throughput

0.458

High

177606

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

177608

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

177610

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

177613

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

177617

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

177625

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

177505

FA12
Coagulation factor XII

1

1

High-throughput

0.437

High

177514

RAC2
Ras-related C3 botulinum toxin substrate 2

1

2

High-throughput

0.437

High

177525

RND2
Rho-related GTP-binding protein RhoN

1

3

High-throughput

0.437

High

177526

EFNB2
Ephrin-B2

1

1

High-throughput

0.437

High

177530

RHOA
Transforming protein RhoA

1

2

High-throughput

0.437

High

177532

RHOG
Rho-related GTP-binding protein RhoG

1

2

High-throughput

0.437

High

177547

RHOH
Rho-related GTP-binding protein RhoH

1

3

High-throughput

0.437

High

177601

RHOJ
Rho-related GTP-binding protein RhoJ

1

3

High-throughput

0.437

High

177581

AURKB
Aurora kinase B

1

0

High-throughput

0.426

High

177594

TR61B
tRNA

1

0

High-throughput

0.426

High

177609

ATD3A
ATPase family AAA domain-containing protein 3A

1

0

High-throughput

0.426

High

177611

TRM1
tRNA

1

0

High-throughput

0.426

High

177544

I13R2
Interleukin-13 receptor subunit alpha-2

2

0

High-throughput

0.328

High

177548

NTRK3
NT-3 growth factor receptor

2

0

High-throughput

0.328

High

177571

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

2

0

High-throughput

0.328

High

177490

COPT1
High affinity copper uptake protein 1

2

0

High-throughput

0.313

High

177554

FAXC
Failed axon connections homolog

2

0

High-throughput

0.313

High

71182

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

177487

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

177501

REC8
Meiotic recombination protein REC8 homolog

1

0

High-throughput

0.279

Low

177506

TGFA
Protransforming growth factor alpha [Cleaved into: Transforming growth factor alpha

1

0

High-throughput

0.279

Low

177517

IL1R2
Interleukin-1 receptor type 2

1

0

High-throughput

0.279

Low

177533

SHC2
SHC-transforming protein 2

1

0

High-throughput

0.279

Low

177541

KLRD1
Natural killer cells antigen CD94

1

0

High-throughput

0.279

Low

177567

IFT20
Intraflagellar transport protein 20 homolog

1

0

High-throughput

0.279

Low

177576

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.279

Low

177585

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

177587

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.279

Low

177596

SEM4C
Semaphorin-4C

1

0

High-throughput

0.279

Low

177603

B2L12
Bcl-2-like protein 12

1

0

High-throughput

0.279

Low

177607

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

177619

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

177621

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

0

High-throughput

0.279

Low

104859

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

177493

SCN2B
Sodium channel regulatory subunit beta-2

1

0

High-throughput

0.249

Low

177500

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

177507

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

177531

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

High-throughput

0.249

Low

177537

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.249

Low

177546

PTPRR
Receptor-type tyrosine-protein phosphatase R

1

0

High-throughput

0.249

Low

177560

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

177563

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

177570

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

177602

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

142238

PEX7
Peroxisomal targeting signal 2 receptor

1

0

High-throughput

0.232

Low

177492

GSDME
Gasdermin-E

1

0

High-throughput

0.232

Low

177510

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

177511

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

177524

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.232

Low

177550

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.232

Low

177556

MYORG
Myogenesis-regulating glycosidase

1

0

High-throughput

0.232

Low

177565

S22A9
Organic anion transporter 7

1

0

High-throughput

0.232

Low

177572

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

177591

FUZZY
Protein fuzzy homolog

1

0

High-throughput

0.232

Low

177598

DJC25
DnaJ homolog subfamily C member 25

1

0

High-throughput

0.232

Low

177620

PALD
Paladin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025