Protein: MISP
Mitotic interactor and substrate of PLK1 (Mitotic spindle positioning protein)

Gene: MISP
Organism: Homo sapiens
Interactions: 173
UniProt ID: Q8IVT2

Gene Ontology (top 5):
GO:0000132 - establishment of mitotic spindle orientation
GO:0005884 - actin filament
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0005938 - cell cortex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

582868

EZRI
Ezrin

4

5

High-throughput

0.698

High

1309172

ANLN
Anillin

4

0

High-throughput

0.664

High

1280178

RABEK
Rab9 effector protein with kelch motifs

3

2

High-throughput

0.662

High

767468

RADI
Radixin

2

5

High-throughput

0.628

High

1309167

E41L1
Band 4.1-like protein 1

2

4

High-throughput

0.628

High

1309187

E41L3
Band 4.1-like protein 3

2

4

High-throughput

0.628

High

1063402

GOGA2
Golgin subfamily A member 2

2

3

High-throughput

0.606

High

1123030

FHL2
Four and a half LIM domains protein 2

2

2

High-throughput

0.606

High

1151571

TRIP6
Thyroid receptor-interacting protein 6

2

2

High-throughput

0.606

High

908138

KS6A3
Ribosomal protein S6 kinase alpha-3

3

2

High-throughput

0.604

High

1152143

MARE1
Microtubule-associated protein RP/EB family member 1

2

0

Small-scale

0.585

High

155168

SOCS7
Suppressor of cytokine signaling 7

2

0

High-throughput

0.580

High

217145

MS18B
Protein Mis18-beta

2

0

High-throughput

0.580

High

685255

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

928489

TERF1
Telomeric repeat-binding factor 1

2

0

High-throughput

0.580

High

963324

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.580

High

965767

HNRPK
Heterogeneous nuclear ribonucleoprotein K

2

0

High-throughput

0.580

High

1090770

TRAF2
TNF receptor-associated factor 2

2

0

High-throughput

0.580

High

1309143

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1309146

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

0

High-throughput

0.580

High

1309163

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.580

High

456784

ANXA2
Annexin A2

2

0

High-throughput

0.576

High

320567

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

2

5

High-throughput

0.574

High

1146433

KS6A2
Ribosomal protein S6 kinase alpha-2

2

2

High-throughput

0.574

High

1148357

KS6A1
Ribosomal protein S6 kinase alpha-1

2

2

High-throughput

0.574

High

1309151

KLDC3
Kelch domain-containing protein 3

2

3

High-throughput

0.574

High

1309189

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

2

2

High-throughput

0.574

High

1051019

FAK1
Focal adhesion kinase 1

1

3

Small-scale

0.561

High

681864

RBTN2
Rhombotin-2

2

2

High-throughput

0.553

High

682060

RBTN1
Rhombotin-1

2

2

High-throughput

0.553

High

1156302

HSPB2
Heat shock protein beta-2

2

1

High-throughput

0.553

High

1216131

FHL5
Four and a half LIM domains protein 5

2

2

High-throughput

0.553

High

1309134

PIHD2
PIH1 domain-containing protein 2

2

1

High-throughput

0.553

High

1309156

MLP3C
Microtubule-associated protein 1 light chain 3 gamma

2

1

High-throughput

0.553

High

1309176

PIHD1
PIH1 domain-containing protein 1

2

1

High-throughput

0.553

High

1309182

HSPB8
Heat shock protein beta-8

2

1

High-throughput

0.553

High

123759

MYO1C
Unconventional myosin-Ic

1

1

High-throughput

0.536

High

683865

MOES
Moesin

1

5

High-throughput

0.536

High

946248

ATS12
A disintegrin and metalloproteinase with thrombospondin motifs 12

1

1

High-throughput

0.536

High

968368

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

1

High-throughput

0.536

High

1309135

MY18A
Unconventional myosin-XVIIIa

1

1

High-throughput

0.536

High

1309142

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.536

High

1309174

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.536

High

891661

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.515

High

64884

RCCD1
RCC1 domain-containing protein 1

1

0

High-throughput

0.513

High

171729

GAK
Cyclin-G-associated kinase

1

0

High-throughput

0.513

High

231327

EFNA2
Ephrin-A2

1

0

High-throughput

0.513

High

261520

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

409588

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

0

High-throughput

0.513

High

457538

TBB5
Tubulin beta chain

1

0

High-throughput

0.513

High

480449

CD48
CD48 antigen

1

0

High-throughput

0.513

High

637616

FLNA
Filamin-A

1

0

High-throughput

0.513

High

