Protein: CHK1
Serine/threonine-protein kinase Chk1 (EC 2.7.11.1) (CHK1 checkpoint homolog) (Cell cycle checkpoint kinase) (Checkpoint kinase-1)

Gene: CHK1, CHEK1
Organism: Homo sapiens
Interactions: 197
UniProt ID: O14757

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000785 - chromatin
GO:0000794 - condensed nuclear chromosome
GO:0001833 - inner cell mass cell proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

163056

MPIP3
M-phase inducer phosphatase 3

17

3

Small-scale

0.987

High

163054

MPIP1
M-phase inducer phosphatase 1

9

3

Small-scale

0.972

High

163113

CDC37
Hsp90 co-chaperone Cdc37

3

1

High-throughput

0.871

High

163010

CHK1
Serine/threonine-protein kinase Chk1

3

16

Small-scale

0.847

High

163035

HS90A
Heat shock protein HSP 90-alpha

3

3

Small-scale

0.834

High

163112

DDB1
DNA damage-binding protein 1

4

0

Small-scale

0.828

High

163164

RGAP1
Rac GTPase-activating protein 1

2

1

High-throughput

0.811

High

163161

CLPB
Mitochondrial disaggregase

3

0

High-throughput

0.803

High

163141

NEK9
Serine/threonine-protein kinase Nek9

2

12

Small-scale

0.789

High

163082

CSK2B
Casein kinase II subunit beta

2

0

Small-scale

0.788

High

163175

LATS2
Serine/threonine-protein kinase LATS2

2

1

Small-scale

0.778

High

163036

HS90B
Heat shock protein HSP 90-beta

2

3

Small-scale

0.776

High

163083

CSK21
Casein kinase II subunit alpha

2

6

Small-scale

0.768

High

163167

CLSPN
Claspin

13

2

Small-scale

0.762

High

163100

ATR
Serine/threonine-protein kinase ATR

10

4

Small-scale

0.752

High

163055

MPIP2
M-phase inducer phosphatase 2

1

3

Small-scale

0.747

High

163086

XIAP
E3 ubiquitin-protein ligase XIAP

1

1

Small-scale

0.747

High

163014

PPM1D
Protein phosphatase 1D

1

5

Small-scale

0.724

High

163075

RD23A
UV excision repair protein RAD23 homolog A

1

1

Small-scale

0.724

High

163102

CUL1
Cullin-1

6

2

Small-scale

0.721

High

163150

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

7

0

Small-scale

0.712

High

163011

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

Small-scale

0.708

High

163031

KPCB
Protein kinase C beta type

2

0

High-throughput

0.699

High

163028

P53
Cellular tumor antigen p53

6

0

Small-scale

0.692

High

163033

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.691

High

163080

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.691

High

163079

RHOB
Rho-related GTP-binding protein RhoB

1

0

Small-scale

0.687

High

163185

DBF4A
Protein DBF4 homolog A

1

0

Small-scale

0.687

High

163196

SCML2
Sex comb on midleg-like protein 2

1

0

Small-scale

0.687

High

163103

CUL4A
Cullin-4A

4

2

Small-scale

0.676

High

163064

BRCA1
Breast cancer type 1 susceptibility protein

3

2

Small-scale

0.660

High

163019

PLPL9
85/88 kDa calcium-independent phospholipase A2

1

0

High-throughput

0.656

High

163040

RAP2A
Ras-related protein Rap-2a

1

0

High-throughput

0.656

High

163048

VAV
Proto-oncogene vav

1

0

High-throughput

0.656

High

163097

SNTB2
Beta-2-syntrophin

1

0

High-throughput

0.656

High

163138

ZBT34
Zinc finger and BTB domain-containing protein 34

1

0

High-throughput

0.656

High

163057

1433B
14-3-3 protein beta/alpha

3

8

Small-scale

0.650

High

163039

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.647

High

163094

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

13

Small-scale

0.647

High

163162

ILKAP
Integrin-linked kinase-associated serine/threonine phosphatase 2C

1

20

Small-scale

0.647

High

163190

TLK1
Serine/threonine-protein kinase tousled-like 1

1

10

Small-scale

0.647

High

163078

1433G
14-3-3 protein gamma

2

9

Small-scale

0.639

High

124140

HAX1
HCLS1-associated protein X-1

3

0

High-throughput

0.638

High

163110

TCAL1
Transcription elongation factor A protein-like 1

3

0

High-throughput

0.638

High

163160

