Protein: LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial (EC 3.4.-.-)

Gene: LACTB
Organism: Homo sapiens
Interactions: 170
UniProt ID: P83111

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006629 - lipid metabolic process
GO:0008233 - peptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1013378

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

1

High-throughput

0.618

High

348462

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.613

High

559932

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

3

0

High-throughput

0.613

High

553805

KCRU
Creatine kinase U-type, mitochondrial

2

1

High-throughput

0.611

High

507830

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

1

High-throughput

0.602

High

1013461

COPRS
Coordinator of PRMT5 and differentiation stimulator

2

0

High-throughput

0.602

High

292114

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

2

1

High-throughput

0.584

High

1013424

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

1013457

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

1013462

ANLN
Anillin

2

0

High-throughput

0.559

High

413616

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

605135

KCRS
Creatine kinase S-type, mitochondrial

1

1

High-throughput

0.536

High

1013420

KCTD6
BTB/POZ domain-containing protein KCTD6

1

2

High-throughput

0.536

High

1013445

NPS3B
Protein NipSnap homolog 3B

1

1

High-throughput

0.536

High

1013474

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

391223

FRIL
Ferritin light chain

1

0

High-throughput

0.513

High

578653

GLNA
Glutamine synthetase

1

0

High-throughput

0.513

High

635309

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.513

High

716531

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

0

High-throughput

0.513

High

733841

CDD
Cytidine deaminase

1

0

High-throughput

0.513

High

765385

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.513

High

861481

GNPI1
Glucosamine-6-phosphate deaminase 1

1

0

High-throughput

0.513

High

961594

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.513

High

1013386

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.513

High

1013390

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

0

High-throughput

0.513

High

1013392

TSN
Translin

1

0

High-throughput

0.513

High

1013393

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.513

High

1013415

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1013443

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.513

High

1013476

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

0

High-throughput

0.513

High

185610

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

1013395

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.493

High

388513

CRP

1

1

High-throughput

0.489

High

868972

NPTX2
Neuronal pentraxin-2

1

1

High-throughput

0.489

High

1013418

KCD17
BTB/POZ domain-containing protein KCTD17

1

2

High-throughput

0.489

High

1013470

IBTK
Inhibitor of Bruton tyrosine kinase

1

1

High-throughput

0.489

High

131945

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

222937

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

238706

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

1

High-throughput

0.479

High

318003

TOM70
Mitochondrial import receptor subunit TOM70

1

1

High-throughput

0.479

High

342826

HERC2
E3 ubiquitin-protein ligase HERC2

1

2

High-throughput

0.479

High

766445

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

786070

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

999304

UBX2A
UBX domain-containing protein 2A

1

2

High-throughput

0.479

High

1013381

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1013388

UBX2B
UBX domain-containing protein 2B

1

2

High-throughput

0.479

High

1013399

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.479

High

1013401

MARC1
Mitochondrial amidoxime-reducing component 1

1

1

High-throughput

0.479

High

1013403

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

1

High-throughput

0.479

High

1013407

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.479

High

1013416

MICU2
Calcium uptake protein 2, mitochondrial

1

2

High-throughput

0.479

High

1013427

MARC2
Mitochondrial amidoxime reducing component 2

1

1

High-throughput

0.479

High

1013429

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.479

High

1013436

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1013439

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1013441

PHB2
Prohibitin-2

1

1

High-throughput

0.479

High

1013442

MICU1
Calcium uptake protein 1, mitochondrial

1

2

High-throughput

0.479

High

1013447

MIC26
MICOS complex subunit MIC26

1

1

High-throughput

0.479

High

1013451

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.479

High

1013452

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

1

Small-scale

0.479

High

1013453

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

2

High-throughput

0.479

High

1013467

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.479

High

1013475

NSF1C
NSFL1 cofactor p47

1

2

High-throughput

0.479

High

1013479

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

71720

NUD19
Acyl-coenzyme A diphosphatase NUDT19

1

0

High-throughput

0.458

High

124304

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

127481

NDUS8
NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial

1

0

High-throughput

0.458

High

143825

NDKM
Nucleoside diphosphate kinase, mitochondrial

1

0

High-throughput

0.458

High

157237

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

216667

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

245455

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

281581

MTX2
Metaxin-2

1

0

High-throughput

0.458

High

296229

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

329246

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

345667

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

353934

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.458

High

400649

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

528437

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.458

High

592832

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.458

High

605993

CAN2
