Protein: INT1
Integrator complex subunit 1 (Int1)

Gene: INT1, INTS1
Organism: Homo sapiens
Interactions: 184
UniProt ID: Q8N201

Gene Ontology (top 5):
GO:0001833 - inner cell mass cell proliferation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0007566 - embryo implantation
GO:0016020 - membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717896

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

4

1

High-throughput

0.906

High

1243311

INT5
Integrator complex subunit 5

2

1

High-throughput

0.789

High

1323827

INT4
Integrator complex subunit 4

2

0

High-throughput

0.716

High

994296

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

5

3

Small-scale

0.714

High

1323824

INT12
Integrator complex subunit 12

4

1

High-throughput

0.683

High

1323833

INT14
Integrator complex subunit 14

3

2

High-throughput

0.656

High

218448

TGON2
Trans-Golgi network integral membrane protein 2

3

0

High-throughput

0.638

High

50616

HACL2
2-hydroxyacyl-CoA lyase 2

3

0

High-throughput

0.634

High

396493

ESR1
Estrogen receptor

3

1

High-throughput

0.624

High

718147

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

1

High-throughput

0.618

High

638470

FPR1
fMet-Leu-Phe receptor

2

7

High-throughput

0.601

High

1323863

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

2

0

Small-scale

0.592

High

1323839

INT2
Integrator complex subunit 2

1

0

High-throughput

0.586

High

130538

SPT5H
Transcription elongation factor SPT5

2

0

High-throughput

0.585

High

723019

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.585

High

850899

KI2S2
Killer cell immunoglobulin-like receptor 2DS2

2

0

High-throughput

0.585

High

487520

PARP1
Poly [ADP-ribose] polymerase 1

2

1

High-throughput

0.584

High

977541

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

2

3

High-throughput

0.584

High

1323857

INT6
Integrator complex subunit 6

2

2

Small-scale

0.584

High

1323851

OCAD1
OCIA domain-containing protein 1

2

0

High-throughput

0.576

High

770887

OPRM
Mu-type opioid receptor

2

5

High-throughput

0.574

High

771172

APJ
Apelin receptor

2

5

High-throughput

0.574

High

879806

NPY2R
Neuropeptide Y receptor type 2

2

5

High-throughput

0.574

High

1323849

INT13
Integrator complex subunit 13

2

1

Small-scale

0.571

High

589141

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

695926

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768632

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

979973

H4
Histone H4

2

0

High-throughput

0.559

High

1323850

INT10
Integrator complex subunit 10

2

0

Small-scale

0.559

High

1101580

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

2

8

High-throughput

0.549

High

1291840

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

2

10

High-throughput

0.549

High

182654

GP182
G-protein coupled receptor 182

1

6

High-throughput

0.536

High

221460

OX2R
Orexin receptor type 2

1

4

High-throughput

0.536

High

634783

GRAH
Granzyme H

1

1

High-throughput

0.536

High

641894

DRD4
D(4) dopamine receptor

1

1

High-throughput

0.536

High

719809

V2R
Vasopressin V2 receptor

1

6

High-throughput

0.536

High

774491

BASI
Basigin

1

1

High-throughput

0.536

High

867986

GLR
Glucagon receptor

1

5

High-throughput

0.536

High

872524

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

1042759

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

1

4

High-throughput

0.536

High

1065297

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1316737

AGRG2
Adhesion G-protein coupled receptor G2

1

1

High-throughput

0.536

High

1323836

CML1
Chemerin-like receptor 1

1

7

High-throughput

0.536

High

209063

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.513

High

291837

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

303686

JTB
Protein JTB

1

0

High-throughput

0.513

High

344477

STR3N
STARD3 N-terminal-like protein

1

0

High-throughput

0.513

High

538638

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

0

High-throughput

0.513

High

621913

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

847782

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.513

High

923513

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

958997

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

1022422

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.513

High

1111104

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1291625

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.513

High

1323812

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1323817

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1323822

AQP3
Aquaporin-3

1

0

High-throughput

0.513

High

1323823

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

1323834

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

1323835

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.513

High

1323841

CXL16
C-X-C motif chemokine 16

1

0

High-throughput

0.513

High

1323856

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.513

High

1323859

FZD10
Frizzled-10

1

0

High-throughput

0.513

High

1323855

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

133277

P2Y10
Putative P2Y purinoceptor 10

1

9

High-throughput

0.489

High

165989

FFAR1
Free fatty acid receptor 1

1

8

High-throughput

0.489

High

210407

MTLR
Motilin receptor

1

6

High-throughput

0.489

High

406906

MAS
Proto-oncogene Mas

1

8

High-throughput

0.489

High

733019

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

4

High-throughput

0.489

High

754064

CD80
T-lymphocyte activation antigen CD80

1

1

High-throughput

0.489

High

832428

OPRX
Nociceptin receptor

1

4

High-throughput

0.489

High

833837

P2RY2
P2Y purinoceptor 2

1

9

High-throughput

0.489

High

835326

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

4

High-throughput

0.489

High

936083

PAR2
Proteinase-activated receptor 2

1

9

High-throughput

0.489

High

1323816

GP150
Probable G-protein coupled receptor 150

1

5

High-throughput

0.489

High

1323818

PKR1
Prokineticin receptor 1

1

5

High-throughput

0.489

High

1323862

GPR55
G-protein coupled receptor 55

1

9

High-throughput

0.489

High

1323864

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

1323865

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

621686

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.479

High

143115

NFIB
Nuclear factor 1 B-type

1

3

High-throughput

0.479

High

285362

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

474121

NFIC
Nuclear factor 1 C-type

1

4

High-throughput

0.479

High

897899

CDK9
Cyclin-dependent kinase 9

1

1

High-throughput

0.479

High

968375

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

4

High-throughput

0.479

High

998534

H31
Histone H3.1

1

1

High-throughput

0.479

High

1017016

H33
Histone H3.3

1

1

High-throughput

0.479

High

1087865

