Protein: TTP
mRNA decay activator protein ZFP36 (G0/G1 switch regulatory protein 24) (Growth factor-inducible nuclear protein NUP475) (Tristetraprolin) (Zinc finger protein 36) (Zfp-36)

Gene: TTP, ZFP36
Organism: Homo sapiens
Interactions: 166
UniProt ID: P26651

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000165 - MAPK cascade
GO:0000288 - nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 - nuclear-transcribed mRNA poly(A) tail shortening
GO:0000932 - P-body

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

550129

PABP1
Polyadenylate-binding protein 1

2

5

Small-scale

0.800

High

688220

1433B
14-3-3 protein beta/alpha

3

17

Small-scale

0.667

High

63960

CNOT1
CCR4-NOT transcription complex subunit 1

2

3

Small-scale

0.621

High

620142

NUCL
Nucleolin

1

5

Small-scale

0.621

High

340557

CNOT4
CCR4-NOT transcription complex subunit 4

1

2

High-throughput

0.618

High

688217

RBMS1
RNA-binding motif, single-stranded-interacting protein 1

1

6

High-throughput

0.618

High

688229

TIAR
Nucleolysin TIAR

1

4

High-throughput

0.618

High

688243

RBMS2
RNA-binding motif, single-stranded-interacting protein 2

1

6

High-throughput

0.618

High

688276

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

3

High-throughput

0.618

High

688277

RAVR1
Ribonucleoprotein PTB-binding 1

1

7

High-throughput

0.618

High

688292

FBXW7
F-box/WD repeat-containing protein 7

1

2

Small-scale

0.618

High

688311

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.618

High

688318

RC3H2
Roquin-2

1

6

High-throughput

0.618

High

688321

TNR6C
Trinucleotide repeat-containing gene 6C protein

1

9

High-throughput

0.618

High

688323

WDR6
tRNA

1

6

High-throughput

0.618

High

688329

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

12

High-throughput

0.618

High

688333

Z3H7B
Zinc finger CCCH domain-containing protein 7B

1

3

High-throughput

0.618

High

688349

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

12

High-throughput

0.618

High

688325

DCP1A
mRNA-decapping enzyme 1A

2

3

Small-scale

0.611

High

688224

MAPK2
MAP kinase-activated protein kinase 2

2

2

Small-scale

0.602

High

688278

DCP1B
mRNA-decapping enzyme 1B

2

5

Small-scale

0.586

High

688344

MARF1
Meiosis regulator and mRNA stability factor 1

1

0

High-throughput

0.586

High

688296

EDC3
Enhancer of mRNA-decapping protein 3

2

0

Small-scale

0.585

High

281285

GGYF1
GRB10-interacting GYF protein 1

2

2

Small-scale

0.584

High

688216

1433T
14-3-3 protein theta

2

17

Small-scale

0.584

High

688299

CNO6L
CCR4-NOT transcription complex subunit 6-like

2

4

Small-scale

0.584

High

688332

CNOT8
CCR4-NOT transcription complex subunit 8

2

6

Small-scale

0.584

High

688335

CNOT7
CCR4-NOT transcription complex subunit 7

2

6

Small-scale

0.584

High

688339

CNOT6
CCR4-NOT transcription complex subunit 6

2

5

Small-scale

0.584

High

688279

XRN1
5'-3' exoribonuclease 1

2

1

Small-scale

0.584

High

688232

MTG8
Protein CBFA2T1

2

0

High-throughput

0.580

High

688222

NU214
Nuclear pore complex protein Nup214

1

2

Small-scale

0.573

High

377975

TNFA
Tumor necrosis factor

2

0

Small-scale

0.569

High

688226

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.561

High

688239

FHL3
Four and a half LIM domains protein 3

1

3

High-throughput

0.560

High

688253

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

2

0

Small-scale

0.559

High

688221

HSP74
Heat shock 70 kDa protein 4

1

1

Small-scale

0.552

High

688295

SH3K1
SH3 domain-containing kinase-binding protein 1

1

3

Small-scale

0.552

High

688218

HXC9
Homeobox protein Hox-C9

1

1

High-throughput

0.541

High

688225

ANM2
Protein arginine N-methyltransferase 2

1

2

High-throughput

0.541

High

688247

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.541

High

688274

DCP2
m7GpppN-mRNA hydrolase

1

1

Small-scale

0.536

High

688231

1433F
14-3-3 protein eta

1

17

Small-scale

0.527

High

474494

VIME
Vimentin

1

1

High-throughput

0.515

High

688265

EDC4
Enhancer of mRNA-decapping protein 4

1

0

Small-scale

0.513

High

688228

CDK6
Cyclin-dependent kinase 6

1

4

Small-scale

0.501

High

688263

A16L1
Autophagy-related protein 16-1

1

0

Small-scale

0.500

High

688275

ZDH17
Palmitoyltransferase ZDHHC17

1

3

High-throughput

0.494

High

593725

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

688294

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.486

High

688317

RENT2
Regulator of nonsense transcripts 2

1

0

High-throughput

0.486

High

679069

DNJB1
DnaJ homolog subfamily B member 1

