Protein: PURA
Transcriptional activator protein Pur-alpha (Purine-rich single-stranded DNA-binding protein alpha)

Gene: PURA
Organism: Homo sapiens
Interactions: 181
UniProt ID: Q00577

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000900 - mRNA regulatory element binding translation repressor activity
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

960583

PURG
Purine-rich element-binding protein gamma

1

5

High-throughput

0.691

High

960569

LN28A
Protein lin-28 homolog A

3

11

High-throughput

0.650

High

960496

PURA
Transcriptional activator protein Pur-alpha

1

5

Small-scale

0.647

High

369413

ESR1
Estrogen receptor

3

5

High-throughput

0.633

High

489004

H14
Histone H1.4

2

8

High-throughput

0.628

High

585444

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

2

2

High-throughput

0.628

High

960515

RRS1
Ribosome biogenesis regulatory protein homolog

2

2

High-throughput

0.628

High

960543

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

2

3

High-throughput

0.628

High

171760

WDR46
WD repeat-containing protein 46

2

3

High-throughput

0.611

High

717706

BMI1
Polycomb complex protein BMI-1

2

2

High-throughput

0.611

High

907283

RS8
Small ribosomal subunit protein eS8

2

2

High-throughput

0.611

High

960523

LARP7
La-related protein 7

2

7

High-throughput

0.611

High

960530

LN28B
Protein lin-28 homolog B

2

11

High-throughput

0.611

High

960497

E2F1
Transcription factor E2F1

2

1

Small-scale

0.602

High

496860

TAU
Microtubule-associated protein tau

2

3

High-throughput

0.601

High

374059

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

Small-scale

0.586

High

960532

MEPCE
7SK snRNA methylphosphate capping enzyme

2

1

High-throughput

0.584

High

960568

WDR76
WD repeat-containing protein 76

2

2

High-throughput

0.584

High

414247

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.554

High

180289

MAGB2
Melanoma-associated antigen B2

1

1

High-throughput

0.536

High

215337

U3IP2
U3 small nucleolar RNA-interacting protein 2

1

2

High-throughput

0.536

High

269698

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

8

High-throughput

0.536

High

273075

SURF6
Surfeit locus protein 6

1

1

High-throughput

0.536

High

281234

RL1D1
Ribosomal L1 domain-containing protein 1

1

1

High-throughput

0.536

High

400852

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.536

High

445369

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

470352

H2A1
Histone H2A type 1

1

4

High-throughput

0.536

High

559066

H15
Histone H1.5

1

8

High-throughput

0.536

High

559380

H13
Histone H1.3

1

8

High-throughput

0.536

High

559655

H12
Histone H1.2

1

8

High-throughput

0.536

High

616255

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

642298

RL13
Large ribosomal subunit protein eL13

1

1

High-throughput

0.536

High

736404

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

759616

RS19
Small ribosomal subunit protein eS19

1

1

High-throughput

0.536

High

790363

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

796545

KSYK
Tyrosine-protein kinase SYK

1

2

High-throughput

0.536

High

801087

KI67
Proliferation marker protein Ki-67

1

1

High-throughput

0.536

High

807328

RS10
Small ribosomal subunit protein eS10

1

2

High-throughput

0.536

High

830922

CTCF
Transcriptional repressor CTCF

1

11

High-throughput

0.536

High

875518

FGF8
Fibroblast growth factor 8

1

1

High-throughput

0.536

High

916144

RL23A
Large ribosomal subunit protein uL23

1

1

High-throughput

0.536

High

916521

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

922124

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.536

High

942598

SRPK2
SRSF protein kinase 2

1

10

High-throughput

0.536

High

944742

RED1
Double-stranded RNA-specific editase 1

1

3

High-throughput

0.536

High

951925

SRSF3
Serine/arginine-rich splicing factor 3

1

7

High-throughput

0.536

High

960499

H11
Histone H1.1

1

8

High-throughput

0.536

High

960500

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.536

High

960501

SRSF4
Serine/arginine-rich splicing factor 4

1

6

High-throughput

0.536

High

960504

SRSF5
Serine/arginine-rich splicing factor 5

1

7

High-throughput

0.536

High

960505

SRSF6
Serine/arginine-rich splicing factor 6

1

8

High-throughput

0.536

High

960508

KRR1
KRR1 small subunit processome component homolog

1

2

High-throughput

0.536

High

960509

CUL1
Cullin-1

1

3

High-throughput

0.536

High

960510

CUL3
Cullin-3

1

3

High-throughput

0.536

High

960517

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

3

High-throughput

0.536

High

960519

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

960521

H2A2C
Histone H2A type 2-C

1

4

High-throughput

0.536

High

960522

RN151
RING finger protein 151

1

2

High-throughput

0.536

High

960534

LYRIC
Protein LYRIC

1

1

High-throughput

0.536

High

960547

DYRK2
Dual specificity tyrosine-phosphorylation-regulated kinase 2

1

4

High-throughput

0.536

High

960553

NEIL1
Endonuclease 8-like 1

1

1

High-throughput

0.536

High

960556

ZN668
Zinc finger protein 668

1

9

High-throughput

0.536

High

960564

REXO4
RNA exonuclease 4

1

1

High-throughput

0.536

High

960572

ZNF71
Endothelial zinc finger protein induced by tumor necrosis factor alpha

1

6

High-throughput

0.536

High

960573

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.536

High

960578

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

2

High-throughput

0.536

High

960585

ZN346
Zinc finger protein 346

1

2

High-throughput

0.536

High

960587

ABT1
Activator of basal transcription 1

1

2

High-throughput

0.536

High

960589

SRPK3
SRSF protein kinase 3

1

8

High-throughput

0.536

High

960590

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

1

High-throughput

0.536

High

960591

YBOX2
Y-box-binding protein 2

1

10

High-throughput

0.536

High

960592

RBM19
Probable RNA-binding protein 19

1

4

High-throughput

0.536

High

914730

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

1

High-throughput

0.515

High

960582

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

577909

RL17
Large ribosomal subunit protein uL22

1

0

High-throughput

0.513

High

773327

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

842458

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.513

High

899156

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.513

High

945240

PRR3
Proline-rich protein 3

1

0

High-throughput

0.513

High

951517

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

960536

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

960546

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

960552

SGK3
Serine/threonine-protein kinase Sgk3

1

0

High-throughput

0.513