B2L14
Apoptosis facilitator Bcl-2-like protein 14

3

0

High-throughput

0.638

High

163107

I13R2
Interleukin-13 receptor subunit alpha-2

3

0

High-throughput

0.634

High

163062

FUS
RNA-binding protein FUS

1

0

High-throughput

0.631

High

163178

DTL
Denticleless protein homolog

2

1

Small-scale

0.629

High

163046

CATE
Cathepsin E

2

1

High-throughput

0.628

High

163089

1433F
14-3-3 protein eta

2

8

High-throughput

0.628

High

163143

DNJB3
DnaJ homolog subfamily B member 3

1

1

High-throughput

0.618

High

163049

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

1

Small-scale

0.618

High

163133

KSR1
Kinase suppressor of Ras 1

1

2

High-throughput

0.618

High

163159

WNK3
Serine/threonine-protein kinase WNK3

1

13

High-throughput

0.618

High

163090

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.612

High

163200

SNX11
Sorting nexin-11

2

1

High-throughput

0.611

High

163096

ATM
Serine-protein kinase ATM

2

4

Small-scale

0.608

High

163087

CNTN2
Contactin-2

1

0

Small-scale

0.606

High

163015

PA2GX
Group 10 secretory phospholipase A2

2

0

High-throughput

0.602

High

163114

ERC6L
DNA excision repair protein ERCC-6-like

2

0

High-throughput

0.602

High

163130

DAA11
Dynein axonemal assembly factor 11

2

0

High-throughput

0.602

High

163155

NAT9
Alpha/beta-tubulin-N-acetyltransferase 9

2

0

High-throughput

0.602

High

163053

1433T
14-3-3 protein theta

2

8

High-throughput

0.601

High

163013

MDM4
Protein Mdm4

2

0

Small-scale

0.598

High

163034

NPM
Nucleophosmin

2

0

Small-scale

0.598

High

163192

FZR1
Fizzy-related protein homolog

2

0

Small-scale

0.598

High

163063

ZEB1
Zinc finger E-box-binding homeobox 1

1

0

Small-scale

0.586

High

163065

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

Small-scale

0.586

High

163066

CCNF
Cyclin-F

1

0

High-throughput

0.586

High

163123

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.586

High

163166

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.586

High

163173

KI13B
Kinesin-like protein KIF13B

1

0

High-throughput

0.586

High

163189

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.586

High

163191

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.586

High

163169

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

Small-scale

0.586

High

163117

ARH
Low density lipoprotein receptor adapter protein 1

2

0

High-throughput

0.585

High

163081

1433Z
14-3-3 protein zeta/delta

2

9

Small-scale

0.584

High

163183

HDAC6
Protein deacetylase HDAC6

1

1

Small-scale

0.578

High

163136

PACE1
Protein-associating with the carboxyl-terminal domain of ezrin

1

10

High-throughput

0.575

High

163085

PRKDC
DNA-dependent protein kinase catalytic subunit

2

4

Small-scale

0.571

High

163018

CC14B
Dual specificity protein phosphatase CDC14B

1

3

Small-scale

0.561

High

163061

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.561

High

163070

MCM2
DNA replication licensing factor MCM2

1

5

Small-scale

0.561

High

163106

MCM6
DNA replication licensing factor MCM6

1

5

Small-scale

0.561

High

163128

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

1

Small-scale

0.561

High

163052

DNMT1
DNA

2

0

Small-scale

0.559

High

163105

BTG3
Protein BTG3

2

0

Small-scale

0.559

High

163074

ATX3
Ataxin-3

1

0

Small-scale

0.554

High

163156

TRAF4
TNF receptor-associated factor 4

1

0

Small-scale

0.554

High

163202

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

Small-scale

0.554

High

163099

SQSTM
Sequestosome-1

1

0

High-throughput

0.546

High

163032

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.544

High

74105

VWC2L
von Willebrand factor C domain-containing protein 2-like

1

1

High-throughput

0.536

High

163037

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.536

High

163147

NELL1
