Protein: SRP68
Signal recognition particle subunit SRP68 (Signal recognition particle 68 kDa protein homolog)

Gene: SRP68
Organism: Saccharomyces cerevisiae S288C
Interactions: 63
UniProt ID: P38687

Gene Ontology (top 5):
GO:0005047 - signal recognition particle binding
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0005786 - signal recognition particle, endoplasmic reticulum targeting
GO:0006614 - SRP-dependent cotranslational protein targeting to membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

631913

SRP54
Signal recognition particle subunit SRP54

3

2

High-throughput

0.855

High

713224

SEC65
Signal recognition particle subunit SEC65

5

1

Small-scale

0.709

High

801716

SRP72
Signal recognition particle subunit SRP72

5

2

Small-scale

0.706

High

751956

LHP1
La protein homolog

3

3

High-throughput

0.667

High

801718

SRP14
Signal recognition particle subunit SRP14

4

0

High-throughput

0.661

High

734819

SRP21
Signal recognition particle subunit SRP21

2

0

High-throughput

0.576

High

721903

XPO1
Exportin-1

1

4

High-throughput

0.536

High

801728

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

801730

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

2

High-throughput

0.536

High

801741

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.536

High

432562

RL7A
Large ribosomal subunit protein uL30A

1

2

High-throughput

0.479

High

435060

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

435935

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

512413

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.479

High

569995

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

666445

DBP2
ATP-dependent RNA helicase DBP2

1

1

High-throughput

0.479

High

682265

SPB4
ATP-dependent rRNA helicase SPB4

1

5

High-throughput

0.479

High

684705

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

778299

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

792018

GBLP
Small ribosomal subunit protein RACK1

1

2

High-throughput

0.479

High

801726

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

801732

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.479

High

149733

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

558698

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

670657

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

709732

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

745722

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

801717

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

801738

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

394512

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

453573

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.445

High

523813

HSP71
Heat shock protein SSA1

1

2

High-throughput

0.445

High

526586

HSP72
Heat shock protein SSA2

1

2

High-throughput

0.445

High

544722

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

741494

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.445

High

801721

IMB4
Importin subunit beta-4

1

2

High-throughput

0.445

High

801722

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

801729

SEN1
Helicase SEN1

1

1

Small-scale

0.445

High

410102

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

512981

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

747334

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

801723

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.437

High

801740

RLM1
Transcription factor RLM1

1

1

High-throughput

0.437

High

671629

SCJ1
DnaJ-related protein SCJ1

1

0

High-throughput

0.426

High

752209

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.426

High

801724

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

801731

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.417

High

755085

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.407

High

801719

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.407

High

801735

RPN9
26S proteasome regulatory subunit RPN9

1

1

High-throughput

0.407

High

801737

CDC73
Cell division control protein 73

1

0

High-throughput

0.269

Low

677845

RDS1
Regulator of drug sensitivity 1

1

0

High-throughput

0.265

Low

679634

CDC48
Cell division control protein 48

1

0

High-throughput

0.249

Low

706984

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

735492

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

0

High-throughput

0.249

Low

748373

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

801720

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

801727

UBC9
SUMO-conjugating enzyme UBC9

1

0

High-throughput

0.249

Low

801734

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

801736

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

801739

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

801725

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

0

High-throughput

0.232

Low

801733

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025