Protein: ARG39
Rho guanine nucleotide exchange factor 39

Gene: ARG39, ARHGEF39
Organism: Homo sapiens
Interactions: 54
UniProt ID: Q8N4T4

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005886 - plasma membrane
GO:0030335 - positive regulation of cell migration

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

540049

BCR
Breakpoint cluster region protein

2

18

High-throughput

0.767

High

174259

ARHGA
Rho guanine nucleotide exchange factor 10

2

19

High-throughput

0.737

High

1326795

TIFA
TRAF-interacting protein with FHA domain-containing protein A

2

0

High-throughput

0.678

High

159743

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

7

High-throughput

0.625

High

1326809

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.618

High

1095708

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

3

20

High-throughput

0.609

High

635346

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

2

High-throughput

0.604

High

1326797

TRAF4
TNF receptor-associated factor 4

2

6

High-throughput

0.571

High

391351

FRIL
Ferritin light chain

2

2

High-throughput

0.549

High

1326796

KCD12
BTB/POZ domain-containing protein KCTD12

2

10

High-throughput

0.549

High

286243

CSDE1
Cold shock domain-containing protein E1

2

0

High-throughput

0.547

High

912959

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

14

High-throughput

0.536

High

1326803

ZN703
Zinc finger protein 703

1

2

High-throughput

0.536

High

175120

SC16A
Protein transport protein Sec16A

2

2

High-throughput

0.521

High

370338

CYTA
Cystatin-A

2

2

High-throughput

0.521

High

813477

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

2

1

High-throughput

0.521

High

973975

RUXF
Small nuclear ribonucleoprotein F

2

5

High-throughput

0.521

High

1157812

DDB1
DNA damage-binding protein 1

2

3

High-throughput

0.521

High

1323410

NUP93
Nuclear pore complex protein Nup93

2

4

High-throughput

0.521

High

1326794

FUBP1
Far upstream element-binding protein 1

2

13

High-throughput

0.521

High

1326802

HEAT1
HEAT repeat-containing protein 1

2

1

High-throughput

0.521

High

190434

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

479220

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

4

High-throughput

0.489

High

648200

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.489

High

729352

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

15

High-throughput

0.489

High

938755

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

13

High-throughput

0.489

High

1144072

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.489

High

1326792

PEX13
Peroxisomal membrane protein PEX13

1

10

High-throughput

0.489

High

1156151

ZYX
Zyxin

1

9

High-throughput

0.479

High

58872

PIPSL
Putative PIP5K1A and PSMD4-like protein

1

5

High-throughput

0.445

High

138218

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

6

High-throughput

0.437

High

187138

PPM1G
Protein phosphatase 1G

1

2

High-throughput

0.437

High

431186

LA
Lupus La protein

1

10

High-throughput

0.437

High

553841

KCRU
Creatine kinase U-type, mitochondrial

1

2

High-throughput

0.437

High

854689

RAGP1
Ran GTPase-activating protein 1

1

1

High-throughput

0.437

High

910989

IMA1
Importin subunit alpha-1

1

3

High-throughput

0.437

High

1097000

PRDX4
Peroxiredoxin-4

1

6

High-throughput

0.437

High

1131767

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.437

High

1326798

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

10

High-throughput

0.437

High

1326799

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.437

High

1326800

NSRP1
Nuclear speckle splicing regulatory protein 1

1

4

High-throughput

0.437

High

1326804

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.437

High

1326805

ANFY1
Rabankyrin-5

1

11

High-throughput

0.437

High

1326810

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

3

High-throughput

0.437

High

239131

ZNRD2
Protein ZNRD2

3

0

High-throughput

0.345

High

1326807

CCG5
Voltage-dependent calcium channel gamma-5 subunit

2

0

High-throughput

0.328

High

182157

PFD6
Prefoldin subunit 6

2

0

High-throughput

0.298

High

261837

PFD1
Prefoldin subunit 1

2

0

High-throughput

0.298

High

1326793

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.282

High

748700

CGL
Cystathionine gamma-lyase

1

0

High-throughput

0.279

Low

1179766

TYSD1
Peroxisomal leader peptide-processing protease

1

0

High-throughput

0.279

Low

1326806

AASS
Alpha-aminoadipic semialdehyde synthase, mitochondrial

1

0

High-throughput

0.279

Low

1326801

BOLA2
BolA-like protein 2

1

0

High-throughput

0.249

Low

1326808

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025