Protein: TF2AA
Transcription initiation factor IIA subunit 1 (General transcription factor IIA subunit 1) (TFIIAL) (Transcription initiation factor TFIIA 42 kDa subunit) (TFIIA-42) [Cleaved into: Transcription initiation factor IIA alpha chain (TFIIA p35 subunit); Transcription initiation factor IIA beta chain (TFIIA p19 subunit)]

Gene: TF2AA, GTF2A1
Organism: Homo sapiens
Interactions: 67
UniProt ID: P52655

Gene Ontology (top 5):
GO:0000979 - RNA polymerase II core promoter sequence-specific DNA binding
GO:0001091 - RNA polymerase II general transcription initiation factor binding
GO:0003677 - DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

628732

TBP
TATA-box-binding protein

14

10

Small-scale

0.983

High

913234

T2AG
Transcription initiation factor IIA subunit 2

11

5

Small-scale

0.978

High

913238

TBPL1
TATA box-binding protein-like 1

9

10

Small-scale

0.971

High

659665

NFYA
Nuclear transcription factor Y subunit alpha

4

0

High-throughput

0.668

High

913260

TAF4B
Transcription initiation factor TFIID subunit 4B

1

2

Small-scale

0.647

High

187320

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

0

High-throughput

0.638

High

130721

TAF4
Transcription initiation factor TFIID subunit 4

1

2

High-throughput

0.618

High

913252

TBPL2
TATA box-binding protein-like 2

1

10

High-throughput

0.618

High

913245

SP4
Transcription factor Sp4

2

2

High-throughput

0.606

High

913235

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

2

0

High-throughput

0.602

High

913237

PRS10
26S proteasome regulatory subunit 10B

2

0

High-throughput

0.580

High

913261

BIRC7
Baculoviral IAP repeat-containing protein 7

2

0

High-throughput

0.580

High

708939

T2EB
Transcription initiation factor IIE subunit beta

2

0

Small-scale

0.577

High

593061

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.518

High

913247

MK07
Mitogen-activated protein kinase 7

1

0

High-throughput

0.513

High

481171

HMGB1
High mobility group protein B1

1

1

Small-scale

0.501

High

374487

RASH
GTPase HRas

1

0

High-throughput

0.493

High

634915

BCL3
B-cell lymphoma 3 protein

1

0

Small-scale

0.480

High

639692

TAF1
Transcription initiation factor TFIID subunit 1

1

0

Small-scale

0.480

High

708883

T2EA
General transcription factor IIE subunit 1

1

0

Small-scale

0.480

High

770359

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.480

High

913248

NCOA6
Nuclear receptor coactivator 6

1

0

Small-scale

0.480

High

341539

EYA4
Protein phosphatase EYA4

1

1

High-throughput

0.479

High

464884

SP1
Transcription factor Sp1

1

2

Small-scale

0.479

High

606476

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

913244

EWS
RNA-binding protein EWS

1

1

High-throughput

0.479

High

913242

PR20D
Proline-rich protein 20D

1

1

High-throughput

0.470

High

63985

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

136855

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

298329

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

371531

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

378481

IL1A
Interleukin-1 alpha

1

0

Small-scale

0.458

High

385584

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

485009

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

557975

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

588265

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

694991

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

767758

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

791201

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

891997

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.458

High

913236

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

913239

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

913240

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

913249

TAF5
Transcription initiation factor TFIID subunit 5

1

0

High-throughput

0.458

High

913250

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.458

High

913253

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

913254

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

913256

MKX
Homeobox protein Mohawk

1

0

Small-scale

0.458

High

913259

GCN1
Stalled ribosome sensor GCN1

1

0

High-throughput

0.458

High

913264

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

1

0

High-throughput

0.458

High

913265

CUED2
CUE domain-containing protein 2

1

0

High-throughput

0.458

High

913266

KDM5B
Lysine-specific demethylase 5B

1

0

Small-scale

0.458

High

913267

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

913243

PR20A
Proline-rich protein 20A

1

1

High-throughput

0.439

High

913255

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

Small-scale

0.426

High

913258

PTCD2
Pentatricopeptide repeat-containing protein 2, mitochondrial

3

0

High-throughput

0.347

High

913263

CYBC1
Cytochrome b-245 chaperone 1

3

0

High-throughput

0.347

High

913241

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

47311

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

282570

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.268

Low

650096

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

913246

Q0VDC6
peptidylprolyl isomerase

1

0

High-throughput

0.268

Low

516750

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low

801236

HSPA9
Stress-70 protein, mitochondrial

1

0

High-throughput

0.249

Low

913251

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.249

Low

913262

DOCK7
Dedicator of cytokinesis protein 7

1

0

High-throughput

0.249

Low

913257

NEUFC
Neuferricin

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025