Protein: XPA
DNA repair protein complementing XP-A cells (Xeroderma pigmentosum group A-complementing protein)

Gene: XPA
Organism: Homo sapiens
Interactions: 91
UniProt ID: P23025

Gene Ontology (top 5):
GO:0000110 - nucleotide-excision repair factor 1 complex
GO:0000715 - nucleotide-excision repair, DNA damage recognition
GO:0003684 - damaged DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

654103

XPC
DNA repair protein complementing XP-C cells

2

1

Small-scale

0.768

High

464358

ERCC1
DNA excision repair protein ERCC-1

19

2

Small-scale

0.766

High

587925

RFA2
Replication protein A 32 kDa subunit

15

2

Small-scale

0.763

High

654088

XPA
DNA repair protein complementing XP-A cells

2

3

Small-scale

0.755

High

654090

RFA1
Replication protein A 70 kDa DNA-binding subunit

12

0

Small-scale

0.727

High

654122

XPF
DNA repair endonuclease XPF

5

2

Small-scale

0.714

High

654120

NUP43
Nucleoporin Nup43

4

1

High-throughput

0.691

High

342750

HERC2
E3 ubiquitin-protein ligase HERC2

3

1

Small-scale

0.681

High

571871

TRI27
Zinc finger protein RFP

3

0

High-throughput

0.646

High

654133

NDEL1
Nuclear distribution protein nudE-like 1

3

0

High-throughput

0.646

High

654109

ATR
Serine/threonine-protein kinase ATR

2

2

Small-scale

0.624

High

611640

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.618

High

654102

PRKDC
DNA-dependent protein kinase catalytic subunit

2

2

Small-scale

0.602

High

654116

Z518A
Zinc finger protein 518A

2

0

High-throughput

0.585

High

171054

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.580

High

180236

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

555453

SKIL
Ski-like protein

2

0

High-throughput

0.580

High

633595

PSB1
Proteasome subunit beta type-1

2

0

High-throughput

0.580

High

654119

ZN655
Zinc finger protein 655

2

0

High-throughput

0.580

High

654123

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.580

High

654132

ARI3A
AT-rich interactive domain-containing protein 3A

2

0

High-throughput

0.580

High

654137

PICK1
PRKCA-binding protein

2

0

High-throughput

0.580

High

654139

TBCD7
TBC1 domain family member 7

2

0

High-throughput

0.580

High

654094

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.576

High

654108

TOP3A
DNA topoisomerase 3-alpha

2

0

High-throughput

0.576

High

654143

KLH21
Kelch-like protein 21

2

0

High-throughput

0.576

High

654104

ERCC6
DNA excision repair protein ERCC-6

2

0

Small-scale

0.569

High

654121

DDB2
DNA damage-binding protein 2

1

1

Small-scale

0.561

High

224084

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.541

High

373774

RASN
GTPase NRas

1

1

High-throughput

0.541

High

654096

MLH1
DNA mismatch repair protein Mlh1

1

2

High-throughput

0.541

High

654101

PMS2
Mismatch repair endonuclease PMS2

1

2

High-throughput

0.541

High

654141

MLH3
DNA mismatch repair protein Mlh3

1

2

High-throughput

0.541

High

550842

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

654144

CE164
Centrosomal protein of 164 kDa

1

0

Small-scale

0.537

High

284541

ECI2
Enoyl-CoA delta isomerase 2

1

2

High-throughput

0.536

High

654100

CDK7
Cyclin-dependent kinase 7

1

1

High-throughput

0.536

High

654126

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

0

Small-scale

0.530

High

654136

SYF1
Pre-mRNA-splicing factor SYF1

1

0

Small-scale

0.529

High

654106

RFA4
Replication protein A 30 kDa subunit

1

2

Small-scale

0.527

High

169950

AURKA
Aurora kinase A

1

0

High-throughput

0.518

High

442590

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.518

High

557096

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.518

High

654095

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

High-throughput

0.518

High

654113

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.518

High

654114

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

654124

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.518

High

654130

RHG07
Rho GTPase-activating protein 7

1

0

High-throughput

0.518

High

654142

MUTYH
Adenine DNA glycosylase

1

0

High-throughput

0.518

High

654117

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

132432

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

226956

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

249569

SNX3
Sorting nexin-3

1

0

High-throughput

0.513

High

256581

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

0

High-throughput

0.513

High

633290

MSH3
DNA mismatch repair protein Msh3

1

2

Small-scale

0.501

High

654097

MSH2
DNA mismatch repair protein Msh2

1

2

Small-scale

0.501

High

654107

ATM
Serine-protein kinase ATM

1

2

Small-scale

0.501

High

654118

RHOU
Rho-related GTP-binding protein RhoU

1

2

High-throughput

0.501

High

595940

H12
Histone H1.2

1

0

High-throughput

0.493

High

654135

GPN1
GPN-loop GTPase 1

1

0

Small-scale

0.486

High

654099

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

654092

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.480

High

654115

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.480

High

172477

XPO1
Exportin-1

1

1

High-throughput

0.479

High

334999

ARI2
E3 ubiquitin-protein ligase ARIH2

1

1

High-throughput

0.479

High

654089

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

2

Small-scale

0.479

High

654093

TF2H1
General transcription factor IIH subunit 1

1

1

Small-scale

0.479

High

654129

SNX27
Sorting nexin-27

1

2

High-throughput

0.479

High

654140

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

654134

PRD16
Histone-lysine N-methyltransferase PRDM16

1

0

High-throughput

0.460

High

259447

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

386439

SPTA1
Spectrin alpha chain, erythrocytic 1

1

0

Small-scale

0.458

High

481091

HMGB1
High mobility group protein B1

1

0

Small-scale

0.458

High

583996

FOSL1
Fos-related antigen 1

1

0

Small-scale

0.458

High

606229

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

654105

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.458

High

654111

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

339938

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

2

High-throughput

0.445

High

190818

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.438

High

654138

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.438

High

654098

RAD52
DNA repair protein RAD52 homolog

1

0

High-throughput

0.426

High

654110

WRN
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN

1

0

High-throughput

0.426

High

654145

NISCH
Nischarin

1

0

High-throughput

0.426

High

177088

SNPH
Syntaphilin

2

0

High-throughput

0.316

High

654112

PGFRL
Platelet-derived growth factor receptor-like protein

1

0

High-throughput

0.282

High

654091

S10A2
Protein S100-A2

1

0

High-throughput

0.279

Low

654125

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.279

Low

654127

HMCES
Abasic site processing protein HMCES

1

0

High-throughput

0.279

Low

654128

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.279

Low

654131

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025