Protein: HPBP1
Hsp70-binding protein 1 (HspBP1) (Heat shock protein-binding protein 1) (Hsp70-binding protein 2) (HspBP2) (Hsp70-interacting protein 1) (Hsp70-interacting protein 2)

Gene: HPBP1, HSPBP1
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q9NZL4

Gene Ontology (top 5):
GO:0000774 - adenyl-nucleotide exchange factor activity
GO:0004857 - enzyme inhibitor activity
GO:0005615 - extracellular space
GO:0005783 - endoplasmic reticulum
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

538024

HSP7C
Heat shock cognate 71 kDa protein

13

10

Small-scale

0.762

High

931139

HSP72
Heat shock-related 70 kDa protein 2

9

7

High-throughput

0.692

High

1453409

CHIP
E3 ubiquitin-protein ligase CHIP

4

2

Small-scale

0.683

High

1026567

HSF1
Heat shock factor protein 1

6

6

High-throughput

0.671

High

1185232

EDRF1
Erythroid differentiation-related factor 1

5

1

High-throughput

0.654

High

761908

HSP74
Heat shock 70 kDa protein 4

2

8

Small-scale

0.629

High

1152751

ELF2
ETS-related transcription factor Elf-2

3

1

High-throughput

0.609

High

1360267

MT21A
Protein N-lysine methyltransferase METTL21A

3

1

High-throughput

0.609

High

600949

HSP76
Heat shock 70 kDa protein 6

3

8

High-throughput

0.599

High

535611

BIP
Endoplasmic reticulum chaperone BiP

2

11

Small-scale

0.595

High

169774

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

2

2

High-throughput

0.574

High

171773

GAK
Cyclin-G-associated kinase

2

1

High-throughput

0.574

High

273586

DJC13
DnaJ homolog subfamily C member 13

2

2

High-throughput

0.574

High

1044388

HSF2
Heat shock factor protein 2

2

6

High-throughput

0.574

High

1150835

SF01
Splicing factor 1

2

5

High-throughput

0.574

High

1180193

QRIC1
Transcriptional regulator QRICH1

2

3

High-throughput

0.574

High

1340682

NEDD1
Protein NEDD1

2

3

High-throughput

0.574

High

1277431

NT2NA
Notch homolog 2 N-terminal-like protein A

2

2

High-throughput

0.573

High

739038

ELF1
ETS-related transcription factor Elf-1

2

1

High-throughput

0.567

High

63048

POTEF
POTE ankyrin domain family member F

1

4

High-throughput

0.536

High

783673

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

3

High-throughput

0.536

High

1125707

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

2

High-throughput

0.536

High

1153128

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

1

High-throughput

0.536

High

1405809

TTC1
Tetratricopeptide repeat protein 1

1

4

High-throughput

0.536

High

1450959

KBTB4
Kelch repeat and BTB domain-containing protein 4

2

7

Small-scale

0.533

High

288158

PGRP1
Peptidoglycan recognition protein 1

1

0

Small-scale

0.527

High

655944

TBG1
Tubulin gamma-1 chain

2

3

High-throughput

0.521

High

858721

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

2

High-throughput

0.521

High

988768

RAC1
Ras-related C3 botulinum toxin substrate 1

2

7

High-throughput

0.521

High

214051

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

613475

VINC
Vinculin

1

0

High-throughput

0.513

High

1417761

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.513

High

423338

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

801566

HSPA9
Stress-70 protein, mitochondrial

1

14

Small-scale

0.501

High

724709

MK04
Mitogen-activated protein kinase 4

1

3

High-throughput

0.489

High

846799

GRK6
G protein-coupled receptor kinase 6

1

2

High-throughput

0.489

High

922521

CLH2
Clathrin heavy chain 2

1

2

High-throughput

0.489

High

943867

CF298
Cilia- and flagella-associated protein 298

1

1

High-throughput

0.489

High

1017501

FOXK1
Forkhead box protein K1

1

5

High-throughput

0.489

High

1091165

FOXC1
Forkhead box protein C1

1

8

High-throughput

0.489

High

1111323

SNW1
SNW domain-containing protein 1

1

1

High-throughput

0.489

High

1129525

PUM1
Pumilio homolog 1

1

1

High-throughput

0.489

High

1148662

SF3A2
Splicing factor 3A subunit 2

1

1

High-throughput

0.489

High

1178156

QSER1
Glutamine and serine-rich protein 1

1

2

High-throughput

0.489

High

1278133

MAVS
Mitochondrial antiviral-signaling protein

1

1

High-throughput

0.489

High

1287895

MTA70
N(6)-adenosine-methyltransferase catalytic subunit METTL3

1

1

High-throughput

0.489

High

1347880

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.489

High

1356651

IASPP
RelA-associated inhibitor

1

2

High-throughput

0.489

High

1368305

STAM1
Signal transducing adapter molecule 1

1

1

High-throughput

