Protein: DRD4
D(4) dopamine receptor (D(2C) dopamine receptor) (Dopamine D4 receptor)

Gene: DRD4
Organism: Homo sapiens
Interactions: 33
UniProt ID: P21917

Gene Ontology (top 5):
GO:0001591 - dopamine neurotransmitter receptor activity, coupled via Gi/Go
GO:0001662 - behavioral fear response
GO:0001975 - response to amphetamine
GO:0004952 - dopamine neurotransmitter receptor activity
GO:0004993 - G protein-coupled serotonin receptor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

641879

ARRB2
Beta-arrestin-2

2

10

Small-scale

0.754

High

458277

ADRB2
Beta-2 adrenergic receptor

1

17

Small-scale

0.724

High

472218

ADRB1
Beta-1 adrenergic receptor

1

15

Small-scale

0.665

High

641880

ADA1B
Alpha-1B adrenergic receptor

1

20

Small-scale

0.665

High

641887

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

11

Small-scale

0.647

High

572409

DRD2
D(2) dopamine receptor

1

17

Small-scale

0.618

High

641878

DRD4
D(4) dopamine receptor

1

18

Small-scale

0.618

High

641883

ARRB1
Beta-arrestin-1

1

10

Small-scale

0.618

High

641891

CUL3
Cullin-3

2

2

Small-scale

0.584

High

641888

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

High-throughput

0.536

High

641890

ATM
Serine-protein kinase ATM

1

5

High-throughput

0.536

High

641894

INT1
Integrator complex subunit 1

1

1

High-throughput

0.536

High

641896

CTR3
Cationic amino acid transporter 3

1

3

High-throughput

0.536

High

593908

NCK1
SH2/SH3 adapter protein NCK1

1

9

Small-scale

0.501

High

641886

GRB2
Growth factor receptor-bound protein 2

1

11

Small-scale

0.501

High

641889

ADCY2
Adenylate cyclase type 2

1

1

Small-scale

0.501

High

421501

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

607289

NEUM
Neuromodulin

1

0

High-throughput

0.493

High

641884

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.493

High

641885

STXB1
Syntaxin-binding protein 1

1

0

High-throughput

0.493

High

164527

TNPO2
Transportin-2

1

9

High-throughput

0.489

High

641893

D19L3
Protein C-mannosyl-transferase DPY19L3

1

1

High-throughput

0.489

High

641895

ARL10
ADP-ribosylation factor-like protein 10

1

6

High-throughput

0.489

High

641900

PIGM
GPI alpha-1,4-mannosyltransferase I, catalytic subunit

1

1

High-throughput

0.489

High

641901

MRS2
Magnesium transporter MRS2 homolog, mitochondrial

1

2

High-throughput

0.489

High

641898

CLIC6
Chloride intracellular channel protein 6

1

2

Small-scale

0.481

High

641881

KCNJ5
G protein-activated inward rectifier potassium channel 4

1

8

Small-scale

0.479

High

641882

KCNJ3
G protein-activated inward rectifier potassium channel 1

1

8

Small-scale

0.479

High

641897

KCNJ9
G protein-activated inward rectifier potassium channel 3

1

8

Small-scale

0.479

High

641902

CHIP
E3 ubiquitin-protein ligase CHIP

1

3

Small-scale

0.437

High

641892

KLH12
Kelch-like protein 12

5

0

Small-scale

0.370

High

641899

NECA3
N-terminal EF-hand calcium-binding protein 3

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025