Protein: GRM5
Metabotropic glutamate receptor 5 (mGluR5)

Gene: GRM5
Organism: Homo sapiens
Interactions: 24
UniProt ID: P41594

Gene Ontology (top 5):
GO:0001640 - adenylate cyclase inhibiting G protein-coupled glutamate receptor activity
GO:0002029 - desensitization of G protein-coupled receptor signaling pathway
GO:0004930 - G protein-coupled receptor activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

835432

GRM5
Metabotropic glutamate receptor 5

1

14

Small-scale

0.666

High

835436

NMDZ1
Glutamate receptor ionotropic, NMDA 1

1

20

Small-scale

0.618

High

835437

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

20

Small-scale

0.618

High

555626

ACTN1
Alpha-actinin-1

1

2

Small-scale

0.561

High

835444

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.552

High

105497

APRIO
Alternative prion protein

1

5

Small-scale

0.512

High

603194

KPCA
Protein kinase C alpha type

1

8

Small-scale

0.501

High

835448

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

6

Small-scale

0.501

High

421652

A4
Amyloid-beta precursor protein

1

1

Small-scale

0.479

High

709243

AA2AR
Adenosine receptor A2a

1

6

Small-scale

0.479

High

835433

RGS4
Regulator of G-protein signaling 4

1

1

Small-scale

0.479

High

835435

CDK5
Cyclin-dependent kinase 5

1

1

Small-scale

0.479

High

835438

FRPD4
FERM and PDZ domain-containing protein 4

1

4

Small-scale

0.479

High

835439

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

835440

NECA2
N-terminal EF-hand calcium-binding protein 2

1

1

Small-scale

0.479

High

835441

GRASP
Protein TAMALIN

1

15

Small-scale

0.479

High

835443

HOME1
Homer protein homolog 1

1

10

Small-scale

0.479

High

835445

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

9

Small-scale

0.479

High

245313

CE104
Centrosomal protein of 104 kDa

1

0

High-throughput

0.458

High

835434

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

835442

LBN
Limbin

1

0

High-throughput

0.458

High

835447

NCDN
Neurochondrin

1

0

Small-scale

0.458

High

835446

MDN1
Midasin

1

2

High-throughput

0.437

High


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Last updated: 11Aug2025