0.489

High

1385549

ULK4
Serine/threonine-protein kinase ULK4

1

2

High-throughput

0.489

High

1387414

ESS2
Splicing factor ESS-2 homolog

1

2

High-throughput

0.489

High

1390333

ZN503
Zinc finger protein 503

1

1

High-throughput

0.489

High

1432906

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

3

High-throughput

0.489

High

1434998

ILRUN
Protein ILRUN

1

1

High-throughput

0.489

High

1435900

ZN703
Zinc finger protein 703

1

1

High-throughput

0.489

High

1448691

LATS2
Serine/threonine-protein kinase LATS2

1

1

High-throughput

0.489

High

1449468

NRBP2
Nuclear receptor-binding protein 2

1

2

High-throughput

0.489

High

1453407

MKLN1
Muskelin

1

3

High-throughput

0.489

High

1453414

TACC3
Transforming acidic coiled-coil-containing protein 3

1

3

High-throughput

0.489

High

589894

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

728000

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

761527

HS71L
Heat shock 70 kDa protein 1-like

1

10

High-throughput

0.479

High

1107284

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1114491

CUL3
Cullin-3

1

9

High-throughput

0.479

High

1370954

TNR14
Tumor necrosis factor receptor superfamily member 14

1

3

High-throughput

0.479

High

1405890

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

1420893

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

5

High-throughput

0.479

High

1428394

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

3

High-throughput

0.479

High

831550

CCNF
Cyclin-F

1

4

High-throughput

0.470

High

1394375

Q96IS6
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.470

High

855782

CRK
Adapter molecule crk

1

0

High-throughput

0.458

High

1135611

UBX2B
UBX domain-containing protein 2B

1

0

High-throughput

0.458

High

1393774

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1418483

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1420146

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

0

Small-scale

0.458

High

1453406

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

889514

CLK1
Dual specificity protein kinase CLK1

1

8

High-throughput

0.457

High

951879

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

2

High-throughput

0.457

High

516178

HS71A
Heat shock 70 kDa protein 1A

1

8

High-throughput

0.445

High

516215

HS71B
Heat shock 70 kDa protein 1B

1

8

High-throughput

0.445

High

935204

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.445

High

1209739

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

351612

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

1

High-throughput

0.439

High

106756

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

218875

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

294444

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.437

High

412717

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

696713

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

769371

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

861814

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

Small-scale

0.437

High

971204

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

1098852

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

1

High-throughput

0.437

High

1178432

CL16A
Protein CLEC16A

1

3

High-throughput

0.437

High

1249274

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1255863

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

1307939

ARMC8
Armadillo repeat-containing protein 8

1

9

High-throughput

0.437

High

1327237

FBXL6
F-box/LRR-repeat protein 6

1

7

High-throughput

0.437

High

1337384

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.437

High

1434085

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.437

High

1435381

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

1436429

BRD9
Bromodomain-containing protein 9

1

12

High-throughput

0.437

High

1438931

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

1

High-throughput

0.437

High

1453404

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.437

High

1453408

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.437

High

1453416

DUS10
Dual specificity protein phosphatase 10

1

2

High-throughput

0.437

High

404933

PRIO
Major prion protein

1

0

High-throughput

0.426

High

1453415

ZNT1
Proton-coupled zinc antiporter SLC30A1

1

0

High-throughput

0.426

High

75614

B3KTT5
cDNA FLJ38698 fis, clone KIDNE2002015, highly similar to HEAT SHOCK 70 kDa PROTEIN 1

