Protein: OTU1
Ubiquitin thioesterase OTU1 (EC 3.4.19.12) (DUBA-8) (HIV-1-induced protease 7) (HIN-7) (HsHIN7) (OTU domain-containing protein 2)

Gene: OTU1, YOD1
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q5VVQ6

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0016236 - macroautophagy

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475896

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

7

3

Small-scale

0.967

High

875020

TERA
Transitional endoplasmic reticulum ATPase

6

2

Small-scale

0.734

High

1138860

UBXN6
UBX domain-containing protein 6

3

1

Small-scale

0.653

High

1138876

TRAF6
TNF receptor-associated factor 6

3

0

Small-scale

0.646

High

808160

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

1

Small-scale

0.629

High

398002

ISG15
Ubiquitin-like protein ISG15

1

3

Small-scale

0.618

High

1138837

SPART
Spartin

2

3

High-throughput

0.606

High

1138859

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

3

High-throughput

0.606

High

742345

SYUA
Alpha-synuclein

2

0

Small-scale

0.603

High

1138867

UBQL2
Ubiquilin-2

1

0

High-throughput

0.586

High

156309

PSA7
Proteasome subunit alpha type-7

2

0

High-throughput

0.580

High

638309

RBTN2
Rhombotin-2

2

0

High-throughput

0.580

High

722121

RFC2
Replication factor C subunit 2

2

0

High-throughput

0.580

High

1012257

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1065108

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.580

High

1138850

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

1138862

NGRN
Neugrin

2

0

High-throughput

0.580

High

1138864

ZFP57
Zinc finger protein 57 homolog

2

0

High-throughput

0.580

High

1138865

RN216
E3 ubiquitin-protein ligase RNF216

2

0

High-throughput

0.580

High

1138866

MKRN1
E3 ubiquitin-protein ligase makorin-1

2

0

High-throughput

0.580

High

1036282

BIRC2
Baculoviral IAP repeat-containing protein 2

1

1

High-throughput

0.536

High

1138856

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

High-throughput

0.536

High

985551

Q05BL1
TP53BP2 protein

1

1

High-throughput

0.515

High

565934

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.513

High

658379

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.513

High

686678

CCR1
C-C chemokine receptor type 1

1

0

High-throughput

0.513

High

882750

STX17
Syntaxin-17

1

0

High-throughput

0.513

High

1138845

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1138871

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

983152

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.501

High

1138847

TRI63
E3 ubiquitin-protein ligase TRIM63

1

3

High-throughput

0.501

High

1138857

TRI54
Tripartite motif-containing protein 54

1

2

High-throughput

0.501

High

1138858

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.501

High

1138868

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

1

High-throughput

0.501

High

1138875

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

1

High-throughput

0.501

High

1138854

RNF5
E3 ubiquitin-protein ligase RNF5

1

0

High-throughput

0.493

High

1138874

TBX22
T-box transcription factor TBX22

1

0

High-throughput

0.493

High

1035820

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

Small-scale

0.481

High

1043677

ASPP2
Apoptosis-stimulating of p53 protein 2

1

1

High-throughput

0.481

High

1138861

SHRPN
Sharpin

1

1

Small-scale

0.481

High

1038266

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

0

Small-scale

0.480

High

160620

AURKA
Aurora kinase A

1

1

Small-scale

0.479

High

808685

YAP1
Transcriptional coactivator YAP1

1

2

Small-scale

0.479

High

1138836

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

2

Small-scale

0.479

High

1138841

NPL4
Nuclear protein localization protein 4 homolog

1

1

Small-scale

0.479

High

1138846

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

1

Small-scale

0.479

High

1138853

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.479

High

1138869

AMFR
E3 ubiquitin-protein ligase AMFR

1

2

Small-scale

0.479

High

1138870

PLAP
Phospholipase A-2-activating protein

1

1

Small-scale

0.479

High

326678

SNAI1
Zinc finger protein SNAI1

1

0

Small-scale

0.458

High

487985

RARA
Retinoic acid receptor alpha

1

0

Small-scale

0.458

High

717155

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

818142

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1138833

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1138839

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

1138848

FAF2
FAS-associated factor 2

1

0

Small-scale

0.458

High

1138855

DERL1
Derlin-1

1

0

Small-scale

0.458

High

1138873

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

0

Small-scale

0.458

High

1138851

MITOK
Mitochondrial potassium channel

3

0

High-throughput

0.347

High

1138872

FCF1
rRNA-processing protein FCF1 homolog

2

0

High-throughput

0.328

High

1138844

F168A
Protein FAM168A

2

0

High-throughput

0.316

High

1138849

PKHB2
Pleckstrin homology domain-containing family B member 2

2

0

High-throughput

0.316

High

126009

UPK1A
Uroplakin-1a

1

0

High-throughput

0.279

Low

1103987

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1138838

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.279

Low

1138843

ZDH19
Palmitoyltransferase ZDHHC19

1

0

High-throughput

0.279

Low

1138852

THOC3
THO complex subunit 3

1

0

High-throughput

0.269

Low

1138863

PLS4
Phospholipid scramblase 4

1

0

High-throughput

0.268

Low

1138835

MAVS
Mitochondrial antiviral-signaling protein

1

0

Small-scale

0.249

Low

1138840

TXND5
Thioredoxin domain-containing protein 5

1

0

High-throughput

0.249

Low

1138842

BL1S5
Biogenesis of lysosome-related organelles complex 1 subunit 5

1

0

High-throughput

0.249

Low

1138834

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024