Protein: HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)

Gene: HEM6, CPOX
Organism: Homo sapiens
Interactions: 56
UniProt ID: P36551

Gene Ontology (top 5):
GO:0004109 - coproporphyrinogen oxidase activity
GO:0005212 - structural constituent of eye lens
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

784850

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

2

High-throughput

0.618

High

348396

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

559891

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

784883

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

784855

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.518

High

784860

CUL3
Cullin-3

1

0

High-throughput

0.513

High

784869

STYX
Serine/threonine/tyrosine-interacting protein

1

0

Small-scale

0.513

High

240927

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

292085

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.479

High

784859

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

784875

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

784876

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

784880

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

784888

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

125284

LEG9
Galectin-9

1

0

High-throughput

0.458

High

216639

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

296207

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

315210

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

341533

EYA4
Protein phosphatase EYA4

1

0

High-throughput

0.458

High

536628

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

567204

PPA5
Tartrate-resistant acid phosphatase type 5

1

0

High-throughput

0.458

High

784851

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

784852

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

784853

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

784854

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

784856

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

784857

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

784861

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

784862

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

784866

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

784868

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

784872

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

784873

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

784874

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

784877

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

784878

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

784879

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

784881

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

784882

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

784884

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

784885

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

784887

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

784865

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

1

High-throughput

0.445

High

354572

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

653166

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

784858

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

784864

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

784871

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.426

High

784886

DDX28
Probable ATP-dependent RNA helicase DDX28

1

0

High-throughput

0.426

High

784889

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

587016

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

784863

SKDA1
SKI/DACH domain-containing protein 1

1

0

High-throughput

0.249

Low

784870

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

429419

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

784867

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025