Protein: ACOX1
Peroxisomal acyl-coenzyme A oxidase 1 (AOX) (EC 1.3.3.6) (Palmitoyl-CoA oxidase) (Peroxisomal fatty acyl-CoA oxidase) (Straight-chain acyl-CoA oxidase) (SCOX) [Cleaved into: Peroxisomal acyl-CoA oxidase 1, A chain; Peroxisomal acyl-CoA oxidase 1, B chain; Peroxisomal acyl-CoA oxidase 1, C chain]

Gene: ACOX1
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q15067

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0003997 - acyl-CoA oxidase activity
GO:0005504 - fatty acid binding
GO:0005777 - peroxisome
GO:0005778 - peroxisomal membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

896240

PEX5
Peroxisomal targeting signal 1 receptor

4

6

Small-scale

0.671

High

982189

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

1

High-throughput

0.667

High

1141475

UBA5
Ubiquitin-like modifier-activating enzyme 5

3

0

High-throughput

0.634

High

1141481

RAB6B
Ras-related protein Rab-6B

2

5

High-throughput

0.628

High

352019

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

2

0

High-throughput

0.602

High

914029

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

2

0

High-throughput

0.602

High

1141456

MBNL2
Muscleblind-like protein 2

3

1

High-throughput

0.599

High

399975

CATA
Catalase

2

2

High-throughput

0.588

High

469734

GSTA1
Glutathione S-transferase A1

2

0

High-throughput

0.585

High

241728

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

326703

DUS14
Dual specificity protein phosphatase 14

2

1

High-throughput

0.574

High

1141448

RAB30
Ras-related protein Rab-30

2

2

High-throughput

0.574

High

1141455

KHDR2
KH domain-containing, RNA-binding, signal transduction-associated protein 2

2

1

High-throughput

0.574

High

1141462

ACBD7
Acyl-CoA-binding domain-containing protein 7

2

2

High-throughput

0.574

High

1141473

BOC
Brother of CDO

2

2

High-throughput

0.574

High

1141451

TYSD1
Peroxisomal leader peptide-processing protease

1

1

Small-scale

0.550

High

325320

OR2A4
Olfactory receptor 2A4

1

1

High-throughput

0.536

High

400858

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.536

High

479210

THIK
3-ketoacyl-CoA thiolase, peroxisomal

1

1

High-throughput

0.536

High

783101

ARL2
ADP-ribosylation factor-like protein 2

1

4

High-throughput

0.536

High

876329

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.536

High

912894

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

2

High-throughput

0.536

High

1036653

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

1

High-throughput

0.536

High

1141449

RB11B
Ras-related protein Rab-11B

1

2

High-throughput

0.536

High

1141460

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

2

High-throughput

0.536

High

1141477

E41L5
Band 4.1-like protein 5

1

2

High-throughput

0.536

High

1141480

MBNL1
Muscleblind-like protein 1

1

1

High-throughput

0.536

High

165766

PAHX
Phytanoyl-CoA dioxygenase, peroxisomal

1

0

High-throughput

0.513

High

842962

CDN2C
Cyclin-dependent kinase 4 inhibitor C

1

0

High-throughput

0.513

High

884451

PCY1A
Choline-phosphate cytidylyltransferase A

1

0

High-throughput

0.513

High

943054

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1141484

VATH
V-type proton ATPase subunit H

1

0

High-throughput

0.513

High

185714

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

1141457

LRC66
Leucine-rich repeat-containing protein 66

1

0

High-throughput

0.493

High

733353

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

1141478

SHCAF
SIN3-HDAC complex-associated factor

1

1

High-throughput

0.489

High

428777

RLA0
Large ribosomal subunit protein uL10

1

1

High-throughput

0.479

High

574096

GLUT4
Solute carrier family 2, facilitated glucose transporter member 4

1

6

High-throughput

0.479

High

888080

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

1106544

SMAD4
Mothers against decapentaplegic homolog 4

1

1

High-throughput

0.479

High

1141467

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1141479

ANLN
Anillin

1

2

High-throughput

0.479

High

1141483

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

1141485

DD19B
ATP-dependent RNA helicase DDX19B

1

2

High-throughput

0.479

High

942489

DHB7
3-keto-steroid reductase/17-beta-hydroxysteroid dehydrogenase 7

1

6

High-throughput

0.470

High

122501

ADAS
Alkyldihydroxyacetonephosphate synthase, peroxisomal

1

0

High-throughput

0.458

High

1141445

PLCB4
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

1

0

High-throughput

0.458

High

653325

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

890654

RGS3
Regulator of G-protein signaling 3

1

1

High-throughput

0.445

High

1052991

VMAT2
Synaptic vesicular amine transporter

1

5

High-throughput

0.445

High

1141446

CNN3
Calponin-3

1

1

High-throughput

0.445

High

1141454

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.445

High

1141471

PKP2
Plakophilin-2

1

1

High-throughput

0.445

High

1141476

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

1141486

GAB2
GRB2-associated-binding protein 2

1

1

High-throughput

0.445

High

588744

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

695509

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

768242

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

1141458

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1141463

PNMA1
Paraneoplastic antigen Ma1

1

1

High-throughput

0.437

High

1141464

TM171
Transmembrane protein 171

1

0

High-throughput

0.426

High

1141468

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.426

High

261175

NSMA
Sphingomyelin phosphodiesterase 2

1

1

High-throughput

0.407

High

330158

VENTX
Homeobox protein VENTX

1

1

High-throughput

0.407

High

926770

VMAT1
Chromaffin granule amine transporter

1

5

High-throughput

0.407

High

1141450

VACHT
Vesicular acetylcholine transporter

1

4

High-throughput

0.407

High

1141470

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

1

High-throughput

0.407

High

221937

FOXS1
Forkhead box protein S1

3

0

High-throughput

0.347

High

1141461

ATL1
ADAMTS-like protein 1

2

0

High-throughput

0.328

High

1141447

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

2

0

High-throughput

0.313

High

139062

LAD1
Ladinin-1

1

0

High-throughput

0.279

Low

1141452

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1141453

H1BP3
HCLS1-binding protein 3

1

0

High-throughput

0.279

Low

1141459

LHPL4
LHFPL tetraspan subfamily member 4 protein

1

0

High-throughput

0.279

Low

1141466

F136A
Protein FAM136A

1

0

High-throughput

0.279

Low

1141469

LITAF
Lipopolysaccharide-induced tumor necrosis factor-alpha factor

1

0

High-throughput

0.279

Low

1141472

CYREN
Cell cycle regulator of non-homologous end joining

1

0

High-throughput

0.279

Low

1141474

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.279

Low

1141482

TXD16
Thioredoxin domain-containing protein 16

1

0

High-throughput

0.279

Low

1141487

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

1141465

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025