Protein: FBX4
F-box only protein 4

Gene: FBX4, FBXO4
Organism: Homo sapiens
Interactions: 36
UniProt ID: Q9UKT5

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0000723 - telomere maintenance
GO:0004842 - ubiquitin-protein transferase activity
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992387

SKP1
S-phase kinase-associated protein 1

17

1

Small-scale

0.987

High

1112784

CUL1
Cullin-1

11

0

Small-scale

0.926

High

1202609

TNI3K
Serine/threonine-protein kinase TNNI3K

2

1

High-throughput

0.783

High

664829

CCND1
G1/S-specific cyclin-D1

6

1

Small-scale

0.739

High

1461217

FBX4
F-box only protein 4

2

0

Small-scale

0.736

High

928583

TERF1
Telomeric repeat-binding factor 1

8

0

Small-scale

0.721

High

1154959

NEDD8
Ubiquitin-like protein NEDD8

1

0

High-throughput

0.631

High

900217

FXR1
RNA-binding protein FXR1

2

1

Small-scale

0.624

High

607724

DCAM
S-adenosylmethionine decarboxylase proenzyme

2

0

High-throughput

0.602

High

1129582

ESPL1
Separin

2

0

High-throughput

0.602

High

1417326

AP1M1
AP-1 complex subunit mu-1

2

0

High-throughput

0.602

High

972116

1433E
14-3-3 protein epsilon

1

1

Small-scale

0.597

High

243259

PRKN
E3 ubiquitin-protein ligase parkin

1

0

Small-scale

0.586

High

1325533

FBXW8
F-box/WD repeat-containing protein 8

1

0

Small-scale

0.586

High

965936

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

Small-scale

0.561

High

944869

PCBP3
Poly(rC)-binding protein 3

1

1

High-throughput

0.536

High

984022

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.513

High

1083335

AP1B1
AP-1 complex subunit beta-1

1

0

High-throughput

0.513

High

883362

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

Small-scale

0.501

High

957236

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.501

High

982359

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

1

Small-scale

0.501

High

301759

WFS1
Wolframin

1

0

High-throughput

0.493

High

1096266

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

214060

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

1

Small-scale

0.479

High

462031

HS90A
Heat shock protein HSP 90-alpha

1

1

High-throughput

0.479

High

468903

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.479

High

1057031

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

Small-scale

0.479

High

414816

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

549261

CDK4
Cyclin-dependent kinase 4

1

0

Small-scale

0.458

High

789591

PPARG
Peroxisome proliferator-activated receptor gamma

1

0

Small-scale

0.458

High

1060308

MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1

1

0

Small-scale

0.458

High

1460416

HERC5
E3 ISG15--protein ligase HERC5

1

0

Small-scale

0.458

High

948029

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.279

Low

427956

ICAM1
Intercellular adhesion molecule 1

1

0

Small-scale

0.249

Low

559018

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025