Protein: BACE2
Beta-secretase 2 (EC 3.4.23.45) (Aspartic-like protease 56 kDa) (Aspartyl protease 1) (ASP1) (Asp 1) (Beta-site amyloid precursor protein cleaving enzyme 2) (Beta-site APP cleaving enzyme 2) (Down region aspartic protease) (DRAP) (Memapsin-1) (Membrane-associated aspartic protease 1) (Theta-secretase)

Gene: BACE2
Organism: Homo sapiens
Interactions: 101
UniProt ID: Q9Y5Z0

Gene Ontology (top 5):
GO:0004190 - aspartic-type endopeptidase activity
GO:0005768 - endosome
GO:0005783 - endoplasmic reticulum
GO:0005794 - Golgi apparatus
GO:0005802 - trans-Golgi network

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

840862

MATK
Megakaryocyte-associated tyrosine-protein kinase

1

1

High-throughput

0.665

High

362428

ABL1
Tyrosine-protein kinase ABL1

1

0

High-throughput

0.656

High

568101

HLAE
HLA class I histocompatibility antigen, alpha chain E

3

0

High-throughput

0.638

High

931471

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

3

0

High-throughput

0.638

High

1450339

CC50A
Cell cycle control protein 50A

3

0

High-throughput

0.638

High

586198

CD1E
T-cell surface glycoprotein CD1e, membrane-associated

2

1

High-throughput

0.628

High

1286972

TM11B
Transmembrane protease serine 11B

2

3

High-throughput

0.628

High

1460040

CLC2D
C-type lectin domain family 2 member D

2

4

High-throughput

0.628

High

1198770

MPPE1
Metallophosphoesterase 1

2

0

High-throughput

0.602

High

1362538

SIA8D
CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase

2

0

High-throughput

0.602

High

1429071

CHST6
Carbohydrate sulfotransferase 6

2

0

High-throughput

0.602

High

139365

UPK2
Uroplakin-2

2

0

High-throughput

0.576

High

71370

F1712
Protein FAM171A2

1

1

High-throughput

0.536

High

437846

HEPS
Serine protease hepsin

1

3

High-throughput

0.536

High

540115

BCR
Breakpoint cluster region protein

1

2

High-throughput

0.536

High

688654

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

5

High-throughput

0.536

High

1218263

F1711
Protein FAM171A1

1

1

High-throughput

0.536

High

1219974

ZDH20
Palmitoyltransferase ZDHHC20

1

1

High-throughput

0.536

High

1331059

DDX51
ATP-dependent RNA helicase DDX51

1

1

High-throughput

0.536

High

1363171

CLC2B
C-type lectin domain family 2 member B

1

5

High-throughput

0.536

High

1382100

T106A
Transmembrane protein 106A

1

2

High-throughput

0.536

High

1392318

ZDH12
Palmitoyltransferase ZDHHC12

1

2

High-throughput

0.536

High

1405324

PKP4
Plakophilin-4

1

1

High-throughput

0.536

High

1416352

PAPOG
Poly(A) polymerase gamma

1

1

High-throughput

0.536

High

1454387

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.536

High

1491777

ST14
Suppressor of tumorigenicity 14 protein

1

3

High-throughput

0.536

High

1143612

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.518

High

286744

STX11
Syntaxin-11

1

1

High-throughput

0.515

High

423547

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

1307870

TMTC1
Protein O-mannosyl-transferase TMTC1

1

1

High-throughput

0.515

High

1362022

RFFL
E3 ubiquitin-protein ligase rififylin

1

2

High-throughput

0.515

High

136020

P3C2A
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha

1

0

High-throughput

0.513

High

248640

FADS1
Acyl-CoA

1

0

High-throughput

0.513

High

755387

ABCD1
ATP-binding cassette sub-family D member 1

1

0

High-throughput

0.513

High

774025

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.513

High

878116

AGRE5
Adhesion G protein-coupled receptor E5

1

0

High-throughput

0.513

High

1009174

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

0

High-throughput

0.513

High

1159924

OCLN
Occludin

1

0

High-throughput

0.513

High

1206181

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.513

High

1270833

RUFY3
Protein RUFY3

1

0

High-throughput

0.513

High

1277264

POGZ
Pogo transposable element with ZNF domain

1

0

High-throughput

0.513

High

1331212

F241A
Uncharacterized protein FAM241A

1

0

High-throughput

0.513

High

1335167

LEMD2
LEM domain-containing protein 2

1

0

High-throughput

0.513

High

1388955

ARSG
Arylsulfatase G

1

0

High-throughput

0.513

High

1413170

NFIP1
NEDD4 family-interacting protein 1

1

0

High-throughput

0.513

High

1418694

HYCCI
Hyccin

1