1

2

Small-scale

0.481

High

688258

EXOS6
Exosome complex component MTR3

1

1

High-throughput

0.481

High

421535

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

50389

MEX3A
RNA-binding protein MEX3A

1

14

High-throughput

0.479

High

67758

TBKB1
TANK-binding kinase 1-binding protein 1

1

2

High-throughput

0.479

High

91747

MCRI1
Mapk-regulated corepressor-interacting protein 1

1

2

High-throughput

0.479

High

172489

XPO1
Exportin-1

1

5

High-throughput

0.479

High

174936

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.479

High

176443

GRRE1
Granule associated Rac and RHOG effector protein 1

1

1

High-throughput

0.479

High

188180

HDAC3
Histone deacetylase 3

1

2

Small-scale

0.479

High

252012

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

1

High-throughput

0.479

High

258768

DNJA2
DnaJ homolog subfamily A member 2

1

2

High-throughput

0.479

High

273818

CNOT3
CCR4-NOT transcription complex subunit 3

1

8

High-throughput

0.479

High

274098

ANR17
Ankyrin repeat domain-containing protein 17

1

2

High-throughput

0.479

High

352326

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

445497

IF4E
Eukaryotic translation initiation factor 4E

1

1

High-throughput

0.479

High

469258

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

1

High-throughput

0.479

High

612879

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

626083

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.479

High

675375

TYY1
Transcriptional repressor protein YY1

1

2

Small-scale

0.479

High

684085

DDX6
Probable ATP-dependent RNA helicase DDX6

1

5

High-throughput

0.479

High

688219

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.479

High

688223

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

688230

OTUD4
OTU domain-containing protein 4

1

4

High-throughput

0.479

High

688235

TRAF2
TNF receptor-associated factor 2

1

2

Small-scale

0.479

High

688236

HDAC1
Histone deacetylase 1

1

4

Small-scale

0.479

High

688237

CUL4B
Cullin-4B

1

4

High-throughput

0.479

High

688238

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

11

High-throughput

0.479

High

688240

UBP2L
Ubiquitin-associated protein 2-like

1

4

High-throughput

0.479

High

688241

PUM1
Pumilio homolog 1

1

4

High-throughput

0.479

High

688242

R3HD1
R3H domain-containing protein 1

1

7

High-throughput

0.479

High

688246

TRIP6
Thyroid receptor-interacting protein 6

1

3

High-throughput

0.479

High

688248

HIF1A
Hypoxia-inducible factor 1-alpha

1

5

Small-scale

0.479

High

688249

CPEB4
Cytoplasmic polyadenylation element-binding protein 4

1

8

High-throughput

0.479

High

688250

KIF7
Kinesin-like protein KIF7

1

2

High-throughput

0.479

High

688251

LSM12
Protein LSM12

1

1

High-throughput

0.479

High

688254

GLE1
mRNA export factor GLE1

1

2

High-throughput

0.479

High

688255

PAN3
PAN2-PAN3 deadenylation complex subunit PAN3

1

2

High-throughput

0.479

High

688256

PRC2B
Protein PRRC2B

1

5

High-throughput

0.479

High

688259

OTUD3
OTU domain-containing protein 3

1

4

Small-scale

0.479

High

688260

TUT4
Terminal uridylyltransferase 4

1

1

High-throughput

0.479

High

688261

RC3H1
Roquin-1

1

3

High-throughput

0.479

High

688262

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

3

High-throughput

0.479

High

688266

CEP85
Centrosomal protein of 85 kDa

1

2

High-throughput

0.479

High

688267

GGYF2
GRB10-interacting GYF protein 2

1

1

High-throughput

0.479

High

688269

YTHD3
YTH domain-containing family protein 3

1

5

High-throughput

0.479

High

688270

PATL1
Protein PAT1 homolog 1

1

3

High-throughput

0.479

High

688271

ZN598
E3 ubiquitin-protein ligase ZNF598

1

4

High-throughput

0.479

High

688272

GPBP1
Vasculin

1

2

High-throughput

0.479

High

688273

MEX3D
RNA-binding protein MEX3D

1

9

High-throughput

0.479

High

688281

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

6

High-throughput

0.479

High

688282

PUM2
Pumilio homolog 2

1

4

High-throughput

0.479

High

688283

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.479

High

688284

HDAC7
Histone deacetylase 7

1

5

Small-scale

0.479

High

688286

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

688287

CNOT9
CCR4-NOT transcription complex subunit 9

1

6

High-throughput

0.479

High

688288

LAR4B
La-related protein 4B

1

1

High-throughput

0.479

High

688289

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

Small-scale

0.479

High

688290

RENT1
Regulator of nonsense transcripts 1

1

3

High-throughput

0.479

High

688291

