Protein: SPY4
Protein sprouty homolog 4 (Spry-4)

Gene: SPY4, SPRY4
Organism: Homo sapiens
Interactions: 108
UniProt ID: Q9C004

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005925 - focal adhesion
GO:0032587 - ruffle membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350521

RASK
GTPase KRas

3

9

High-throughput

0.640

High

1075284

TESK1
Dual specificity testis-specific protein kinase 1

2

6

Small-scale

0.631

High

1017521

PO4F2
POU domain, class 4, transcription factor 2

2

2

High-throughput

0.606

High

1050771

FHL2
Four and a half LIM domains protein 2

2

9

High-throughput

0.606

High

1154142

KR511
Keratin-associated protein 5-11

2

20

High-throughput

0.606

High

374837

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

4

Small-scale

0.601

High

942442

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

2

0

High-throughput

0.595

High

610503

CBL
E3 ubiquitin-protein ligase CBL

1

7

Small-scale

0.589

High

208192

SPY2
Protein sprouty homolog 2

2

15

Small-scale

0.584

High

348907

RASN
GTPase NRas

2

10

High-throughput

0.584

High

349623

RASH
GTPase HRas

2

8

High-throughput

0.584

High

507221

LAMP1
Lysosome-associated membrane glycoprotein 1

2

3

High-throughput

0.584

High

914338

RB11A
Ras-related protein Rab-11A

2

3

High-throughput

0.584

High

903846

NTF2
Nuclear transport factor 2

2

0

High-throughput

0.580

High

1144618

TENS2
Tensin-2

2

1

High-throughput

0.576

High

1251913

RIN3
Ras and Rab interactor 3

2

1

High-throughput

0.576

High

197622

ADA12
Disintegrin and metalloproteinase domain-containing protein 12

2

1

High-throughput

0.553

High

308134

VENTX
Homeobox protein VENTX

2

11

High-throughput

0.553

High

328051

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

5

High-throughput

0.553

High

686528

OTX1
Homeobox protein OTX1

2

2

High-throughput

0.553

High

830014

HXA1
Homeobox protein Hox-A1

2

16

High-throughput

0.553

High

973639

CREB5
Cyclic AMP-responsive element-binding protein 5

2

4

High-throughput

0.553

High

1103541

KLH38
Kelch-like protein 38

2

2

High-throughput

0.553

High

527775

LAMP2
Lysosome-associated membrane glycoprotein 2

2

3

High-throughput

0.549

High

274289

STK16
Serine/threonine-protein kinase 16

1

4

High-throughput

0.536

High

592001

RAB4A
Ras-related protein Rab-4A

2

4

High-throughput

0.533

High

1216552

ZDH17
Palmitoyltransferase ZDHHC17

1

10

High-throughput

0.532

High

228616

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.515

High

358885

CRYAA
Alpha-crystallin A chain

1

2

High-throughput

0.515

High

388711

HSPB1
Heat shock protein beta-1

1

2

High-throughput

0.515

High

414054

GELS
Gelsolin

1

1

High-throughput

0.515

High

657976

CLAT
Choline O-acetyltransferase

1

2

High-throughput

0.515

High

893473

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.515

High

919256

RAN
GTP-binding nuclear protein Ran

1

5

High-throughput

0.515

High

1191561

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

14

High-throughput

0.515

High

1271956

KLK6
Kallikrein-6

1

1

High-throughput

0.515

High

1318596

UBQL1
Ubiquilin-1

1

1

High-throughput

0.515

High

326204

TSN15
Tetraspanin-15

1

0

High-throughput

0.513

High

1291183

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1318599

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.513

High

685008

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.493

High

877138

CASP6
Caspase-6

1

0

High-throughput

0.493

High

1216477

ZDH13
Palmitoyltransferase ZDHHC13

1

10

High-throughput

0.489

High

212993

STX6
Syntaxin-6

1

1

High-throughput

0.479

High

567252

CXA1
Gap junction alpha-1 protein

1

1

High-throughput

0.479

High

591673

RAB3B
Ras-related protein Rab-3B

1

2

High-throughput

0.479

High

592476

RAB5A
Ras-related protein Rab-5A

1

5

High-throughput

0.479

High

648877

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.479

High

670196

MARCS
Myristoylated alanine-rich C-kinase substrate

1

1

High-throughput

0.479

High

793458

MUC18
Cell surface glycoprotein MUC18

1

5

High-throughput

0.479

High

845713

