Protein: MD1L1
Mitotic spindle assembly checkpoint protein MAD1 (Mitotic arrest deficient 1-like protein 1) (MAD1-like protein 1) (Mitotic checkpoint MAD1 protein homolog) (HsMAD1) (hMAD1) (Tax-binding protein 181)

Gene: MD1L1, MAD1L1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q9Y6D9

Gene Ontology (top 5):
GO:0000776 - kinetochore
GO:0000922 - spindle pole
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1099835

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

29

5

Small-scale

0.994

High

1491833

MD1L1
Mitotic spindle assembly checkpoint protein MAD1

3

18

Small-scale

0.878

High

482987

TPM1
Tropomyosin alpha-1 chain

8

20

High-throughput

0.757

High

1461369

BAG5
BAG family molecular chaperone regulator 5

8

3

High-throughput

0.753

High

447908

TPM3
Tropomyosin alpha-3 chain

5

19

High-throughput

0.728

High

302683

RNF8
E3 ubiquitin-protein ligase RNF8

4

12

High-throughput

0.698

High

1350756

CCHCR
Coiled-coil alpha-helical rod protein 1

4

19

High-throughput

0.698

High

488273

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

4

0

High-throughput

0.679

High

935663

MFAP1
Microfibrillar-associated protein 1

3

1

High-throughput

0.675

High

1491404

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

3

14

High-throughput

0.675

High

216310

KCAB3
Voltage-gated potassium channel subunit beta-3

3

2

High-throughput

0.667

High

1490479

CLC11
C-type lectin domain family 11 member A

3

6

High-throughput

0.667

High

552894

TPR
Nucleoprotein TPR

3

18

Small-scale

0.665

High

538190

HSP7C
Heat shock cognate 71 kDa protein

3

11

High-throughput

0.662

High

1239993

CAVN1
Caveolae-associated protein 1

3

2

High-throughput

0.662

High

1136767

MD2BP
MAD2L1-binding protein

4

0

Small-scale

0.649

High

1405421

T22D3
TSC22 domain family protein 3

3

0

High-throughput

0.646

High

1121002

TRI29
Tripartite motif-containing protein 29

4

8

High-throughput

0.644

High

302214

NEBL
Nebulette

4

13

High-throughput

0.637

High

1192175

LEGL
Galectin-related protein

3

6

High-throughput

0.616

High

573916

CCNB1
G2/mitotic-specific cyclin-B1

2

1

Small-scale

0.611

High

682125

RBTN1
Rhombotin-1

2

4

High-throughput

0.606

High

1057674

CDK18
Cyclin-dependent kinase 18

2

18

High-throughput

0.606

High

1180050

CCD57
Coiled-coil domain-containing protein 57

2

17

High-throughput

0.606

High

1214393

SYT6
Synaptotagmin-6

2

4

High-throughput

0.606

High

1239762

PPR18
Phostensin

2

13

High-throughput

0.606

High

1347423

LMO3
LIM domain only protein 3

2

4

High-throughput

0.606

High

1348599

LNX1
E3 ubiquitin-protein ligase LNX

2

11

High-throughput

0.606

High

1420321

TSG10
Testis-specific gene 10 protein

2

16

High-throughput

0.606

High

1431366

ATG5
Autophagy protein 5

2

2

High-throughput

0.606

High

1437610

KIF9
Kinesin-like protein KIF9

2

9

High-throughput

0.606

High

1317031

FAM9B
Protein FAM9B

2

1

High-throughput

0.601

High

260662

BRD4
Bromodomain-containing protein 4

2

10

High-throughput

0.584

High

1086949

CDC20
Cell division cycle protein 20 homolog

2

18

Small-scale

0.584

High

353763

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

1158630

CDC37
Hsp90 co-chaperone Cdc37

2

0

High-throughput

0.580

High

1349461

MIEAP
Mitochondria-eating protein

2

0

High-throughput

0.580

High

1370647

GPKOW
G-patch domain and KOW motifs-containing protein

2

0

High-throughput

0.580

High

1392965

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.580

High

1491834

CAN7
Calpain-7

2

0

High-throughput

0.580

High

562772

BMP1
Bone morphogenetic protein 1

2

3

High-throughput

0.574

High

1326710

PTGR3
Prostaglandin reductase 3

2

3

High-throughput

0.574

High

681098

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.573

High

1224722

TSH3
Teashirt homolog 3

1

9

High-throughput

0.573

High

1451885

ZSC32
Zinc finger and SCAN domain-containing protein 32

1

4

High-throughput

0.573

High

1035543

CENPE
Centromere-associated protein E

1

1

Small-scale

0.569

High

714561

PML
Protein PML

1

12

Small-scale

0.561

High

1359472

LMO7
LIM domain only protein 7

1

19

Small-scale

0.561

High

130670

SPT5H
Transcription elongation factor SPT5

1

5

High-throughput

0.560

High

1412954

SYT17
Synaptotagmin-17

2

4

High-throughput

0.553

High

1386310

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.549

High

1462034

SPAT2
Spermatogenesis-associated protein 2

1

0

High-throughput

0.549

High

800199

COIL
Coilin

1

1

High-throughput

0.541

High

900250

FXR1
RNA-binding protein FXR1

1

6

High-throughput

0.541

High

1144518

NONO
Non-POU domain-containing octamer-binding protein

1

12

High-throughput

0.541

High

1490779

NINL
Ninein-like protein

1

19

High-throughput

0.541

High

1490793

AMOL2
Angiomotin-like protein 2

1

17

High-throughput

0.541

High

325508

CCNB2
G2/mitotic-specific cyclin-B2

1

1

High-throughput

0.536

High

668770

APC
Adenomatous polyposis coli protein

1

15

High-throughput

0.536

High

931179

