Protein: SRFB1
Serum response factor-binding protein 1 (SRF-dependent transcription regulation-associated protein) (p49/STRAP)

Gene: SRFB1, SRFBP1
Organism: Homo sapiens
Interactions: 107
UniProt ID: Q8NEF9

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0030490 - maturation of SSU-rRNA
GO:0030686 - 90S preribosome
GO:0048471 - perinuclear region of cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1098258

DDX10
Probable ATP-dependent RNA helicase DDX10

4

1

High-throughput

0.691

High

643938

FBRL
rRNA 2'-O-methyltransferase fibrillarin

5

0

High-throughput

0.684

High

1118928

BYST
Bystin

3

0

High-throughput

0.638

High

372612

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

396541

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

502439

H2A1
Histone H2A type 1

1

1

High-throughput

0.536

High

1307280

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.536

High

1309665

ARHGJ
Rho guanine nucleotide exchange factor 19

2

2

High-throughput

0.521

High

134095

IPO5
Importin-5

1

0

High-throughput

0.513

High

191715

MAGB2
Melanoma-associated antigen B2

1

0

High-throughput

0.513

High

326745

DUS14
Dual specificity protein phosphatase 14

1

0

High-throughput

0.513

High

658285

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.513

High

969983

RS16
Small ribosomal subunit protein uS9

1

0

High-throughput

0.513

High

1065309

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

185864

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

549341

SRF
Serum response factor

1

0

Small-scale

0.480

High

254395

CC14B
Dual specificity protein phosphatase CDC14B

1

2

High-throughput

0.479

High

406405

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

487547

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

998561

H31
Histone H3.1

1

1

High-throughput

0.479

High

1215722

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1337419

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

141008

NOP56
Nucleolar protein 56

1

0

High-throughput

0.458

High

170238

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

191004

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

242325

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

401167

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

558276

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

697185

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

799990

COIL
Coilin

1

0

High-throughput

0.458

High

979072

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

980010

H4
Histone H4

1

0

High-throughput

0.458

High

980937

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

982739

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

984857

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1097436

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

1276501

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1290597

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1313271

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1337407

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

0

High-throughput

0.458

High

1337413

DDX23
Probable ATP-dependent RNA helicase DDX23

1

0

High-throughput

0.458

High

1337414

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

1

0

High-throughput

0.458

High

1337429

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1337432

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1337439

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1337441

DDX49
Probable ATP-dependent RNA helicase DDX49

1

0

High-throughput

0.458

High

951763

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

High-throughput

0.445

High

1034597

AK17A
A-kinase anchor protein 17A

1

2

High-throughput

0.445

High

1214647

RBM26
RNA-binding protein 26

1

1

High-throughput

0.445

High

1216230

H37
Histone H3-7

1

1

High-throughput

0.445

High

1270750

DDX46
Probable ATP-dependent RNA helicase DDX46

1

1

High-throughput

0.445

High

1328337

ZC3H8
Zinc finger CCCH domain-containing protein 8

1

1

High-throughput

0.445

High

1337405

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

1

High-throughput

0.445

High

1337410

YTDC1
YTH domain-containing protein 1

1

1

High-throughput

0.445

High

1337411

SCAFB
Protein SCAF11

1

2

High-throughput

0.445

High

1337418

SFR19
Splicing factor, arginine/serine-rich 19

1

1

High-throughput

0.445

High

1337427

H2AW
Core histone macro-H2A.2

1

2

High-throughput

0.445

High

1337430

RBM27
RNA-binding protein 27

1

3

High-throughput

0.445

High

1337431

ZO2
Tight junction protein 2

1

1

High-throughput

0.445

High

1337437

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.445

High

1337426

ITSN2
Intersectin-2

1

1

High-throughput

0.437

High

182331

WDR46
WD repeat-containing protein 46

1

0

High-throughput

0.426

High

649372

H1T
Histone H1t

1

0

High-throughput

0.426

High

860844

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.426

High

1004368

NOP14
Nucleolar protein 14

1

0

High-throughput

0.426

High

1136470

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.426

High

1141395

WDR43
WD repeat-containing protein 43

1

0

High-throughput

0.426

High

1179330

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.426

High

1208782

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.426

High

1217824

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.426

High

1226781

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

0

High-throughput

0.426

High

1272105

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.426

High

1279867

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

0

High-throughput

0.426

High

1309688

WDR75
WD repeat-containing protein 75

1

0

High-throughput

0.426

High

1336738

RB15B
Putative RNA-binding protein 15B

1

0

High-throughput

0.426

High

1337402

SNIP1
Smad nuclear-interacting protein 1

1

0

High-throughput

0.426

High

1337403

ZCRB1
Zinc finger CCHC-type and RNA-binding motif-containing protein 1

1

0

High-throughput

0.426

High

1337409

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.426

High

1337412

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.426

High

1337417

YTDC2
3'-5' RNA helicase YTHDC2

1

0

High-throughput

0.426

High

1337422

IMP3
U3 small nucleolar ribonucleoprotein protein IMP3

1

0

High-throughput

0.426

High

1337425

CDK12
Cyclin-dependent kinase 12

1

0

High-throughput

0.426

High

1337434

ZN346
Zinc finger protein 346

1

0

High-throughput

0.426

High

1337435

ABT1
Activator of basal transcription 1

1

0

High-throughput

0.426

High

1337436

SCAF8
SR-related and CTD-associated factor 8

1

0

High-throughput

0.426

High

1337438

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.426

High

64406

A6H8W8
Intersectin 2

1

1

High-throughput

0.407

High

1058887

ZO1
Tight junction protein 1

1

1

High-throughput

0.407

High

1337406

FBXW5
F-box/WD repeat-containing protein 5

4

0

High-throughput

0.360

High

1337428

RHG23
Rho GTPase-activating protein 23

2

0

High-throughput

0.298

High

657269

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

902391

PLCD1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1

1

0

High-throughput

0.279

Low

1098645

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

1337404

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

1337420

RAB18
Ras-related protein Rab-18

1

0

High-throughput

0.279

Low

1337440

SPCS1
Signal peptidase complex subunit 1

1

0

High-throughput

0.279

Low

1337424

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.269

Low

1337415

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.249

Low

1337421

VPS45
Vacuolar protein sorting-associated protein 45

1

0

High-throughput

0.249

Low

1337433

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.249

Low

334443

SYFM
Phenylalanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.232

Low

593857

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

0

High-throughput

0.232

Low

948881

CD81
CD81 antigen

1

0

Small-scale

0.232

Low

1337401

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low

1337408

RN166
E3 ubiquitin-protein ligase RNF166

1

0

High-throughput

0.232

Low

1337416

OSBL3
Oxysterol-binding protein-related protein 3

1

0

High-throughput

0.232

Low

1337423

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025