Protein kinase C-binding protein NELL1

1

1

High-throughput

0.536

High

163154

CDC5L
Cell division cycle 5-like protein

1

9

High-throughput

0.536

High

163179

RN181
E3 ubiquitin-protein ligase RNF181

1

2

High-throughput

0.536

High

163182

RBX2
RING-box protein 2

1

2

High-throughput

0.536

High

163180

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.517

High

163016

RNF13
E3 ubiquitin-protein ligase RNF13

1

0

High-throughput

0.513

High

163020

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.513

High

163068

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

163101

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

163120

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

163121

H2A2A
Histone H2A type 2-A

1

0

High-throughput

0.513

High

163132

UN5CL
UNC5C-like protein

1

0

High-throughput

0.513

High

163137

EIF1A
Probable RNA-binding protein EIF1AD

1

0

High-throughput

0.513

High

163139

DDHD1
Phospholipase DDHD1

1

0

High-throughput

0.513

High

163145

H1X
Histone H1.10

1

0

High-throughput

0.513

High

163148

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

163186

FBLN5
Fibulin-5

1

0

High-throughput

0.513

High

163201

WNT6
Protein Wnt-6

1

0

High-throughput

0.513

High

163050

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

2

Small-scale

0.501

High

163088

TF65
Transcription factor p65

1

3

Small-scale

0.501

High

163091

B2CL1
Bcl-2-like protein 1

1

1

Small-scale

0.501

High

163146

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

Small-scale

0.501

High

163184

SAE2
SUMO-activating enzyme subunit 2

1

2

Small-scale

0.501

High

128613

MEN1
Menin

1

0

Small-scale

0.493

High

163193

TIM
Protein timeless homolog

1

0

Small-scale

0.493

High

163012

XPO1
Exportin-1

1

0

Small-scale

0.480

High

163029

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

163041

TAU
Microtubule-associated protein tau

1

0

Small-scale

0.480

High

163043

CADH1
Cadherin-1

1

0

Small-scale

0.480

High

163071

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.480

High

163093

TP53B
TP53-binding protein 1

1

0

Small-scale

0.480

High

163111

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

Small-scale

0.480

High

163140

MCPH1
Microcephalin

1

0

Small-scale

0.480

High

163149

BAD
Bcl2-associated agonist of cell death

1

0

Small-scale

0.480

High

163157

FACD2
Fanconi anemia group D2 protein

1

0

Small-scale

0.480

High

163168

FANCE
Fanconi anemia group E protein

1

0

Small-scale

0.480

High

163170

UBE2T
Ubiquitin-conjugating enzyme E2 T

1

0

Small-scale

0.480

High

163022

CDC45
Cell division control protein 45 homolog

1

1

Small-scale

0.479

High

163026

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

1

Small-scale

0.479

High

163027

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

3

High-throughput

0.479

High

163042

PCNA
Proliferating cell nuclear antigen

1

3

Small-scale

0.479

High

163044

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

163045

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

163051

MCM3
DNA replication licensing factor MCM3

1

5

Small-scale

0.479

High

163058

1433S
14-3-3 protein sigma

1

9

Small-scale

0.479

High

163059

MCM4
DNA replication licensing factor MCM4

1

4

Small-scale

0.479

High

163060

MCM5
DNA replication licensing factor MCM5

1

4

Small-scale

0.479

High

163067

MSH2
DNA mismatch repair protein Msh2

1

1

Small-scale

0.479

High

163072

MSH6
DNA mismatch repair protein Msh6

1

1

Small-scale

0.479

High

163073

BLM
RecQ-like DNA helicase BLM

1

1

Small-scale

0.479

High

163076

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

163077

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

163084

H31
Histone H3.1

1

2

Small-scale

0.479

High

163092

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