0

High-throughput

0.513

High

1454335

TEN3
Teneurin-3

1

0

High-throughput

0.513

High

1458419

S53A1
Solute carrier family 53 member 1

1

0

High-throughput

0.513

High

1461572

KDIS
Kinase D-interacting substrate of 220 kDa

1

0

High-throughput

0.513

High

1491638

PCDG9
Protocadherin gamma-A9

1

0

High-throughput

0.513

High

1460809

GGA2
ADP-ribosylation factor-binding protein GGA2

1

5

Small-scale

0.501

High

1460816

GGA1
ADP-ribosylation factor-binding protein GGA1

1

5

Small-scale

0.501

High

475733

K1C19
Keratin, type I cytoskeletal 19

1

0

High-throughput

0.493

High

1108820

ASAH1
Acid ceramidase

1

0

High-throughput

0.493

High

1294038

CTSRD
Cation channel sperm-associated auxiliary subunit delta

1

0

High-throughput

0.493

High

1365712

LAR4B
La-related protein 4B

1

0

High-throughput

0.493

High

1417676

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

0

High-throughput

0.493

High

1445861

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

0

High-throughput

0.493

High

324067

CSTN1
Calsyntenin-1

1

3

High-throughput

0.489

High

568027

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.489

High

899772

PAPOA
Poly(A) polymerase alpha

1

1

High-throughput

0.489

High

996905

TBA1B
Tubulin alpha-1B chain

1

3

High-throughput

0.489

High

997214

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.489

High

1215450

DEP1A
DEP domain-containing protein 1A

1

1

High-throughput

0.489

High

1338134

NAV1
Neuron navigator 1

1

1

High-throughput

0.489

High

1357452

DEP1B
DEP domain-containing protein 1B

1

2

High-throughput

0.489

High

1410650

TBA1C
Tubulin alpha-1C chain

1

3

High-throughput

0.489

High

1460740

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.489

High

1462578

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.489

High

219019

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.479

High

329040

RTN3
Reticulon-3

1

2

Small-scale

0.479

High

1231712

LEG9C
Galectin-9C

1

1

High-throughput

0.470

High

178454

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

1312631

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

171039

CLGN
Calmegin

1

4

High-throughput

0.445

High

638267

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

High-throughput

0.445

High

1324773

S35F6
Solute carrier family 35 member F6

1

1

High-throughput

0.445

High

534553

IAPP
Islet amyloid polypeptide

1

1

Small-scale

0.407

High

1292603

IFNE
Interferon epsilon

2

0

High-throughput

0.328

High

1392512

TECT2
Tectonic-2

2

0

High-throughput

0.328

High

473229

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.282

High

1042719

KIME
Mevalonate kinase

1

0

High-throughput

0.279

Low

1206590

PRC2B
Protein PRRC2B

1

0

High-throughput

0.279

Low

1322496

TTC5
Tetratricopeptide repeat protein 5

1

0

High-throughput

0.279

Low

1341178

WDR36
WD repeat-containing protein 36

1

0

High-throughput

0.279

Low

1346574

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.279

Low

1348148

PUM2
Pumilio homolog 2

1

0

High-throughput

0.279

Low

1392648

CENPN
Centromere protein N

1

0

High-throughput

0.279

Low

1395228

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

0

High-throughput

0.279

Low

1395268

LMBL3
Lethal(3)malignant brain tumor-like protein 3

1

0

High-throughput

0.279

Low

1400714

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.279

Low

1448439

PYRG2
CTP synthase 2

1

0

High-throughput

0.279

Low

447906

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.268

Low

944772

KLF3
Krueppel-like factor 3

1

0

High-throughput

0.268

Low

1133200

LASP1
LIM and SH3 domain protein 1

1

0

High-throughput

0.268

Low

1351655

TCP1L
T-complex protein 10A homolog 1

1

0

High-throughput

0.268

Low

1412279

RHNO1
RAD9, HUS1, RAD1-interacting nuclear orphan protein 1

1

0

High-throughput

0.268

Low

1417385

TEX12
Testis-expressed protein 12

1

0

High-throughput

0.268

Low

1491783

DUS10
Dual specificity protein phosphatase 10

1

0

High-throughput

0.268

Low

386410

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

Small-scale

0.249

Low

1340588

MFSD8
Major facilitator superfamily domain-containing protein 8

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025