Protein: COX3
Cytochrome c oxidase subunit 3 (EC 7.1.1.9) (Cytochrome c oxidase polypeptide III)

Gene: COX3, MT-CO3
Organism: Homo sapiens
Interactions: 46
UniProt ID: P00414

Gene Ontology (top 5):
GO:0004129 - cytochrome-c oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006123 - mitochondrial electron transport, cytochrome c to oxygen
GO:0008535 - respiratory chain complex IV assembly

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

360708

CX6A1
Cytochrome c oxidase subunit 6A1, mitochondrial

1

1

High-throughput

0.691

High

360711

CX7A1
Cytochrome c oxidase subunit 7A1, mitochondrial

1

0

High-throughput

0.656

High

360709

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.513

High

360714

SYUA
Alpha-synuclein

1

0

Small-scale

0.484

High

360721

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.481

High

240423

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

360732

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

Small-scale

0.458

High

360693

ANT3
Antithrombin-III

1

2

Small-scale

0.437

High

360694

A1AT
Alpha-1-antitrypsin

1

2

Small-scale

0.437

High

360695

AACT
Alpha-1-antichymotrypsin

1

2

Small-scale

0.437

High

360696

ANGT
Angiotensinogen

1

3

Small-scale

0.437

High

360697

A2MG
Alpha-2-macroglobulin

1

3

Small-scale

0.437

High

360698

CO3
Complement C3

1

3

Small-scale

0.437

High

360699

CO5
Complement C5

1

3

Small-scale

0.437

High

360701

APOA1
Apolipoprotein A-I

1

1

Small-scale

0.437

High

360702

APOE
Apolipoprotein E

1

1

Small-scale

0.437

High

360710

PZP
Pregnancy zone protein

1

3

Small-scale

0.437

High

360713

PEDF
Pigment epithelium-derived factor

1

3

Small-scale

0.437

High

360718

B2MG
Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]

1

1

Small-scale

0.437

High

360700

RASK
GTPase KRas

1

0

High-throughput

0.282

High

165882

FFAR1
Free fatty acid receptor 1

1

0

High-throughput

0.279

Low

360728

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.279

Low

360722

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.265

Low

360716

DNLI4
DNA ligase 4

1

0

High-throughput

0.251

Low

360719

RAC1
Ras-related C3 botulinum toxin substrate 1

1

0

High-throughput

0.251

Low

105051

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

222621

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.249

Low

227292

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

360692

CFAB
Complement factor B

1

0

Small-scale

0.249

Low

360703

VTDB
Vitamin D-binding protein

1

0

Small-scale

0.249

Low

360704

TRFE
Serotransferrin

1

0

Small-scale

0.249

Low

360705

A1BG
Alpha-1B-glycoprotein

1

0

Small-scale

0.249

Low

360706

GELS
Gelsolin

1

0

Small-scale

0.249

Low

360712

ZA2G
Zinc-alpha-2-glycoprotein

1

0

Small-scale

0.249

Low

360717

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.249

Low

360720

ENPP2
Autotaxin

1

0

Small-scale

0.249

Low

360723

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

360727

CNTRL
Centriolin

1

0

High-throughput

0.249

Low

360730

TRIM6
Tripartite motif-containing protein 6

1

0

Small-scale

0.249

Low

360707

ELNE
Neutrophil elastase

1

0

Small-scale

0.238

Low

360729

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

Small-scale

0.238

Low

360715

HD
Huntingtin

1

0

High-throughput

0.232

Low

360724

NPAL3
NIPA-like protein 3

1

0

High-throughput

0.232

Low

360725

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

0

High-throughput

0.232

Low

360726

S35E3
Solute carrier family 35 member E3

1

0

High-throughput

0.232

Low

360731

S35A3
UDP-N-acetylglucosamine transporter

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025