1

8

High-throughput

0.417

High

1217217

RIF1
Telomere-associated protein RIF1

1

3

High-throughput

0.417

High

97164

E9PQQ4
Heat shock protein family A

1

12

High-throughput

0.407

High

564464

CFTR
Cystic fibrosis transmembrane conductance regulator

1

4

High-throughput

0.407

High

1023901

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

2

High-throughput

0.407

High

1227594

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.407

High

1234989

PKHA7
Pleckstrin homology domain-containing family A member 7

1

8

High-throughput

0.407

High

1384543

Q96BE0
Heat shock cognate 71 kDa protein

1

11

High-throughput

0.407

High

1453411

S27A6
Long-chain fatty acid transport protein 6

1

2

High-throughput

0.407

High

1453412

WIPI2
WD repeat domain phosphoinositide-interacting protein 2

1

3

High-throughput

0.407

High

892278

5NTC
Cytosolic purine 5'-nucleotidase

4

0

High-throughput

0.360

High

920659

ARFP1
Arfaptin-1

2

0

High-throughput

0.328

High

1386169

FWCH2
FLYWCH family member 2

2

0

High-throughput

0.328

High

1391126

HMCES
Abasic site processing protein HMCES

2

0

High-throughput

0.328

High

1410484

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.328

High

1450814

ARMC1
Armadillo repeat-containing protein 1

2

0

High-throughput

0.328

High

1119533

PEBB
Core-binding factor subunit beta

2

0

High-throughput

0.318

High

1403360

RUFY1
RUN and FYVE domain-containing protein 1

2

0

High-throughput

0.318

High

1309975

CC117
Coiled-coil domain-containing protein 117

2

0

High-throughput

0.313

High

1212473

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

2

0

High-throughput

0.304

High

284357

GEMI
Geminin

1

0

High-throughput

0.279

Low

343651

OXSR1
Serine/threonine-protein kinase OSR1

1

0

High-throughput

0.279

Low

475031

VIME
Vimentin

1

0

High-throughput

0.279

Low

582122

PGAM2
Phosphoglycerate mutase 2

1

0

High-throughput

0.279

Low

644232

RS4Y1
Small ribosomal subunit protein eS4, Y isoform 1

1

0

High-throughput

0.279

Low

840989

ABL2
Tyrosine-protein kinase ABL2

1

0

High-throughput

0.279

Low

897090

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.279

Low

899718

ANX11
Annexin A11

1

0

High-throughput

0.279

Low

1088750

SF3A3
Splicing factor 3A subunit 3

1

0

High-throughput

0.279

Low

1213553

UBAP2
Ubiquitin-associated protein 2

1

0

High-throughput

0.279

Low

1435161

ESRP2
Epithelial splicing regulatory protein 2

1

0

High-throughput

0.279

Low

1446529

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

1453405

DBNL
Drebrin-like protein

1

0

High-throughput

0.279

Low

1453413

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.279

Low

1277645

K1C27
Keratin, type I cytoskeletal 27

1

0

High-throughput

0.251

Low

325139

HEXI1
Protein HEXIM1

1

0

High-throughput

0.249

Low

719378

MPIP3
M-phase inducer phosphatase 3

1

0

High-throughput

0.249

Low

1031571

IFM3
Interferon-induced transmembrane protein 3

1

0

High-throughput

0.249

Low

1127207

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

1252999

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.249

Low

1288507

LBN
Limbin

1

0

High-throughput

0.249

Low

1332720

ZBT38
Zinc finger and BTB domain-containing protein 38

1

0

Small-scale

0.249

Low

1339738

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

1380674

FBX32
F-box only protein 32

1

0

High-throughput

0.249

Low

1385706

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1399008

BROMI
Protein broad-minded

1

0

Small-scale

0.249

Low

1451290

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

1453410

FAN1
Fanconi-associated nuclease 1

1

0

High-throughput

0.249

Low

47887

A0AUL9
ATG2A protein

1

0

High-throughput

0.232

Low

870454

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

0

High-throughput

0.232

Low

933543

S12A3
Solute carrier family 12 member 3

1

0

High-throughput

0.232

Low

1108731

TBB3
Tubulin beta-3 chain

1

0

High-throughput

0.232

Low

1334288

S38A9
Neutral amino acid transporter 9

1

0

High-throughput

0.232

Low

1401550

S26A8
Testis anion transporter 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025