Protein: COMD4
COMM domain-containing protein 4

Gene: COMD4, COMMD4
Organism: Homo sapiens
Interactions: 93
UniProt ID: Q9H0A8

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

257174

CCD22
Coiled-coil domain-containing protein 22

7

1

Small-scale

0.967

High

1201155

CCD93
Coiled-coil domain-containing protein 93

6

1

Small-scale

0.945

High

1429668

COMD3
COMM domain-containing protein 3

6

1

High-throughput

0.943

High

1429676

COMDA
COMM domain-containing protein 10

5

5

High-throughput

0.925

High

1328845

COMD1
COMM domain-containing protein 1

8

0

Small-scale

0.917

High

1429666

COMD8
COMM domain-containing protein 8

8

0

High-throughput

0.917

High

1278362

COMD6
COMM domain-containing protein 6

6

0

High-throughput

0.895

High

1293504

COMD2
COMM domain-containing protein 2

6

0

High-throughput

0.895

High

1429667

COMD9
COMM domain-containing protein 9

6

0

High-throughput

0.895

High

1428325

COMD5
COMM domain-containing protein 5

5

0

High-throughput

0.877

High

1291794

COMD7
COMM domain-containing protein 7

6

0

High-throughput

0.789

High

1122866

TFDP1
Transcription factor Dp-1

4

1

High-throughput

0.699

High

1277150

VP35L
VPS35 endosomal protein-sorting factor-like

6

0

High-throughput

0.699

High

171106

VP26C
Vacuolar protein sorting-associated protein 26C

5

0

High-throughput

0.686

High

282780

E2F6
Transcription factor E2F6

5

0

High-throughput

0.686

High

1429669

VPS29
Vacuolar protein sorting-associated protein 29

4

0

High-throughput

0.667

High

1118328

EXOS2
Exosome complex component RRP4

3

0

High-throughput

0.622

High

789218

NUP62
Nuclear pore glycoprotein p62

2

0

High-throughput

0.576

High

1429677

R4GMX3
Polycomb complex protein BMI-1

1

2

High-throughput

0.575

High

1429662

EXOS4
Exosome complex component RRP41

2

1

High-throughput

0.571

High

754981

H2B1B
Histone H2B type 1-B

1

0

Small-scale

0.537

High

626360

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

2

Small-scale

0.536

High

1030034

RELB
Transcription factor RelB

1

2

Small-scale

0.536

High

1045750

TF65
Transcription factor p65

1

2

Small-scale

0.536

High

1122894

TFDP2
Transcription factor Dp-2

1

1

High-throughput

0.536

High

1311278

CHERP
Calcium homeostasis endoplasmic reticulum protein

1

2

High-throughput

0.536

High

251807

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

0

High-throughput

0.518

High

175779

SR140
U2 snRNP-associated SURP motif-containing protein

1

0

High-throughput

0.513

High

207648

DHX15
ATP-dependent RNA helicase DHX15

1

0

High-throughput

0.513

High

286068

SF3B1
Splicing factor 3B subunit 1

1

0

High-throughput

0.513

High

597011

TSHR
Thyrotropin receptor

1

0

High-throughput

0.513

High

838783

MTREX
Exosome RNA helicase MTR4

1

0

High-throughput

0.513

High

843966

HD
Huntingtin

1

0

High-throughput

0.513

High

925975

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

1065421

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1105409

SF3B2
Splicing factor 3B subunit 2

1

0

High-throughput

0.513

High

1128473

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

0

High-throughput

0.513

High

1243432

CNKR3
Connector enhancer of kinase suppressor of ras 3

1

0

High-throughput

0.513

High

1252032

TRI72
Tripartite motif-containing protein 72

1

0

High-throughput

0.513

High

1259489

TBA1A
Tubulin alpha-1A chain

1

0

High-throughput

0.513

High

1340037

O13G1
Olfactory receptor 13G1

1

0

High-throughput

0.513

High

1360473

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.513

High

1371926

STMN2
Stathmin-2

1

0

High-throughput

0.513

High

1380961

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.513

High

1390381

CCD97
Coiled-coil domain-containing protein 97

1

0

High-throughput

0.513

High

1394557

RSRC1
Serine/Arginine-related protein 53

1

0

High-throughput

0.513

High

1429664

GPTC2
G patch domain-containing protein 2

1

0

High-throughput

0.513

High

1429665

ARGL1
Arginine and glutamate-rich protein 1

1

0

High-throughput

0.513

High

1429670

APEX2
DNA-(apurinic or apyrimidinic site) endonuclease 2

1

0

High-throughput

0.513

High

1429671

GGT7
Glutathione hydrolase 7

1

0

High-throughput

0.513

High

1429672

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

0

High-throughput

0.513

High

1429673

CD11A
Cyclin-dependent kinase 11A

1

0

High-throughput

0.513

High

1429674

RBMX2
RNA-binding motif protein, X-linked 2

1

0

High-throughput

0.513

High

1429675

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

1311560

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.489

High

1397649

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

1397803

ODAD1
Outer dynein arm-docking complex subunit 1

1

2

High-throughput

0.489

High

1403419

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

1218009

MYOME
Myomegalin

1

0

Small-scale

0.484

High

419192

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.480

High

1413739

TBCD
Tubulin-specific chaperone D

1

0

Small-scale

0.480

High

272751

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

1

Small-scale

0.479

High

331307

KI20A
Kinesin-like protein KIF20A

1

2

High-throughput

0.479

High

765872

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.479

High

1035902

KIF23
Kinesin-like protein KIF23

1

1

High-throughput

0.479

High

1399092

SCLT1
Sodium channel and clathrin linker 1

1

1

High-throughput

0.479

High

157832

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

223318

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

290146

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

294307

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

373106

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

1140826

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1143524

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

1334168

POC1A
POC1 centriolar protein homolog A

1

0

High-throughput

0.458

High

1402176

PRPK
EKC/KEOPS complex subunit TP53RK

1

0

High-throughput

0.458

High

1429659

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1429661

CPAP
Centrosomal P4.1-associated protein

1

0

High-throughput

0.458

High

1429663

ANLN
Anillin

1

0

High-throughput

0.458

High

1137665

EXOS7
Exosome complex component RRP42

1

1

High-throughput

0.445

High

47571

RPSA2
Small ribosomal subunit protein uS2B

1

0

High-throughput

0.426

High

166565

BACH1
Transcription regulator protein BACH1

1

0

High-throughput

0.426

High

1271270

SV2B
Synaptic vesicle glycoprotein 2B

1

0

High-throughput

0.426

High

1384259

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.426

High

1349634

DEN10
DENN domain-containing protein 10

5

0

High-throughput

0.373

High

1099527

SRSF6
Serine/arginine-rich splicing factor 6

1

0

High-throughput

0.279

Low

1180496

C19L2
CWF19-like protein 2

1

0

High-throughput

0.279

Low

1388938

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1394004

SPF45
Splicing factor 45

1

0

High-throughput

0.279

Low

63316

ODAD3
Outer dynein arm-docking complex subunit 3

1

0

High-throughput

0.249

Low

879450

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

1209045

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.249

Low

1226521

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

1429660

SACA1
Sperm acrosome membrane-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025