High

960558

MBB1A
Myb-binding protein 1A

1

0

High-throughput

0.513

High

960560

LLPH
Protein LLP homolog

1

0

High-throughput

0.513

High

960566

PLK3
Serine/threonine-protein kinase PLK3

1

0

High-throughput

0.513

High

960576

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.513

High

236749

CCNT1
Cyclin-T1

1

3

Small-scale

0.501

High

890608

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.501

High

960561

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

3

High-throughput

0.500

High

960516

P2RY6
P2Y purinoceptor 6

1

1

High-throughput

0.489

High

960529

SCYL2
SCY1-like protein 2

1

2

High-throughput

0.489

High

960538

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

2

High-throughput

0.489

High

174809

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

161814

ZN263
Zinc finger protein 263

1

11

Small-scale

0.479

High

227183

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

312573

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

326589

SNAI1
Zinc finger protein SNAI1

1

7

High-throughput

0.479

High

346536

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

349249

RASH
GTPase HRas

1

1

Small-scale

0.479

High

379299

MYCN
N-myc proto-oncogene protein

1

3

High-throughput

0.479

High

391656

H2A1B
Histone H2A type 1-B/E

1

4

High-throughput

0.479

High

435044

SP1
Transcription factor Sp1

1

8

Small-scale

0.479

High

442073

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

453292

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

3

High-throughput

0.479

High

472846

H2AB2
Histone H2A-Bbd type 2/3

1

6

High-throughput

0.479

High

475634

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.479

High

572622

VGFR1
Vascular endothelial growth factor receptor 1

1

2

High-throughput

0.479

High

575375

EGR1
Early growth response protein 1

1

12

Small-scale

0.479

High

707589

H2B1B
Histone H2B type 1-B

1

1

High-throughput

0.479

High

729264

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.479

High

760010

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

908384

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

917118

H4
Histone H4

1

1

High-throughput

0.479

High

959350

VIGLN
Vigilin

1

4

High-throughput

0.479

High

960498

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

960502

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

960503

TADBP
TAR DNA-binding protein 43

1

4

High-throughput

0.479

High

960506

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

960511

CUL4A
Cullin-4A

1

3

High-throughput

0.479

High

960513

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

960524

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

960525

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

960535

ZCH18
Zinc finger CCCH domain-containing protein 18

1

3

High-throughput

0.479

High

960537

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

2

High-throughput

0.479

High

960540

CGAS
Cyclic GMP-AMP synthase

1

1

High-throughput

0.479

High

960541

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

960549

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

960551

FUBP1
Far upstream element-binding protein 1

1

2

High-throughput

0.479

High

960570

RC3H2
Roquin-2

1

3

High-throughput

0.479

High

960571

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

960575

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

1

High-throughput

0.479

High

960579

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

3

High-throughput

0.479

High

960581

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

2

Small-scale

0.479

High

960584

AGO2
Protein argonaute-2

1

2

Small-scale

0.479

High

960588

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

960593

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

122666

MEN1
Menin

1

0

High-throughput

0.458

High

384656

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

595509

ITAX
Integrin alpha-X

1

0

Small-scale

0.458

High

914012

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

960507

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.458

High

960512

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

960520

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

960545

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

960550

IGSF8
Immunoglobulin superfamily member 8

1

0

High-throughput

0.458

High

960554

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

960555

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

960557

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

960580

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

47407

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.445

High

528981

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

905834

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.445

High

960548

ESR2
Estrogen receptor beta

1

5

High-throughput

0.445

High

960565

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

100683

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

960526

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.437

High

960531

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

960533

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.437

High

960559

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.437

High

960567

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.437

High

960574

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

960586

HECD1
E3 ubiquitin-protein ligase HECTD1

1

2

High-throughput

0.437

High

239942

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.426

High

401854

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

960563

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

69576

B0UZZ8
Chromosome 6 open reading frame 11

1

3

High-throughput

0.407

High

891081

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.407

High

960528

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.407

High

960544

Q8TE30
RNA-directed DNA polymerase

1

1

Small-scale

0.407

High

960518

SURF2
Surfeit locus protein 2

2

0

High-throughput

0.318

High

515268

KPSH1
Serine/threonine-protein kinase H1

1

0

High-throughput

0.279

Low

960514

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

960539

OTU6B
Deubiquitinase OTUD6B

1

0

Small-scale

0.269

Low

400048

ICAM1
Intercellular adhesion molecule 1

1

0

High-throughput

0.249

Low

782774

CSK
Tyrosine-protein kinase CSK

1

0

High-throughput

0.249

Low

960527

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

960562

TRI31
E3 ubiquitin-protein ligase TRIM31

1

0

High-throughput

0.249

Low

960577

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

960542

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024