Protein: CDC73
Cell division control protein 73 (RNA polymerase-associated protein CDC73)

Gene: CDC73
Organism: Saccharomyces cerevisiae S288C
Interactions: 115
UniProt ID: Q06697

Gene Ontology (top 5):
GO:0000791 - euchromatin
GO:0000993 - RNA polymerase II complex binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0006362 - transcription elongation by RNA polymerase I

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1018331

CTR9
RNA polymerase-associated protein CTR9

17

6

Small-scale

0.763

High

798622

PAF1
RNA polymerase II-associated protein 1

16

3

Small-scale

0.762

High

916887

RTF1
RNA polymerase-associated protein RTF1

14

1

Small-scale

0.761

High

800275

LEO1
RNA polymerase-associated protein LEO1

12

3

Small-scale

0.759

High

402127

RPB1
DNA-directed RNA polymerase II subunit RPB1

6

2

Small-scale

0.737

High

739790

SPT16
FACT complex subunit SPT16

9

0

Small-scale

0.719

High

1056542

CDC73
Cell division control protein 73

2

0

Small-scale

0.718

High

470599

RPB2
DNA-directed RNA polymerase II subunit RPB2

4

1

Small-scale

0.692

High

594589

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

1

Small-scale

0.680

High

694654

SPT5
Transcription elongation factor SPT5

3

1

Small-scale

0.670

High

708302

TF2B
Transcription initiation factor IIB

3

1

Small-scale

0.665

High

806955

RPB11
DNA-directed RNA polymerase II subunit RPB11

3

0

Small-scale

0.623

High

1046942

POB3
FACT complex subunit POB3

4

1

Small-scale

0.623

High

586032

CSK21
Casein kinase II subunit alpha

2

1

High-throughput

0.621

High

623022

CSK22
Casein kinase II subunit alpha'

2

1

High-throughput

0.621

High

624946

MED15
Mediator of RNA polymerase II transcription subunit 15

3

0

Small-scale

0.614

High

580134

HSC82
ATP-dependent molecular chaperone HSC82

3

4

High-throughput

0.604

High

525288

HSP71
Heat shock protein SSA1

2

4

High-throughput

0.601

High

671166

SIS1
Protein SIS1

2

1

High-throughput

0.584

High

925086

APJ1
J domain-containing protein APJ1

2

1

High-throughput

0.571

High

740815

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.559

High

836558

T2FB
Transcription initiation factor IIF subunit beta

2

0

Small-scale

0.547

High

763380

TAF14
Transcription initiation factor TFIID subunit 14

2

2

Small-scale

0.543

High

661198

SPT6
Transcription elongation factor SPT6

1

0

Small-scale

0.537

High

527796

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.536

High

546440

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.536

High

727346

HS104
Heat shock protein 104

1

1

High-throughput

0.536

High

1042380

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.515

High

454492

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

1027285

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

Small-scale

0.506

High

438549

UBC2
Ubiquitin-conjugating enzyme E2 2

1

3

Small-scale

0.501

High

744349

CHD1
Chromo domain-containing protein 1

1

2

Small-scale

0.501

High

963747

H3
Histone H3

1

2

Small-scale

0.501

High

809421

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

866292

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.493

High

921077

SPC98
Spindle pole body component SPC98

1

0

High-throughput

0.493

High

1039052

IMA1
Importin subunit alpha

1

0

High-throughput

0.493

High

1056548

RUP1
UBA domain-containing protein RUP1

1

0

High-throughput

0.493

High

752786

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.489

High

807791

CSK2C
Casein kinase II subunit beta'

1

1

High-throughput

0.489

High

851024

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.489

High

810670

SSN3
Meiotic mRNA stability protein kinase SSN3

1

2

Small-scale

0.481

High

382373

H4
Histone H4

1

1

High-throughput

0.479

High

436529

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

3

High-throughput

0.479

High

647235

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

680096

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

699975

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

1

High-throughput

0.479

High

708790

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.479

High

757350

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

1

High-throughput

0.479

High

793457

ATR
Serine/threonine-protein kinase MEC1

1

2

Small-scale

0.479

High

805578

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

3

Small-scale

0.479

High

823198

RAD26
DNA repair and recombination protein RAD26

1

2

Small-scale

0.479

High

917328

INO80
Chromatin-remodeling ATPase INO80

1

2

Small-scale

0.479

High

1051615

HRQ1
ATP-dependent helicase HRQ1

1

1

Small-scale

0.479

High

737500

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

1

High-throughput

0.470

High

561539

TBP
TATA-box-binding protein

1

0

Small-scale

0.460

High

598444

TUP1
General transcriptional corepressor TUP1

1

0

Small-scale

0.460

High

364765

CDK1
Cyclin-dependent kinase 1

1

0

High-throughput

0.458

High

605929

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.458

High

632115

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

632217

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.458

High

632294

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

632376

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

645090

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.458

High

726246

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

1

0

Small-scale

0.458

High

735185

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

748066

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

818394

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

0

High-throughput

0.458

High

823734

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.458

High

826875

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

836539

T2FA
Transcription initiation factor IIF subunit alpha

1

0

High-throughput

0.458

High

874269

CLA4
Serine/threonine-protein kinase CLA4

1

0

Small-scale

0.458

High

918379

TAL2
Transaldolase NQM1

1

0

High-throughput

0.458

High

924031

ELOA1
Elongin-A

1

0

Small-scale

0.458

High

1054347

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

1

0

Small-scale

0.458

High

1054850

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

1056545

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.458

High

1056546

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

1056547

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

567732

MSI1
Histone-binding protein MSI1

1

1

High-throughput

0.457

High

393403

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.445

High

481778

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.445

High

742495

HSP7F
Heat shock protein homolog SSE1

1

6

High-throughput

0.445

High

804492

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

811413

CAJ1
Protein CAJ1

1

1

High-throughput

0.445

High

912456

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.445

High

1056544

RBX1
RING-box protein HRT1

1

0

High-throughput

0.438

High

1046050

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

1025186

SEN1
Helicase SEN1

1

0

Small-scale

0.426

High

1035127

UBC7
Ubiquitin-conjugating enzyme E2 7

1

3

High-throughput

0.417

High

386875

TBB
Tubulin beta chain

1

1

High-throughput

0.407

High

453816

PYR1
Multifunctional protein URA2

1

1

High-throughput

0.407

High

510849

HSP77
Import motor subunit, mitochondrial

1

5

High-throughput

0.407

High

554053

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.407

High

810905

TCPG
T-complex protein 1 subunit gamma

1

4

High-throughput

0.407

High

816427

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.407

High

924065

JJJ1
J protein JJJ1

1

1

High-throughput

0.407

High

932301

ZDS2
Protein ZDS2

1

1

High-throughput

0.407

High

1056426

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

1

High-throughput

0.407

High

598366

ATE1
Arginyl-tRNA--protein transferase 1

1

0

High-throughput

0.269

Low

801737

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.269

Low

1056551

FOLD
Dihydrofolate synthetase

1

0

High-throughput

0.269

Low

677583

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

790433

GLY1
Low specificity L-threonine aldolase

1

0

High-throughput

0.249

Low

792579

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.249

Low

828323

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.249

Low

835931

VMA21
Vacuolar ATPase assembly integral membrane protein VMA21

1

0

High-throughput

0.249

Low

844630

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

1056543

CRT10
Protein CRT10

1

0

Small-scale

0.249

Low

577222

SEC63
Protein translocation protein SEC63

1

0

High-throughput

0.232

Low

816751

PFD2
Prefoldin subunit 2

1

0

High-throughput

0.232

Low

836916

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

1056549

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low

1056550

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025