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

892577

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

894397

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

895255

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.479

High

900869

RHOA
Transforming protein RhoA

1

6

High-throughput

0.479

High

915950

RHOB
Rho-related GTP-binding protein RhoB

1

7

High-throughput

0.479

High

924846

GRB2
Growth factor receptor-bound protein 2

1

15

Small-scale

0.479

High

925591

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

940553

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.479

High

951306

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

975006

CAV1
Caveolin-1

1

1

High-throughput

0.479

High

1070382

RAB35
Ras-related protein Rab-35

1

2

High-throughput

0.479

High

1076743

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.479

High

1083887

NTRK2
BDNF/NT-3 growth factors receptor

1

3

High-throughput

0.479

High

1183540

RHOU
Rho-related GTP-binding protein RhoU

1

10

High-throughput

0.479

High

47305

A0A6Q8PF08
Peripheral myelin protein 22

1

2

High-throughput

0.470

High

103840

G5E9A7
DM1 locus, WD repeat containing

1

3

High-throughput

0.470

High

231707

KIF1B
Kinesin-like protein KIF1B

1

4

High-throughput

0.470

High

281872

WFS1
Wolframin

1

2

High-throughput

0.470

High

427118

CATD
Cathepsin D

1

2

High-throughput

0.470

High

609519

FGFR3
Fibroblast growth factor receptor 3

1

4

High-throughput

0.470

High

660695

GRN
Progranulin

1

4

High-throughput

0.470

High

1200918

Q86V38
Atrophin 1

1

1

High-throughput

0.470

High

1318598

RNF11
RING finger protein 11

1

1

High-throughput

0.470

High

166304

GRRE1
Granule associated Rac and RHOG effector protein 1

1

0

High-throughput

0.458

High

364424

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.458

High

913092

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

925998

AP2B1
AP-2 complex subunit beta

1

0

High-throughput

0.458

High

1318594

ANFY1
Rabankyrin-5

1

0

High-throughput

0.458

High

1047251

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

1

High-throughput

0.445

High

169601

BET1
BET1 homolog

1

1

High-throughput

0.437

High

205945

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

564674

RHOQ
Rho-related GTP-binding protein RhoQ

1

9

High-throughput

0.437

High

844718

RAB5C
Ras-related protein Rab-5C

1

5

High-throughput

0.437

High

884584

RAB25
Ras-related protein Rab-25

1

3

High-throughput

0.437

High

1152082

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.437

High

1153734

STYK1
Tyrosine-protein kinase STYK1

1

6

High-throughput

0.437

High

1230357

CXD3
Gap junction delta-3 protein

1

1

High-throughput

0.437

High

1318591

RHOJ
Rho-related GTP-binding protein RhoJ

1

9

High-throughput

0.437

High

1318597

LAMP3
Lysosome-associated membrane glycoprotein 3

1

3

High-throughput

0.437

High

1230220

ORML3
ORM1-like protein 3

2

0

High-throughput

0.319

High

650146

CO8A1
Collagen alpha-1(VIII) chain

2

0

High-throughput

0.316

High

426798

ASGR1
Asialoglycoprotein receptor 1

1

0

High-throughput

0.279

Low

1318593

MYOF
Myoferlin

1

0

High-throughput

0.279

Low

263820

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.268

Low

363650

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

413165

CCKN
Cholecystokinin

1

0

High-throughput

0.268

Low

1246639

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

132582

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.249

Low

178759

STX7
Syntaxin-7

1

0

High-throughput

0.249

Low

305617

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.249

Low

825533

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.249

Low

1087605

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1203836

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1283051

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.249

Low

1318592

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.249

Low

1318595

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.249

Low

240173

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024