HSP72
Heat shock-related 70 kDa protein 2

1

11

High-throughput

0.536

High

967085

1433G
14-3-3 protein gamma

1

20

High-throughput

0.536

High

1049956

1433F
14-3-3 protein eta

1

20

High-throughput

0.536

High

1110227

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.536

High

1111402

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.536

High

1368229

HDAC2
Histone deacetylase 2

1

20

Small-scale

0.536

High

1404554

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1407025

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

1434865

ASB7
Ankyrin repeat and SOCS box protein 7

1

9

High-throughput

0.536

High

1453814

FOXJ2
Forkhead box protein J2

1

5

High-throughput

0.536

High

1416004

YJU2
Splicing factor YJU2

1

1

High-throughput

0.523

High

1094003

TRAF1
TNF receptor-associated factor 1

1

3

High-throughput

0.515

High

1178925

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1357239

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1414706

DHRS6
Dehydrogenase/reductase SDR family member 6

1

0

High-throughput

0.513

High

508922

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

High-throughput

0.501

High

1107516

BIRC2
Baculoviral IAP repeat-containing protein 2

1

5

Small-scale

0.501

High

1403060

SIN3A
Paired amphipathic helix protein Sin3a

1

1

Small-scale

0.501

High

1397903

PACRG
Parkin coregulated gene protein

1

0

High-throughput

0.493

High

1211473

CF141
Uncharacterized protein C6orf141

1

1

High-throughput

0.489

High

1361190

PIBF1
Progesterone-induced-blocking factor 1

1

2

High-throughput

0.481

High

1459576

GCP4
Gamma-tubulin complex component 4

1

1

High-throughput

0.481

High

129606

MEN1
Menin

1

3

High-throughput

0.479

High

229592

NRDC
Nardilysin

1

2

Small-scale

0.479

High

539859

RALA
Ras-related protein Ral-A

1

19

High-throughput

0.479

High

607281

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

651744

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

13

Small-scale

0.479

High

718671

CDC27
Cell division cycle protein 27 homolog

1

2

Small-scale

0.479

High

831738

CCNF
Cyclin-F

1

5

High-throughput

0.479

High

1097655

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1137215

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

14

High-throughput

0.479

High

1151114

PCH2
Pachytene checkpoint protein 2 homolog

1

11

Small-scale

0.479

High

1219802

MT21C
Protein-lysine methyltransferase METTL21C

1

6

High-throughput

0.479

High

1256310

TRI67
Tripartite motif-containing protein 67

1

18

High-throughput

0.479

High

1340850

COP1
E3 ubiquitin-protein ligase COP1

1

19

High-throughput

0.479

High

1360857

ASB11
Ankyrin repeat and SOCS box protein 11

1

8

High-throughput

0.479

High

1367710

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1380702

FBX32
F-box only protein 32

1

9

High-throughput

0.479

High

1408503

VRK1
Serine/threonine-protein kinase VRK1

1

6

High-throughput

0.479

High

1433823

SENP3
Sentrin-specific protease 3

1

1

Small-scale

0.479

High

1459496

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

1461233

IKZF3
Zinc finger protein Aiolos

1

4

High-throughput

0.479

High

1194602

Q4G0R1
PIBF1 protein

1

2

High-throughput

0.470

High

1218102

Q5VU62
TPM3 protein

1

17

High-throughput

0.470

High

378529

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

1460915

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

High-throughput

0.458

High

136161

PLK4
Serine/threonine-protein kinase PLK4

1

16

High-throughput

0.457

High

475090

VIME
Vimentin

1

20

High-throughput

0.457

High

572301

TRI27
Zinc finger protein RFP

1

9

High-throughput

0.457

High

1415270

KIFC3
Kinesin-like protein KIFC3

1

2

Small-scale

0.457

High

1415624

Q9BVR6
Gamma-tubulin complex component

1

1

High-throughput

0.457

High

485770

RU2A
U2 small nuclear ribonucleoprotein A'

1

11

High-throughput

0.445

High

530682

TAU
Microtubule-associated protein tau

1

12

High-throughput

0.445

High

412904

NTRK1
High affinity nerve growth factor receptor

1

17

High-throughput

0.437

High

1231165

SCAR3
Scavenger receptor class A member 3

1

1

High-throughput

0.437

High

1405473

MNT
Max-binding protein MNT

1

15

Small-scale

0.437

High

339034

PRA12
PRAME family member 12

1

0

High-throughput

0.426

High

1208687

NTCP5
Sodium/bile acid cotransporter 5

1

1

High-throughput

0.407

High

1180527

C19L2
CWF19-like protein 2

3

0

High-throughput

0.352

High

1315015

TEX11
Testis-expressed protein 11

2

0

High-throughput

0.317

High

211213

CMIP4
Ciliary microtubule inner protein 4

2

0

High-throughput

0.316

High

1295139

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1385281

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.316

High

1491386

TCAF1
TRPM8 channel-associated factor 1

2

0

High-throughput

0.316

High

1383593

F131C
Protein FAM131C

1

0

High-throughput

0.282

High

1392204

RUSF1
RUS family member 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025