Protein: APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)

Gene: APEX2
Organism: Homo sapiens
Interactions: 34
UniProt ID: Q9UBZ4

Gene Ontology (top 5):
GO:0001650 - fibrillar center
GO:0003677 - DNA binding
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 - endonuclease activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1310803

CUL9
Cullin-9

3

1

High-throughput

0.667

High

1363102

DDB2
DNA damage-binding protein 2

2

1

High-throughput

0.628

High

1388762

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

2

High-throughput

0.628

High

551315

PCNA
Proliferating cell nuclear antigen

2

3

Small-scale

0.624

High

1224716

TSH3
Teashirt homolog 3

2

1

High-throughput

0.606

High

1093734

MKRN3
E3 ubiquitin-protein ligase makorin-3

2

0

High-throughput

0.580

High

1099802

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

2

0

High-throughput

0.576

High

323591

TRI37
E3 ubiquitin-protein ligase TRIM37

1

1

High-throughput

0.541

High

1090957

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.541

High

1095833

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

2

High-throughput

0.541

High

1388873

HOOK2
Protein Hook homolog 2

1

1

High-throughput

0.541

High

1209760

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

3

High-throughput

0.536

High

1154607

CC85B
Coiled-coil domain-containing protein 85B

1

0

High-throughput

0.518

High

920520

DAPK1
Death-associated protein kinase 1

1

0

High-throughput

0.513

High

682643

S100P
Protein S100-P

1

0

High-throughput

0.513

High

1429670

COMD4
COMM domain-containing protein 4

1

0

High-throughput

0.513

High

423387

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1458898

NINL
Ninein-like protein

1

1

High-throughput

0.494

High

1458899

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

2

High-throughput

0.489

High

1135152

CUL7
Cullin-7

1

1

High-throughput

0.489

High

508770

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

1098855

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

Small-scale

0.480

High

1400046

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

0

High-throughput

0.480

High

462004

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

761912

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.479

High

159902

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

1338416

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1458897

XPO7
Exportin-7

1

0

High-throughput

0.458

High

1407281

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

3

0

High-throughput

0.346

High

1436843

WDR54
WD repeat-containing protein 54

2

0

High-throughput

0.328

High

1439703

RETN
Resistin

2

0

High-throughput

0.328

High

351617

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

0

High-throughput

0.282

High

1180705

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

1

0

High-throughput

0.279

Low

283383

ERLN1
Erlin-1

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025