Protein: ESPL1
Separin (EC 3.4.22.49) (Caspase-like protein ESPL1) (Extra spindle poles-like 1 protein) (Separase)

Gene: ESPL1
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q14674

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000212 - meiotic spindle organization
GO:0000281 - mitotic cytokinesis
GO:0003824 - catalytic activity
GO:0004197 - cysteine-type endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353814

PTTG1
Securin

9

0

Small-scale

0.925

High

994220

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

2

Small-scale

0.661

High

573825

CCNB1
G2/mitotic-specific cyclin-B1

4

0

Small-scale

0.649

High

1129568

DNJC7
DnaJ homolog subfamily C member 7

3

0

High-throughput

0.638

High

1129571

FUZZY
Protein fuzzy homolog

2

1

High-throughput

0.611

High

131063

TULP2
Tubby-related protein 2

2

0

High-throughput

0.602

High

1092961

CDC16
Cell division cycle protein 16 homolog

2

0

High-throughput

0.602

High

1129557

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.602

High

1129565

TET5A
Terminal nucleotidyltransferase 5A

2

0

High-throughput

0.602

High

1129582

FBX4
F-box only protein 4

2

0

High-throughput

0.602

High

1129577

SYIM
Isoleucine--tRNA ligase, mitochondrial

2

1

High-throughput

0.574

High

717810

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

2

2

Small-scale

0.571

High

977491

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

Small-scale

0.561

High

537164

HSP7C
Heat shock cognate 71 kDa protein

2

0

High-throughput

0.547

High

755560

TTK
Dual specificity protein kinase TTK

1

2

High-throughput

0.536

High

907429

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.536

High

1027457

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.536

High

1129572

DUS16
Dual specificity protein phosphatase 16

1

1

High-throughput

0.536

High

1129570

TCPH
T-complex protein 1 subunit eta

1

1

High-throughput

0.515

High

347023

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

1120153

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.513

High

1129548

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.513

High

1129551

CBPC6
Cytosolic carboxypeptidase 6

1

0

High-throughput

0.513

High

1129555

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1129562

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.513

High

1129569

KIF2C
Kinesin-like protein KIF2C

1

0

High-throughput

0.513

High

1129574

DRC3
Dynein regulatory complex subunit 3

1

0

High-throughput

0.513

High

1129580

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.513

High

1129587

FBX7
F-box only protein 7

1

0

High-throughput

0.513

High

238519

RAD21
Double-strand-break repair protein rad21 homolog

1

2

Small-scale

0.501

High

1129561

TRI63
E3 ubiquitin-protein ligase TRIM63

1

2

High-throughput

0.501

High

1129573

TRI55
Tripartite motif-containing protein 55

1

2

High-throughput

0.501

High

1129560

HDAC2
Histone deacetylase 2

1

0

High-throughput

0.493

High

1129558

PJA1
E3 ubiquitin-protein ligase Praja-1

1

0

High-throughput

0.480

High

1129559

RFFL
E3 ubiquitin-protein ligase rififylin

1

0

High-throughput

0.480

High

1129566

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

0

High-throughput

0.480

High

1129581

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.480

High

172816

XPO1
Exportin-1

1

1

High-throughput

0.479

High

258883

DNJA2
DnaJ homolog subfamily A member 2

1

1

High-throughput

0.479

High

605685

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

1

High-throughput

0.479

High

1052826

DUSP2
Dual specificity protein phosphatase 2

1

1

High-throughput

0.479

High

1105921

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1123626

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.479

High

1125433

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

1

High-throughput

0.479

High

1129567

DNJC2
DnaJ homolog subfamily C member 2

1

2

High-throughput

0.479

High

1129576

TRI36
E3 ubiquitin-protein ligase TRIM36

1

2

High-throughput

0.479

High

159654

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

0

High-throughput

0.458

High

345820

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

695461

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

897811

CDK9
Cyclin-dependent kinase 9

1

0

High-throughput

0.458

High

934615

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

1065695

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

0

High-throughput

0.458

High

1113112

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1129549

TPT1L
TPT1-like protein

1

0

High-throughput

0.458

High

1129556

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1129575

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

97003

E9PK12
Fuzzy planar cell polarity protein

1

1

High-throughput

0.445

High

718120

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

1

2

Small-scale

0.445

High

1129583

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

166299

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.426

High

1102162

ATM
Serine-protein kinase ATM

1

0

Small-scale

0.426

High

1129547

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

0

Small-scale

0.426

High

1010916

BAT1
b(0,+)-type amino acid transporter 1

1

1

High-throughput

0.407

High

1129550

NHSL2
NHS-like protein 2

1

1

High-throughput

0.407

High

1129579

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

3

High-throughput

0.407

High

1129584

XCT
Cystine/glutamate transporter

1

1

High-throughput

0.407

High

1129585

S27A6
Long-chain fatty acid transport protein 6

1

1

High-throughput

0.407

High

1129578

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

3

0

High-throughput

0.347

High

1129552

LYPD4
Ly6/PLAUR domain-containing protein 4

2

0

High-throughput

0.328

High

669322

ACKR3
Atypical chemokine receptor 3

1

0

High-throughput

0.279

Low

1129554

KLH34
Kelch-like protein 34

1

0

High-throughput

0.279

Low

1129563

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

0

High-throughput

0.279

Low

1129564

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

1129586

TDRKH
Tudor and KH domain-containing protein

1

0

High-throughput

0.279

Low

880921

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

124347

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

416020

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.249

Low

768195

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1129553

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025