Calpain-2 catalytic subunit

1

0

High-throughput

0.458

High

634094

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

647433

SCP2
Sterol carrier protein 2

1

0

High-throughput

0.458

High

733906

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

0

High-throughput

0.458

High

784856

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

828748

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

872199

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

883217

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

909427

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

922722

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

932460

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

947162

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

978866

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1013379

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1013382

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1013383

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1013387

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.458

High

1013389

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1013391

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.458

High

1013394

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1013396

MIX23
Protein MIX23

1

0

High-throughput

0.458

High

1013397

PREP
Presequence protease, mitochondrial

1

0

High-throughput

0.458

High

1013400

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1013406

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

0

High-throughput

0.458

High

1013410

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1013412

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1013413

DCXR
L-xylulose reductase

1

0

High-throughput

0.458

High

1013417

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

0

High-throughput

0.458

High

1013419

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

1013421

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1013425

KAT2B
Histone acetyltransferase KAT2B

1

0

High-throughput

0.458

High

1013426

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1013430

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1013431

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

1013433

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

1013435

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

1013440

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

1013446

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.458

High

1013448

B2L13
Bcl-2-like protein 13

1

0

High-throughput

0.458

High

1013450

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1013454

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1013455

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1013456

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1013460

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.458

High

1013463

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

1013464

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1013465

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

1013466

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.458

High

1013468

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

1013469

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

1013472

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

1013477

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1013478

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

395899

ESR1
Estrogen receptor

1

1

High-throughput

0.445

High

1013404

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1013405

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

1

1

High-throughput

0.445

High

1013409

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.439

High

330867

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.437

High

1013402

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1013414

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

0

High-throughput

0.426

High

1013434

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

1013437

VPS35
Vacuolar protein sorting-associated protein 35

1

0

Small-scale

0.426

High

1013438

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

1013428

C102A
Coiled-coil domain-containing protein 102A

2

0

High-throughput

0.324

High

186842

FOXN1
Forkhead box protein N1

1

0

High-throughput

0.279

Low

547997

PSPC
Surfactant protein C

1

0

High-throughput

0.279

Low

1013458

NMNA1
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1

1

0

High-throughput

0.279

Low

1013471

ZNFX1
NFX1-type zinc finger-containing protein 1

1

0

High-throughput

0.279

Low

1013480

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

477228

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

0

High-throughput

0.269

Low

1013411

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.269

Low

1013423

MY18A
Unconventional myosin-XVIIIa

1

0

High-throughput

0.269

Low

1013444

TCAL7
Transcription elongation factor A protein-like 7

1

0

High-throughput

0.269

Low

522649

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

Small-scale

0.251

Low

105755

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

315460

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.249

Low

371755

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

378057

TNFA
Tumor necrosis factor

1

0

High-throughput

0.249

Low

1013380

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

1013385

CUL4A
Cullin-4A

1

0

High-throughput

0.249

Low

1013398

MARH8
E3 ubiquitin-protein ligase MARCHF8

1

0

High-throughput

0.249

Low

1013408

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1013432

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1013459

DNJC4
DnaJ homolog subfamily C member 4

1

0

High-throughput

0.249

Low

254964

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

389813

TTHY
Transthyretin

1

0

High-throughput

0.232

Low

1013384

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.232

Low

1013422

MOT10
Monocarboxylate transporter 10

1

0

High-throughput

0.232

Low

1013449

S39A8
Metal cation symporter ZIP8

1

0

High-throughput

0.232

Low

1013473

SL9A2
Sodium/hydrogen exchanger 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025