Protein: 3BP5
SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK)

Gene: 3BP5, SH3BP5
Organism: Homo sapiens
Interactions: 30
UniProt ID: O60239

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

239417

RB11A
Ras-related protein Rab-11A

5

6

Small-scale

0.922

High

239422

RB11B
Ras-related protein Rab-11B

4

7

High-throughput

0.797

High

239409

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

3

3

Small-scale

0.645

High

239420

BTK
Tyrosine-protein kinase BTK

2

0

Small-scale

0.629

High

239429

DISC1
Disrupted in schizophrenia 1 protein

2

1

High-throughput

0.590

High

239408

3BP5
SH3 domain-binding protein 5

1

0

High-throughput

0.586

High

239424

IFT20
Intraflagellar transport protein 20 homolog

2

0

High-throughput

0.580

High

239428

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

3

Small-scale

0.576

High

239418

SPTB2
Spectrin beta chain, non-erythrocytic 1

2

1

High-throughput

0.576

High

239419

DYST
Dystonin

2

2

High-throughput

0.576

High

239425

SYNE1
Nesprin-1

2

3

High-throughput

0.576

High

239421

SOS1
Son of sevenless homolog 1

2

0

High-throughput

0.565

High

239431

EXOC1
Exocyst complex component 1

2

0

High-throughput

0.565

High

239427

CDC5L
Cell division cycle 5-like protein

2

0

High-throughput

0.551

High

239413

MK08
Mitogen-activated protein kinase 8

1

2

Small-scale

0.549

High

239416

TTC3
E3 ubiquitin-protein ligase TTC3

1

0

High-throughput

0.518

High

239410

ALBU
Albumin

1

0

High-throughput

0.513

High

239414

MK09
Mitogen-activated protein kinase 9

1

2

Small-scale

0.501

High

239415

MK10
Mitogen-activated protein kinase 10

1

2

Small-scale

0.501

High

239411

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

239423

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

239430

RN146
E3 ubiquitin-protein ligase RNF146

1

1

Small-scale

0.479

High

172304

XPO1
Exportin-1

1

0

High-throughput

0.458

High

239426

SYNE2
Nesprin-2

1

3

High-throughput

0.457

High

239434

ING4
Inhibitor of growth protein 4

1

0

High-throughput

0.438

High

239435

HPS5
BLOC-2 complex member HPS5

1

0

High-throughput

0.438

High

239433

NP1L2
Nucleosome assembly protein 1-like 2

2

0

High-throughput

0.316

High

239432

LIMA1
LIM domain and actin-binding protein 1

1

0

High-throughput

0.279

Low

239412

MA1A1
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025