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1133530

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1206357

INT6L
Integrator complex subunit 6-like

1

2

High-throughput

0.479

High

1214993

INT11
Integrator complex subunit 11

1

3

High-throughput

0.479

High

1258257

UBP43
Ubiquitin carboxyl-terminal hydrolase 43

1

1

High-throughput

0.479

High

1323832

CIC
Protein capicua homolog

1

1

High-throughput

0.479

High

1323838

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

1323847

INT9
Integrator complex subunit 9

1

3

High-throughput

0.479

High

880939

MTR1B
Melatonin receptor type 1B

1

5

High-throughput

0.464

High

129251

MEN1
Menin

1

0

High-throughput

0.458

High

157602

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

242259

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

260174

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

412249

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

558265

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

654655

TCEA1
Transcription elongation factor A protein 1

1

0

High-throughput

0.458

High

667366

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

791525

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

807496

IF4A3
Eukaryotic initiation factor 4A-III

1

0

High-throughput

0.458

High

879266

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

904924

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

912087

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

937292

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

0

High-throughput

0.458

High

980921

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1004817

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1045509

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

1113669

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1124373

ELOA1
Elongin-A

1

0

Small-scale

0.458

High

1137389

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

1143034

CDK10
Cyclin-dependent kinase 10

1

0

High-throughput

0.458

High

1155539

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1220641

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1229172

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1260308

INT8
Integrator complex subunit 8

1

0

High-throughput

0.458

High

1276476

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1313018

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1323516

ZN687
Zinc finger protein 687

1

0

High-throughput

0.458

High

1323821

SIA8A
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

1

0

High-throughput

0.458

High

1323825

MBD6
Methyl-CpG-binding domain protein 6

1

0

High-throughput

0.458

High

1323829

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1323830

INT15
Integrator complex subunit 15

1

0

High-throughput

0.458

High

1323837

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.458

High

1323840

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

1323844

WDR76
WD repeat-containing protein 76

1

0

High-throughput

0.458

High

1323845

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1323848

INT7
Integrator complex subunit 7

1

0

High-throughput

0.458

High

1323852

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1323858

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

0

High-throughput

0.458

High

1323861

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

280423

DEAF1
Deformed epidermal autoregulatory factor 1 homolog

1

1

High-throughput

0.457

High

1323860

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.445

High

380090

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

0

High-throughput

0.426

High

954715

SEM1
26S proteasome complex subunit SEM1

1

0

High-throughput

0.426

High

1014156

CBX1
Chromobox protein homolog 1

1

0

Small-scale

0.426

High

1181397

P3H1
Prolyl 3-hydroxylase 1

1

0

High-throughput

0.426

High

1240898

S27A4
Long-chain fatty acid transport protein 4

1

0

High-throughput

0.426

High

1292839

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

1323813

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1323828

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.426

High

704041

5HT1E
5-hydroxytryptamine receptor 1E

1

1

High-throughput

0.407

High

1010948

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

906109

AL3A2
Aldehyde dehydrogenase family 3 member A2

3

0

High-throughput

0.347

High

275326

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

0

High-throughput

0.328

High

1323815

IQCF1
IQ domain-containing protein F1

2

0

High-throughput

0.318

High

230708

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

289360

CTAG2
Cancer/testis antigen 2

1

0

High-throughput

0.279

Low

378638

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

627905

TCO2
Transcobalamin-2

1

0

High-throughput

0.279

Low

749230

CD70
CD70 antigen

1

0

High-throughput

0.279

Low

914297

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1128920

I13R2
Interleukin-13 receptor subunit alpha-2

1

0

High-throughput

0.279

Low

1249808

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1251665

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1279328

DHB13
17-beta-hydroxysteroid dehydrogenase 13

1

0

High-throughput

0.279

Low

1281709

B3GN8
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8

1

0

High-throughput

0.279

Low

1292390

OSTM1
Osteopetrosis-associated transmembrane protein 1

1

0

High-throughput

0.279

Low

1323811

TM130
Transmembrane protein 130

1

0

High-throughput

0.279

Low

1323814

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

1323819

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1323826

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1323831

OPALI
Opalin

1

0

High-throughput

0.279

Low

1323854

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.279

Low

106254

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

472326

CFAH
Complement factor H

1

0

Small-scale

0.249

Low

581162

RAC2
Ras-related C3 botulinum toxin substrate 2

1

0

High-throughput

0.249

Low

1101283

SLAF1
Signaling lymphocytic activation molecule

1

0

High-throughput

0.249

Low

1254610

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1256918

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

1323842

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1323843

RPAP3
RNA polymerase II-associated protein 3

1

0

High-throughput

0.249

Low

1323853

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.249

Low

139267

UPK2
Uroplakin-2

1

0

High-throughput

0.232

Low

166344

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.232

Low

1219513

ANR22
Ankyrin repeat domain-containing protein 22

1

0

High-throughput

0.232

Low

1323820

CE192
Centrosomal protein of 192 kDa

1

0

High-throughput

0.232

Low

1323846

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025