772893

MYH9
Myosin-9

1

0

High-throughput

0.513

High

841565

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.513

High

862895

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.513

High

866751

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

941805

ARL4C
ADP-ribosylation factor-like protein 4C

1

0

High-throughput

0.513

High

958305

ARP2
Actin-related protein 2

1

0

High-throughput

0.513

High

1035521

CENPE
Centromere-associated protein E

1

0

High-throughput

0.513

High

1147367

EPHA7
Ephrin type-A receptor 7

1

0

High-throughput

0.513

High

1309127

SYNPO
Synaptopodin

1

0

High-throughput

0.513

High

1309170

CAN10
Calpain-10

1

0

High-throughput

0.513

High

1309173

MYO5C
Unconventional myosin-Vc

1

0

High-throughput

0.513

High

1309180

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.513

High

1309188

GPR55
G-protein coupled receptor 55

1

0

High-throughput

0.513

High

1309190

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

1309177

KLH14
Kelch-like protein 14

1

1

High-throughput

0.489

High

1309181

ATS1
A disintegrin and metalloproteinase with thrombospondin motifs 1

1

1

High-throughput

0.489

High

443431

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.480

High

223166

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

786708

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

1

High-throughput

0.479

High

891230

GSK3A
Glycogen synthase kinase-3 alpha

1

1

High-throughput

0.479

High

897331

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.479

High

1035756

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1123703

DCTN1
Dynactin subunit 1

1

1

Small-scale

0.479

High

1309138

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

1309166

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

1309179

TES
Testin

1

3

High-throughput

0.479

High

247375

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

564028

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

986547

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

1140518

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1161020

FSCN1
Fascin

1

0

High-throughput

0.458

High

1279191

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1309144

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

1309169

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1309171

WDR6
tRNA

1

1

High-throughput

0.445

High

331121

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

1137833

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.437

High

1309155

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

3

High-throughput

0.437

High

1309160

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

1

High-throughput

0.437

High

537468

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

839045

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

954968

S10AA
Protein S100-A10

1

0

High-throughput

0.426

High

1034021

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.426

High

1156676

NF2L2
Nuclear factor erythroid 2-related factor 2

1

0

High-throughput

0.426

High

1309132

MSPD2
Motile sperm domain-containing protein 2

1

0

High-throughput

0.426

High

1115792

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

2

High-throughput

0.407

High

272301

OBSL1
Obscurin-like protein 1

3

0

High-throughput

0.345

High

607701

DCAM
S-adenosylmethionine decarboxylase proenzyme

2

0

High-throughput

0.328

High

269271

HSF2B
Heat shock factor 2-binding protein

2

0

High-throughput

0.316

High

949586

KR123
Keratin-associated protein 12-3

2

0

High-throughput

0.316

High

1111091

SNW1
SNW domain-containing protein 1

2

0

High-throughput

0.316

High

1193231

SPAS1
Spermatogenesis-associated serine-rich protein 1

2

0

High-throughput

0.316

High

1203479

ACTMP
Actin maturation protease

2

0

High-throughput

0.316

High

1206399

EFHC2
EF-hand domain-containing family member C2

2

0

High-throughput

0.316

High

1218555

IKBP1
Interleukin-1 receptor-associated kinase 1-binding protein 1

2

0

High-throughput

0.316

High

1219576

MORN5
MORN repeat-containing protein 5

2

0

High-throughput

0.316

High

1236090

PRR5L
Proline-rich protein 5-like

2

0

High-throughput

0.316

High

1238540

RINT1
RAD50-interacting protein 1

2

0

High-throughput

0.316

High

1239081

CDPF1
Cysteine-rich DPF motif domain-containing protein 1

2

0

High-throughput

0.316

High

1244199

