Protein: SYFM
Phenylalanine--tRNA ligase, mitochondrial (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase) (PheRS)

Gene: SYFM, FARS2
Organism: Homo sapiens
Interactions: 135
UniProt ID: O95363

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

329127

RCBT2
RCC1 and BTB domain-containing protein 2

3

1

High-throughput

0.675

High

334473

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

6

High-throughput

0.675

High

334475

IKZF3
Zinc finger protein Aiolos

3

1

High-throughput

0.675

High

334407

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

4

0

High-throughput

0.668

High

334474

DP13A
DCC-interacting protein 13-alpha

4

0

High-throughput

0.668

High

334370

ROA1
Heterogeneous nuclear ribonucleoprotein A1

4

0

High-throughput

0.661

High

334472

ZRAN1
Ubiquitin thioesterase ZRANB1

3

1

High-throughput

0.653

High

334411

GAMT
Guanidinoacetate N-methyltransferase

3

0

High-throughput

0.634

High

334401

H11
Histone H1.1

4

5

High-throughput

0.630

High

334391

KR107
Keratin-associated protein 10-7

3

5

High-throughput

0.616

High

334393

KR109
Keratin-associated protein 10-9

3

5

High-throughput

0.616

High

334422

K1C40
Keratin, type I cytoskeletal 40

3

4

High-throughput

0.616

High

334398

YBOX1
Y-box-binding protein 1

2

2

Small-scale

0.611

High

334409

CUL3
Cullin-3

2

2

High-throughput

0.611

High

334405

TRAF2
TNF receptor-associated factor 2

2

3

High-throughput

0.606

High

334408

GRB10
Growth factor receptor-bound protein 10

2

2

High-throughput

0.606

High

334416

TRIP6
Thyroid receptor-interacting protein 6

2

1

High-throughput

0.606

High

334439

KCD17
BTB/POZ domain-containing protein KCTD17

2

3

High-throughput

0.606

High

334440

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

334457

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

2

High-throughput

0.606

High

334451

RM38
Large ribosomal subunit protein mL38

2

0

High-throughput

0.602

High

334469

LN28A
Protein lin-28 homolog A

2

2

High-throughput

0.601

High

334441

BANP
Protein BANP

2

0

High-throughput

0.589

High

71159

HIG1C
HIG1 domain family member 1C

2

0

High-throughput

0.580

High

334363

BAG4
BAG family molecular chaperone regulator 4

2

0

High-throughput

0.580

High

334419

BEX5
Protein BEX5

2

0

High-throughput

0.580

High

334456

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

334458

MDFI
MyoD family inhibitor

2

0

High-throughput

0.580

High

334462

CDCA4
Cell division cycle-associated protein 4

2

0

High-throughput

0.580

High

334382

RS3
Small ribosomal subunit protein uS3

2

0

High-throughput

0.576

High

334400

RL19
Large ribosomal subunit protein eL19

2

0

High-throughput

0.576

High

334476

ZN346
Zinc finger protein 346

2

0

High-throughput

0.576

High

334373

H14
Histone H1.4

2

5

High-throughput

0.574

High

334381

H1T
Histone H1t

2

5

High-throughput

0.574

High

334375

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.573

High

334423

HMBX1
Homeobox-containing protein 1

1

2

High-throughput

0.573

High

334464

TRI54
Tripartite motif-containing protein 54

1

6

High-throughput

0.573

High

51389

FSD2
Fibronectin type III and SPRY domain-containing protein 2

2

7

High-throughput

0.553

High

245026

ZN500
Zinc finger protein 500

2

2

High-throughput

0.553

High

300275

KRT34
Keratin, type I cuticular Ha4

2

4

High-throughput

0.553

High

334392

KR108
Keratin-associated protein 10-8

2

5

High-throughput

0.553

High

334402

KRA11
Keratin-associated protein 1-1

2

5

High-throughput

0.553

High

334435

ZN438
Zinc finger protein 438

2

1

High-throughput

0.553

High

334445

IKBD
NF-kappa-B inhibitor delta

2

3

High-throughput

0.553

High

334454

AJUBA
LIM domain-containing protein ajuba

2

1

High-throughput

0.553

High

334465

BACH2
Transcription regulator protein BACH2

2

2

High-throughput

0.553

High

334467

KCNF1
Voltage-gated potassium channel regulatory subunit KCNF1

2

1

High-throughput

0.553

High

334434

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

334415

OASL
2'-5'-oligoadenylate synthase-like protein

1

3

High-throughput

0.536

High

334431

UBP45
Ubiquitin carboxyl-terminal hydrolase 45

1

3

High-throughput

0.536

High

334444

NEDD1
Protein NEDD1

1

1

High-throughput

0.536

High

334479

G3BP2
Ras GTPase-activating protein-binding protein 2

1

2

High-throughput

0.536

High

334480

YBOX2
Y-box-binding protein 2

1

2

High-throughput

0.536

High

334406

MKRN3
E3 ubiquitin-protein ligase makorin-3

1

1

High-throughput

0.523

High

334414

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.523

High

334385

TCPZ
T-complex protein 1 subunit zeta

1

2

High-throughput

0.515

High

334471

RIM3A
RIMS-binding protein 3A

1

1

High-throughput

0.515

High

334365

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

0

High-throughput

0.513

High

334376

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.513

High

334380

ANFB
Natriuretic peptides B

1

0

High-throughput

0.513

High

334384

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

334386

STA5A
Signal transducer and activator of transcription 5A

1

0

High-throughput

0.513

High

334387

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

334388

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.513

High

334395

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