1

Small-scale

0.479

High

163095

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

163098

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

3

High-throughput

0.479

High

163122

XAF1
XIAP-associated factor 1

1

1

Small-scale

0.479

High

163127

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

3

High-throughput

0.479

High

163163

BRD8
Bromodomain-containing protein 8

1

2

High-throughput

0.479

High

163171

BRD7
Bromodomain-containing protein 7

1

1

Small-scale

0.479

High

163181

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.479

High

163194

TRI33
E3 ubiquitin-protein ligase TRIM33

1

1

High-throughput

0.479

High

163197

FBW1A
F-box/WD repeat-containing protein 1A

1

1

Small-scale

0.479

High

163017

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

163021

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

163023

GGYF1
GRB10-interacting GYF protein 1

1

0

High-throughput

0.458

High

163024

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

163038

DPOLA
DNA polymerase alpha catalytic subunit

1

0

Small-scale

0.458

High

163047

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

Small-scale

0.458

High

163104

FHL1
Four and a half LIM domains protein 1

1

0

Small-scale

0.458

High

163108

PSF1
DNA replication complex GINS protein PSF1

1

0

Small-scale

0.458

High

163109

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

163116

SETMR
Histone-lysine N-methyltransferase SETMAR

1

0

Small-scale

0.458

High

163119

SPD2A
SH3 and PX domain-containing protein 2A

1

0

High-throughput

0.458

High

163126

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

163129

GLCI1
Glucocorticoid-induced transcript 1 protein

1

0

High-throughput

0.458

High

163131

DZIP3
E3 ubiquitin-protein ligase DZIP3

1

0

Small-scale

0.458

High

163142

DEN1A
DENN domain-containing protein 1A

1

0

High-throughput

0.458

High

163144

DGCR8
Microprocessor complex subunit DGCR8

1

0

Small-scale

0.458

High

163153

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

Small-scale

0.458

High

163158

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

163174

FBX6
F-box only protein 6

1

0

Small-scale

0.458

High

163177

MTMR4
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR4

1

0

High-throughput

0.458

High

163195

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

0

High-throughput

0.458

High

163198

CBY1
Protein chibby homolog 1

1

0

High-throughput

0.458

High

163124

CR3L2
Cyclic AMP-responsive element-binding protein 3-like protein 2

1

10

High-throughput

0.445

High

163188

ERRFI
ERBB receptor feedback inhibitor 1

1

1

Small-scale

0.445

High

163025

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

163030

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

163135

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.426

High

163176

AATF
Protein AATF

1

0

Small-scale

0.426

High

163069

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

163187

ACHA9
Neuronal acetylcholine receptor subunit alpha-9

3

0

High-throughput

0.347

High

163115

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

3

0

High-throughput

0.345

High

163172

MEPE
Matrix extracellular phosphoglycoprotein

1

0

Small-scale

0.288

High

163165

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

0

High-throughput

0.282

High

163118

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

0

High-throughput

0.279

Low

163125

MTSS2
Protein MTSS 2

1

0

High-throughput

0.279

Low

163151

HVCN1
Voltage-gated hydrogen channel 1

1

0

High-throughput

0.279

Low

163134

MILK2
MICAL-like protein 2

1

0

High-throughput

0.249

Low

163152

T3HPD
Trans-3-hydroxy-L-proline dehydratase

1

0

High-throughput

0.249

Low

163199

KCTD3
BTB/POZ domain-containing protein KCTD3

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025