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.316

High

1244618

GASP3
G protein-coupled receptor associated sorting protein 3

2

0

High-throughput

0.316

High

1253061

ZN620
Zinc finger protein 620

2

0

High-throughput

0.316

High

1271184

DPPA4
Developmental pluripotency-associated protein 4

2

0

High-throughput

0.316

High

1309128

RIBC1
RIB43A-like with coiled-coils protein 1

2

0

High-throughput

0.316

High

1309133

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.316

High

1309145

CRBN
Protein cereblon

2

0

High-throughput

0.316

High

1309147

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.316

High

1309152

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.316

High

1309154

RUSC1
AP-4 complex accessory subunit RUSC1

2

0

High-throughput

0.316

High

1309161

SPC1L
Speriolin-like protein

2

0

High-throughput

0.316

High

1309164

GO45
Golgin-45

2

0

High-throughput

0.316

High

1309183

IKZF3
Zinc finger protein Aiolos

2

0

High-throughput

0.316

High

1309184

PNMA2
Paraneoplastic antigen Ma2

2

0

High-throughput

0.316

High

1118086

DX39B
Spliceosome RNA helicase DDX39B

2

0

Small-scale

0.305

High

1095035

DUS4
Dual specificity protein phosphatase 4

2

0

High-throughput

0.298

High

212970

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.279

Low

296803

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.279

Low

355369

B3GT4
Beta-1,3-galactosyltransferase 4

1

0

High-throughput

0.279

Low

908638

PRELP
Prolargin

1

0

High-throughput

0.279

Low

1034768

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

1160680

DREB
Drebrin

1

0

High-throughput

0.279

Low

1186176

INAVA
Innate immunity activator protein

1

0

High-throughput

0.279

Low

1204499

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1236104

FSTL4
Follistatin-related protein 4

1

0

High-throughput

0.279

Low

1309125

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

1309126

ZDH23
Palmitoyltransferase ZDHHC23

1

0

High-throughput

0.279

Low

1309129

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1309139

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

1309140

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

1309141

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.279

Low

1309149

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.279

Low

1309150

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1309159

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.279

Low

1309165

KLK15
Kallikrein-15

1

0

High-throughput

0.279

Low

1309168

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.279

Low

1309175

KLHL1
Kelch-like protein 1

1

0

High-throughput

0.279

Low

1309185

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

1148615

SF3A2
Splicing factor 3A subunit 2

1

0

High-throughput

0.268

Low

1239181

ZN774
Zinc finger protein 774

1

0

High-throughput

0.268

Low

1309131

BOLL
Protein boule-like

1

0

High-throughput

0.268

Low

1309130

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

129237

MEN1
Menin

1

0

High-throughput

0.249

Low

157583

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

247990

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

425563

ISG15
Ubiquitin-like protein ISG15

1

0

High-throughput

0.249

Low

979940

H4
Histone H4

1

0

High-throughput

0.249

Low

1004792

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

Small-scale

0.249

Low

1026456

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.249

Low

1205443

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

1254524

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1309136

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.249

Low

1309153

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

1309157

FACD2
Fanconi anemia group D2 protein

1

0

High-throughput

0.249

Low

1309158

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.249

Low

1309162

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1309178

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.249

Low

1309186

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.249

Low

964667

DCAF7
DDB1- and CUL4-associated factor 7

1

0

High-throughput

0.232

Low

1234851

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.232

Low

1309137

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

0

High-throughput

0.232

Low

1309148

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025