Protein: LONP2
Lon protease homolog 2, peroxisomal (EC 3.4.21.53) (Lon protease-like protein 2) (Lon protease 2) (Peroxisomal Lon protease) (pLon)

Gene: LONP2
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q86WA8

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0004176 - ATP-dependent peptidase activity
GO:0004252 - serine-type endopeptidase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

242175

PRKN
E3 ubiquitin-protein ligase parkin

2

17

High-throughput

0.754

High

1105498

OS9
Protein OS-9

3

0

High-throughput

0.646

High

896266

PEX5
Peroxisomal targeting signal 1 receptor

3

4

Small-scale

0.631

High

699560

IL1R2
Interleukin-1 receptor type 2

2

1

High-throughput

0.628

High

1092994

CDC16
Cell division cycle protein 16 homolog

2

3

High-throughput

0.628

High

1292243

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

2

7

High-throughput

0.628

High

350061

SNAI1
Zinc finger protein SNAI1

1

6

High-throughput

0.618

High

1292233

MA7D2
MAP7 domain-containing protein 2

2

4

High-throughput

0.574

High

1292248

PCDA4
Protocadherin alpha-4

2

5

High-throughput

0.574

High

1292249

PCDAC
Protocadherin alpha-12

2

5

High-throughput

0.574

High

1292252

PCDA9
Protocadherin alpha-9

2

5

High-throughput

0.574

High

177392

ARHGB
Rho guanine nucleotide exchange factor 11

2

1

High-throughput

0.571

High

396442

ESR1
Estrogen receptor

2

17

High-throughput

0.571

High

1292231

RBCC1
RB1-inducible coiled-coil protein 1

2

4

High-throughput

0.571

High

399992

CATA
Catalase

2

0

High-throughput

0.563

High

1292242

RN181
E3 ubiquitin-protein ligase RNF181

2

3

High-throughput

0.549

High

1292253

PCDA8
Protocadherin alpha-8

2

5

High-throughput

0.549

High

1292254

PCDA3
Protocadherin alpha-3

2

5

High-throughput

0.549

High

132141

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

4

High-throughput

0.536

High

854142

KI67
Proliferation marker protein Ki-67

1

4

High-throughput

0.536

High

922266

LIMK1
LIM domain kinase 1

1

9

High-throughput

0.536

High

1161134

MK06
Mitogen-activated protein kinase 6

1

7

High-throughput

0.536

High

1197005

AMOT
Angiomotin

1

3

High-throughput

0.536

High

1292229

KIBRA
Protein KIBRA

1

6

High-throughput

0.536

High

1292235

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.536

High

1292237

WNK1
Serine/threonine-protein kinase WNK1

1

5

High-throughput

0.536

High

1292247

NXT1
NTF2-related export protein 1

1

3

High-throughput

0.536

High

1292251

NEUR2
Sialidase-2

1

1

High-throughput

0.536

High

212967

HS12A
Heat shock 70 kDa protein 12A

1

0

High-throughput

0.513

High

399507

C4BPA
C4b-binding protein alpha chain

1

1

High-throughput

0.489

High

1292255

PCDAB
Protocadherin alpha-11

1

5

High-throughput

0.489

High

122518

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

1

High-throughput

0.479

High

293954

CD123
Translation initiation factor eIF2 assembly protein

1

3

High-throughput

0.479

High

445947

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

1138367

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.479

High

1292232

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1292239

MTMRA
Myotubularin-related protein 10

1

1

High-throughput

0.479

High

1292241

WWOX
WW domain-containing oxidoreductase

1

7

High-throughput

0.479

High

1292246

FBW1B
F-box/WD repeat-containing protein 11

1

9

High-throughput

0.479

High

173020

XPO1
Exportin-1

1

1

High-throughput

0.445

High

1179762

TYSD1
Peroxisomal leader peptide-processing protease

1

5

Small-scale

0.445

High

106208

APRIO
Alternative prion protein

1

4

High-throughput

0.437

High

1254478

TRI67
Tripartite motif-containing protein 67

1

9

High-throughput

0.437

High

1292238

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1292256

S4A7
Sodium bicarbonate cotransporter 3

1

0

High-throughput

0.426

High

1231573

TBC3G
TBC1 domain family member 3G

1

2

High-throughput

0.407

High

1254223

TBCD9
TBC1 domain family member 9

1

1

High-throughput

0.407

High

1292236

RSPH9
Radial spoke head protein 9 homolog

4

0

High-throughput

0.363

High

1158650

IL17
Interleukin-17A

3

0

High-throughput

0.347

High

1292240

TMOD3
Tropomodulin-3

2

0

High-throughput

0.328

High

1292245

DKK3
Dickkopf-related protein 3

2

0

High-throughput

0.328

High

651601

IBP4
Insulin-like growth factor-binding protein 4

2

0

High-throughput

0.313

High

1228182

OLM2B
Olfactomedin-like protein 2B

2

0

High-throughput

0.313

High

342609

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

1249702

LYPD2
Ly6/PLAUR domain-containing protein 2

1

0

High-throughput

0.279

Low

1292234

RETNB
Resistin-like beta

1

0

High-throughput

0.279

Low

1292230

SYCE1
Synaptonemal complex central element protein 1

1

0

High-throughput

0.268

Low

458642

PGS2
Decorin

1

0

High-throughput

0.249

Low

87573

RBRP
Putative RNA-binding regulatory peptide

1

0

High-throughput

0.232

Low

653417

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1292244

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.232

Low

1292250

TMED5
Transmembrane emp24 domain-containing protein 5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025