FUBP2
Far upstream element-binding protein 2

1

12

Small-scale

0.479

High

688297

FUBP3
Far upstream element-binding protein 3

1

12

High-throughput

0.479

High

688298

ASPP1
Apoptosis-stimulating of p53 protein 1

1

2

High-throughput

0.479

High

688301

ATX2
Ataxin-2

1

4

High-throughput

0.479

High

688302

LZTS2
Leucine zipper putative tumor suppressor 2

1

1

High-throughput

0.479

High

688303

TRI56
E3 ubiquitin-protein ligase TRIM56

1

9

High-throughput

0.479

High

688306

LS14B
Protein LSM14 homolog B

1

6

High-throughput

0.479

High

688308

YTHD1
YTH domain-containing family protein 1

1

5

High-throughput

0.479

High

688309

CPEB1
Cytoplasmic polyadenylation element-binding protein 1

1

5

High-throughput

0.479

High

688310

TB182
182 kDa tankyrase-1-binding protein

1

5

High-throughput

0.479

High

688313

ESRP2
Epithelial splicing regulatory protein 2

1

7

High-throughput

0.479

High

688314

TDRD3
Tudor domain-containing protein 3

1

1

High-throughput

0.479

High

688315

CNO10
CCR4-NOT transcription complex subunit 10

1

1

High-throughput

0.479

High

688316

AGO3
Protein argonaute-3

1

5

High-throughput

0.479

High

688319

MOV10
Helicase MOV-10

1

3

High-throughput

0.479

High

688326

4ET
Eukaryotic translation initiation factor 4E transporter

1

1

High-throughput

0.479

High

688327

STAU2
Double-stranded RNA-binding protein Staufen homolog 2

1

1

High-throughput

0.479

High

688328

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

1

High-throughput

0.479

High

688330

CNOT2
CCR4-NOT transcription complex subunit 2

1

5

High-throughput

0.479

High

688331

NYNRI
Protein NYNRIN

1

2

High-throughput

0.479

High

688334

TBK1
Serine/threonine-protein kinase TBK1

1

1

High-throughput

0.479

High

688336

AGO2
Protein argonaute-2

1

5

High-throughput

0.479

High

688337

CNO11
CCR4-NOT transcription complex subunit 11

1

1

High-throughput

0.479

High

688338

AGO1
Protein argonaute-1

1

5

High-throughput

0.479

High

688341

TNR6B
Trinucleotide repeat-containing gene 6B protein

1

6

High-throughput

0.479

High

688342

SMG5
Nonsense-mediated mRNA decay factor SMG5

1

3

High-throughput

0.479

High

688343

R3HD2
R3H domain-containing protein 2

1

5

High-throughput

0.479

High

688345

PRC2C
Protein PRRC2C

1

5

High-throughput

0.479

High

688346

YTHD2
YTH domain-containing family protein 2

1

5

High-throughput

0.479

High

688347

NDK7
Nucleoside diphosphate kinase homolog 7

1

1

High-throughput

0.479

High

688350

M3K4
Mitogen-activated protein kinase kinase kinase 4

1

2

Small-scale

0.479

High

688312

DHX36
ATP-dependent DNA/RNA helicase DHX36

1

0

Small-scale

0.460

High

67616

RHG32
Rho GTPase-activating protein 32

1

0

High-throughput

0.458

High

155833

DPYL4
Dihydropyrimidinase-related protein 4

1

0

High-throughput

0.458

High

688233

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.458

High

688234

TROAP
Tastin

1

0

High-throughput

0.458

High

688244

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

688257

SMAG2
Protein Smaug homolog 2

1

0

High-throughput

0.458

High

688293

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

0

High-throughput

0.458

High

688300

SEBP2
Selenocysteine insertion sequence-binding protein 2

1

0

High-throughput

0.458

High

688304

TCHP
Trichoplein keratin filament-binding protein

1

0

High-throughput

0.458

High

688320

NCK5L
Nck-associated protein 5-like

1

0

High-throughput

0.458

High

688340

SUFU
Suppressor of fused homolog

1

0

High-throughput

0.458

High

688348

MAGD1
Melanoma-associated antigen D1

1

0

High-throughput

0.458

High

688245

SF01
Splicing factor 1

1

5

High-throughput

0.457

High

688227

F193A
Protein FAM193A

1

1

High-throughput

0.437

High

688307

K1671
Uncharacterized protein KIAA1671

1

1

High-throughput

0.437

High

688324

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

4

High-throughput

0.437

High

688264

PRR5L
Proline-rich protein 5-like

1

0

Small-scale

0.288

High

688285

JPH3
Junctophilin-3

1

0

High-throughput

0.268

Low

582370

B4GT1
Beta-1,4-galactosyltransferase 1

1

0

Small-scale

0.249

Low

688252

TTC31
Tetratricopeptide repeat protein 31

1

0

High-throughput

0.249

Low

688268

UBP54
Ubiquitin carboxyl-terminal hydrolase 54

1

0

High-throughput

0.249

Low

688280

RIBC1
RIB43A-like with coiled-coils protein 1

1

0

High-throughput

0.249

Low

688305

SYTM
Threonine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

688322

Q9HCK3
KIAA1569 protein

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025