Protein: OMA1
Metalloendopeptidase OMA1, mitochondrial (EC 3.4.24.-) (Metalloprotease-related protein 1) (MPRP-1) (Overlapping with the m-AAA protease 1 homolog)

Gene: OMA1
Organism: Homo sapiens
Interactions: 157
UniProt ID: Q96E52

Gene Ontology (top 5):
GO:0002024 - diet induced thermogenesis
GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1242897

S39A4
Zinc transporter ZIP4

4

0

High-throughput

0.661

High

348652

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.613

High

1388589

TOR3A
Torsin-3A

3

1

High-throughput

0.609

High

1388581

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

3

1

High-throughput

0.604

High

50924

SYCE3
Synaptonemal complex central element protein 3

2

0

High-throughput

0.602

High

163582

TPP1
Tripeptidyl-peptidase 1

2

0

High-throughput

0.602

High

1388579

MIC26
MICOS complex subunit MIC26

2

1

High-throughput

0.584

High

854571

S15A1
Solute carrier family 15 member 1

2

1

High-throughput

0.574

High

1235727

SCMC2
Mitochondrial adenyl nucleotide antiporter SLC25A25

2

3

High-throughput

0.571

High

560045

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

1388591

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

250132

ADCY9
Adenylate cyclase type 9

1

1

High-throughput

0.536

High

818879

ADCY8
Adenylate cyclase type 8

1

1

High-throughput

0.536

High

212086

B4GT5
Beta-1,4-galactosyltransferase 5

1

0

High-throughput

0.513

High

1277983

KCNKI
Potassium channel subfamily K member 18

1

0

High-throughput

0.513

High

227257

KRT86
Keratin, type II cuticular Hb6

1

1

High-throughput

0.489

High

640446

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

1

High-throughput

0.489

High

1127822

KRT81
Keratin, type II cuticular Hb1

1

1

High-throughput

0.489

High

1365485

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.489

High

238733

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

1

High-throughput

0.479

High

281635

MTX2
Metaxin-2

1

1

High-throughput

0.479

High

292194

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

2

High-throughput

0.479

High

1108450

MTX1
Metaxin-1

1

1

High-throughput

0.479

High

1201321

OCAD2
OCIA domain-containing protein 2

1

1

High-throughput

0.479

High

1214746

ATD3B
ATPase family AAA domain-containing protein 3B

1

1

High-throughput

0.479

High

1238285

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

2

High-throughput

0.479

High

1245984

ZNT9
Proton-coupled zinc antiporter SLC30A9, mitochondrial

1

1

High-throughput

0.479

High

1250098

MIC27
MICOS complex subunit MIC27

1

1

High-throughput

0.479

High

1315591

MICU2
Calcium uptake protein 2, mitochondrial

1

2

High-throughput

0.479

High

1388571

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

1388572

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.479

High

1388573

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.479

High

1388575

MICU1
Calcium uptake protein 1, mitochondrial

1

2

High-throughput

0.479

High

1388577

MIC25
MICOS complex subunit MIC25

1

1

High-throughput

0.479

High

1388583

CLPB
Mitochondrial disaggregase

1

1

High-throughput

0.479

High

1388585

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.479

High

1388598

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.479

High

1388599

OCAD1
OCIA domain-containing protein 1

1

1

High-throughput

0.479

High

1388600

MIC19
MICOS complex subunit MIC19

1

1

High-throughput

0.479

High

1388612

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.479

High

1388614

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

1

High-throughput

0.479

High

747

A0A087WYV9
Cytochrome c oxidase assembly protein COX16 homolog, mitochondrial

1

0

High-throughput

0.458

High

124439

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

223641

NDUB5
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial

1

0

High-throughput

0.458

High

245515

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

High-throughput

0.458

High

275717

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.458

High

296279

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

318041

TOM70
Mitochondrial import receptor subunit TOM70

1

0

High-throughput

0.458

High

329327

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.458

