Protein: SPRE
Sepiapterin reductase (SPR) (EC 1.1.1.153)

Gene: SPRE, SPR
Organism: Homo sapiens
Interactions: 50
UniProt ID: P35270

Gene Ontology (top 5):
GO:0004757 - sepiapterin reductase (NADP+) activity
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

387800

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

1

3

High-throughput

0.536

High

770447

BAP31
B-cell receptor-associated protein 31

1

3

High-throughput

0.515

High

144047

MA2B1
Lysosomal alpha-mannosidase

1

0

High-throughput

0.513

High

690780

1433T
14-3-3 protein theta

1

1

High-throughput

0.501

High

438933

CD5
T-cell surface glycoprotein CD5

1

2

High-throughput

0.489

High

770448

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

136058

PLK4
Serine/threonine-protein kinase PLK4

1

1

High-throughput

0.479

High

169981

AURKA
Aurora kinase A

1

1

High-throughput

0.479

High

176153

PER2
Period circadian protein homolog 2

1

1

Small-scale

0.479

High

362187

ABL1
Tyrosine-protein kinase ABL1

1

6

High-throughput

0.479

High

371322

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

439664

INSR
Insulin receptor

1

1

High-throughput

0.479

High

440411

FYN
Tyrosine-protein kinase Fyn

1

6

High-throughput

0.479

High

463004

YES
Tyrosine-protein kinase Yes

1

6

High-throughput

0.479

High

463376

LYN
Tyrosine-protein kinase Lyn

1

6

High-throughput

0.479

High

536618

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

557139

SRC
Proto-oncogene tyrosine-protein kinase Src

1

6

High-throughput

0.479

High

588046

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

694760

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

767541

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

770444

TEC
Tyrosine-protein kinase Tec

1

6

High-throughput

0.479

High

770445

ABL2
Tyrosine-protein kinase ABL2

1

6

High-throughput

0.479

High

770449

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

770456

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

770462

ATG5
Autophagy protein 5

1

1

High-throughput

0.479

High

770466

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

770452

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

770453

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

770454

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

330059

VENTX
Homeobox protein VENTX

1

3

High-throughput

0.445

High

653159

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

770451

RM49
Large ribosomal subunit protein mL49

1

1

High-throughput

0.445

High

770459

RNF31
E3 ubiquitin-protein ligase RNF31

1

7

High-throughput

0.445

High

770460

SYMM
Methionine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

770463

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.445

High

770464

DDX28
Probable ATP-dependent RNA helicase DDX28

1

1

High-throughput

0.445

High

465431

IGF1R
Insulin-like growth factor 1 receptor

1

1

High-throughput

0.437

High

770455

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

125276

LEG9
Galectin-9

1

0

High-throughput

0.426

High

326881

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.426

High

770457

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.426

High

770458

HPS1
BLOC-3 complex member HPS1

1

0

High-throughput

0.426

High

770461

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

770467

GAB2
GRB2-associated-binding protein 2

1

0

High-throughput

0.426

High

770446

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

770465

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

770468

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

598696

ANFB
Natriuretic peptides B

1

0

High-throughput

0.232

Low

689805

CD27
CD27 antigen

1

0

High-throughput

0.232

Low

770450

SSBP2
Single-stranded DNA-binding protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025