Protein: XAF1
XIAP-associated factor 1 (BIRC4-binding protein)

Gene: XAF1
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q6GPH4

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1232909

RN114
E3 ubiquitin-protein ligase RNF114

6

5

Small-scale

0.739

High

1022733

XIAP
E3 ubiquitin-protein ligase XIAP

6

5

Small-scale

0.732

High

728293

AKT1
RAC-alpha serine/threonine-protein kinase

4

1

Small-scale

0.702

High

1232900

RN166
E3 ubiquitin-protein ligase RNF166

4

7

Small-scale

0.702

High

1232901

BIRC7
Baculoviral IAP repeat-containing protein 7

3

4

Small-scale

0.660

High

623389

RO52
E3 ubiquitin-protein ligase TRIM21

2

3

High-throughput

0.606

High

1232895

LRSM1
E3 ubiquitin-protein ligase LRSAM1

2

1

High-throughput

0.606

High

1232896

TRI50
E3 ubiquitin-protein ligase TRIM50

2

2

High-throughput

0.606

High

1232897

TRIMM
Probable E3 ubiquitin-protein ligase TRIML2

2

3

High-throughput

0.606

High

1232905

TRI54
Tripartite motif-containing protein 54

2

4

High-throughput

0.606

High

533943

IRF1
Interferon regulatory factor 1

2

0

Small-scale

0.598

High

829102

RFC5
Replication factor C subunit 5

2

0

High-throughput

0.580

High

892295

SPS1
Selenide, water dikinase 1

2

0

High-throughput

0.580

High

934743

TERA
Transitional endoplasmic reticulum ATPase

2

0

High-throughput

0.580

High

1135597

UBX2B
UBX domain-containing protein 2B

2

0

High-throughput

0.580

High

1232908

GLSL
Glutaminase liver isoform, mitochondrial

2

0

High-throughput

0.580

High

535181

BIP
Endoplasmic reticulum chaperone BiP

1

1

Small-scale

0.561

High

799209

BRCA1
Breast cancer type 1 susceptibility protein

1

2

Small-scale

0.561

High

211571

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.552

High

396315

ESR1
Estrogen receptor

1

0

Small-scale

0.537

High

414023

P53
Cellular tumor antigen p53

1

0

Small-scale

0.537

High

1232899

CBP
CREB-binding protein

1

0

Small-scale

0.537

High

728600

AKT2
RAC-beta serine/threonine-protein kinase

1

1

High-throughput

0.536

High

1232903

TRI11
E3 ubiquitin-protein ligase TRIM11

1

2

High-throughput

0.536

High

1232904

TRI47
E3 ubiquitin-protein ligase TRIM47

1

3

High-throughput

0.536

High

1106954

BIRC3
Baculoviral IAP repeat-containing protein 3

1

4

Small-scale

0.515

High

1107415

BIRC2
Baculoviral IAP repeat-containing protein 2

1

4

Small-scale

0.515

High

1212159

DPS1
All trans-polyprenyl-diphosphate synthase PDSS1

1

0

High-throughput

0.513

High

1232894

TATD1
Deoxyribonuclease TATDN1

1

0

High-throughput

0.513

High

1232902

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.513

High

1232906

ASPC1
Tether containing UBX domain for GLUT4

1

0

High-throughput

0.513

High

422321

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

163122

CHK1
Serine/threonine-protein kinase Chk1

1

1

Small-scale

0.479

High

1030937

TSPY1
Testis-specific Y-encoded protein 1

1

1

High-throughput

0.479

High

1090714

TRAF2
TNF receptor-associated factor 2

1

9

Small-scale

0.479

High

1093795

BIRC1
Baculoviral IAP repeat-containing protein 1

1

4

Small-scale

0.479

High

1109612

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

4

Small-scale

0.479

High

1232907

HIPK2
Homeodomain-interacting protein kinase 2

1

2

Small-scale

0.479

High

511000

TSPY3
Testis-specific Y-encoded protein 3

1

1

High-throughput

0.445

High

1187638

T10IP
Testis-specific protein 10-interacting protein

1

0

High-throughput

0.279

Low

1232898

OR4X2
Olfactory receptor 4X2

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025