High

353968

NDUBA
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.458

High

397695

NU4M
NADH-ubiquinone oxidoreductase chain 4

1

0

High-throughput

0.458

High

471680

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

High-throughput

0.458

High

485881

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.458

High

528496

COX5B
Cytochrome c oxidase subunit 5B, mitochondrial

1

0

High-throughput

0.458

High

553853

KCRU
Creatine kinase U-type, mitochondrial

1

0

High-throughput

0.458

High

622242

NDUV2
NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial

1

0

High-throughput

0.458

High

634153

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.458

High

702650

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

0

High-throughput

0.458

High

784872

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.458

High

847430

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

887455

CEBPD
CCAAT/enhancer-binding protein delta

1

0

Small-scale

0.458

High

909461

NDUA8
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8

1

0

High-throughput

0.458

High

922758

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.458

High

932497

KAD2
Adenylate kinase 2, mitochondrial

1

0

High-throughput

0.458

High

940043

NDUV3
NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial

1

0

High-throughput

0.458

High

1013431

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

1023594

CYC
Cytochrome c

1

0

High-throughput

0.458

High

1124784

NUCG
Endonuclease G, mitochondrial

1

0

High-throughput

0.458

High

1164507

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

1196942

MIX23
Protein MIX23

1

0

High-throughput

0.458

High

1215609

ATPF1
ATP synthase mitochondrial F1 complex assembly factor 1

1

0

High-throughput

0.458

High

1231773

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.458

High

1257982

UBP30
Ubiquitin carboxyl-terminal hydrolase 30

1

0

High-throughput

0.458

High

1270599

COX15
Heme A synthase COX15

1

0

High-throughput

0.458

High

1279531

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

0

High-throughput

0.458

High

1308023

T126B
Complex I assembly factor TMEM126B, mitochondrial

1

0

High-throughput

0.458

High

1382103

F162A
Protein FAM162A

1

0

High-throughput

0.458

High

1384173

TM186
Transmembrane protein 186

1

0

High-throughput

0.458

High

1384977

COA7
Cytochrome c oxidase assembly factor 7

1

0

High-throughput

0.458

High

1385323

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

1388576

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.458

High

1388587

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

1388590

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

1388592

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1388593

TIDC1
Complex I assembly factor TIMMDC1, mitochondrial

1

0

High-throughput

0.458

High

1388595

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1388596

MITOS
Mitochondrial potassium channel ATP-binding subunit

1

0

High-throughput

0.458

High

1388597

DJC11
DnaJ homolog subfamily C member 11

1

0

High-throughput

0.458

High

1388604

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.458

High

1388608

NDUAC
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

1

0

High-throughput

0.458

High

1388613

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.458

High

1388616

NDUB9
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9

1

0

High-throughput

0.458

High

1337901

ZNT7
Zinc transporter 7

1

1

High-throughput

0.445

High

1388582

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.445

High

1388586

S2532
Solute carrier family 25 member 32

1

3

High-throughput

0.445

High

669969

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.437

High

880855

NRAM2
Natural resistance-associated macrophage protein 2

1

0

High-throughput

0.426

High

1388611

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.426

High

303269

S22A5
Organic cation/carnitine transporter 2

1

1

High-throughput

0.407

High

869647

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

2

High-throughput

0.407

High

870284

S6A12
Sodium- and chloride-dependent betaine transporter

1

2

High-throughput

0.407

High

1157189

S15A2
Solute carrier family 15 member 2