334396

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

334397

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.513

High

334410

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

334425

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

334432

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.513

High

334436

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

334449

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.513

High

334453

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

334466

RM18
Large ribosomal subunit protein uL18m

1

0

High-throughput

0.513

High

182229

WDR46
WD repeat-containing protein 46

1

1

High-throughput

0.489

High

334372

GLI4
Zinc finger protein GLI4

1

2

High-throughput

0.489

High

334377

H15
Histone H1.5

1

5

High-throughput

0.489

High

334378

H13
Histone H1.3

1

5

High-throughput

0.489

High

334379

H12
Histone H1.2

1

5

High-throughput

0.489

High

334417

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

1

High-throughput

0.489

High

334477

ZN490
Zinc finger protein 490

1

1

High-throughput

0.489

High

66393

RIM3C
RIMS-binding protein 3C

1

1

High-throughput

0.481

High

240371

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

334367

ISG15
Ubiquitin-like protein ISG15

1

4

High-throughput

0.479

High

334383

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

334430

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

334468

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

49874

A1A4E9
Keratin 13

1

3

High-throughput

0.470

High

334390

KR105
Keratin-associated protein 10-5

1

5

High-throughput

0.470

High

334394

RL26
Large ribosomal subunit protein uL24

1

0

High-throughput

0.458

High

334482

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

334424

L2GL2
LLGL scribble cell polarity complex component 2

1

1

High-throughput

0.445

High

334374

K1C13
Keratin, type I cytoskeletal 13

1

3

High-throughput

0.439

High

334389

KR103
Keratin-associated protein 10-3

1

5

High-throughput

0.439

High

334420

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.438

High

334427

ATRAP
Type-1 angiotensin II receptor-associated protein

3

0

High-throughput

0.352

High

334452

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

3

0

High-throughput

0.352

High

334446

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

3

0

High-throughput

0.345

High

70065

CRTP1
Cysteine-rich tail protein 1

2

0

High-throughput

0.316

High

221308

SPY1
Protein sprouty homolog 1

2

0

High-throughput

0.316

High

325511

YIF1A
Protein YIF1A

2

0

High-throughput

0.316

High

334368

TPM2
Tropomyosin beta chain

2

0

High-throughput

0.316

High

334369

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

334403

AP1B1
AP-1 complex subunit beta-1

2

0

High-throughput

0.316

High

334412

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

334418

CC152
Coiled-coil domain-containing protein 152

2

0

High-throughput

0.316

High

334421

FHL5
Four and a half LIM domains protein 5

2

0

High-throughput

0.316

High

334426

MORN3
MORN repeat-containing protein 3

2

0

High-throughput

0.316

High

334429

DG2L6
Diacylglycerol O-acyltransferase 2-like protein 6

2

0

High-throughput

0.316

High

334442

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.316

High

334447

ZN526
Zinc finger protein 526

2

0

High-throughput

0.316

High

334448

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

0

High-throughput

0.316

High

334450

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.316

High

334459

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

2

0

High-throughput

0.316

High

334463

KRA33
Keratin-associated protein 3-3

2

0

High-throughput

0.316

High

334470

MA1C1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC

2

0

High-throughput

0.316

High

334478

ISY1
Pre-mRNA-splicing factor ISY1 homolog

2

0

High-throughput

0.316

High

334481

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

2

0

High-throughput

0.316

High

334399

PRR3
Proline-rich protein 3

2

0

High-throughput

0.313

High

283410

TAD2A
Transcriptional adapter 2-alpha

1

0

High-throughput

0.299

High

286613

STX11
Syntaxin-11

1

0

High-throughput

0.299

High

334404

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.299

High

334428

ATL4
ADAMTS-like protein 4

1

0

High-throughput

0.299

High

290407

SURF6
Surfeit locus protein 6

1

0

High-throughput

0.279

Low

334364

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.279

Low

334371

H2A1
Histone H2A type 1

1

0

High-throughput

0.279

Low

334413

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.279

Low

334433

CHSTF
Carbohydrate sulfotransferase 15

1

0

High-throughput

0.279

Low

334455

CC140
Coiled-coil domain-containing protein 140

1

0

High-throughput

0.279

Low

334460

LLPH
Protein LLP homolog

1

0

High-throughput

0.279

Low

334461

UTP23
rRNA-processing protein UTP23 homolog

1

0

High-throughput

0.279

Low

334437

HOMEZ
Homeobox and leucine zipper protein Homez

1

0

High-throughput

0.251

Low

334366

MYCN
N-myc proto-oncogene protein

1

0

High-throughput

0.249

Low

334438

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.249

Low

334443

SRFB1
Serum response factor-binding protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025