1

1

High-throughput

0.407

High

1175887

TM241
UDP-N-acetylglucosamine transporter TMEM241

1

1

High-throughput

0.407

High

1280804

S35E3
Solute carrier family 35 member E3

1

1

High-throughput

0.407

High

1388574

SC6A7
Sodium-dependent proline transporter

1

2

High-throughput

0.407

High

1388594

S35C2
Solute carrier family 35 member C2

1

2

High-throughput

0.407

High

746553

IFNA8
Interferon alpha-8

3

0

High-throughput

0.347

High

904236

P2RX1
P2X purinoceptor 1

2

0

High-throughput

0.328

High

1180860

S4A8
Electroneutral sodium bicarbonate exchanger 1

2

0

High-throughput

0.328

High

1194700

GXLT1
Glucoside xylosyltransferase 1

2

0

High-throughput

0.328

High

1228644

NR3L1
Natural cytotoxicity triggering receptor 3 ligand 1

2

0

High-throughput

0.328

High

1239408

IIGP5
Interferon-inducible GTPase 5

2

0

High-throughput

0.328

High

1292575

AMGO3
Amphoterin-induced protein 3

2

0

High-throughput

0.328

High

1388580

CNPD1
Protein CNPPD1

2

0

High-throughput

0.328

High

1388584

SIL1
Nucleotide exchange factor SIL1

2

0

High-throughput

0.328

High

1388601

SCN3B
Sodium channel regulatory subunit beta-3

2

0

High-throughput

0.328

High

1388606

FA8A1
Protein FAM8A1

2

0

High-throughput

0.328

High

1388615

5MP1
eIF5-mimic protein 1

2

0

High-throughput

0.328

High

1383434

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

0

High-throughput

0.313

High

71235

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

219451

S26A4
Pendrin

1

0

High-throughput

0.279

Low

420828

AT1B1
Sodium/potassium-transporting ATPase subunit beta-1

1

0

High-throughput

0.279

Low

688610

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

0

High-throughput

0.279

Low

800310

INGR2
Interferon gamma receptor 2

1

0

High-throughput

0.279

Low

832440

OPRX
Nociceptin receptor

1

0

High-throughput

0.279

Low

868009

GLR
Glucagon receptor

1

0

High-throughput

0.279

Low

1023419

AT11A
Phospholipid-transporting ATPase IH

1

0

High-throughput

0.279

Low

1025893

FANCC
Fanconi anemia group C protein

1

0

High-throughput

0.279

Low

1065993

VAC14
Protein VAC14 homolog

1

0

High-throughput

0.279

Low

1165408

CC142
Coiled-coil domain-containing protein 142

1

0

High-throughput

0.279

Low

1186588

KRA61
Keratin-associated protein 6-1

1

0

High-throughput

0.279

Low

1187127

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.279

Low

1187903

KR197
Keratin-associated protein 19-7

1

0

High-throughput

0.279

Low

1212175

ODAD2
Outer dynein arm-docking complex subunit 2

1

0

High-throughput

0.279

Low

1333589

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.279

Low

1386766

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.279

Low

1388570

SAAL1
Protein SAAL1

1

0

High-throughput

0.279

Low

1388588

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1388602

SC5A4
Probable glucose sensor protein SLC5A4

1

0

High-throughput

0.279

Low

1388605

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1388610

UST
Uronyl 2-sulfotransferase

1

0

High-throughput

0.279

Low

420656

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.269

Low

562629

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.249

Low

592876

CBR1
Carbonyl reductase [NADPH] 1

1

0

High-throughput

0.249

Low

1004955

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1330353

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1360290

SCG3
Secretogranin-3

1

0

High-throughput

0.249

Low

1388578

ERP44
Endoplasmic reticulum resident protein 44

1

0

High-throughput

0.249

Low

1388603

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.249

Low

1388609

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

133560

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.232

Low

339049

GTR10
Solute carrier family 2, facilitated glucose transporter member 10

1

0

High-throughput

0.232

Low

374128

RASN
GTPase NRas

1

0

High-throughput

0.232

Low

1060384

SLC31
Amino acid transporter heavy chain SLC3A1

1

0

High-throughput

0.232

Low

1236267

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.232

Low

1246101

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

1388607

DYH17
Dynein axonemal heavy chain 17

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025