Protein: SGMR1
Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)

Gene: SGMR1, SIGMAR1
Organism: Homo sapiens
Interactions: 141
UniProt ID: Q99720

Gene Ontology (top 5):
GO:0004985 - G protein-coupled opioid receptor activity
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005640 - nuclear outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1406714

SGMR1
Sigma non-opioid intracellular receptor 1

2

1

Small-scale

0.820

High

178371

NPC1
NPC intracellular cholesterol transporter 1

3

1

High-throughput

0.650

High

1316356

AGRG5
Adhesion G-protein coupled receptor G5

3

0

High-throughput

0.634

High

1163603

RTN1
Reticulon-1

2

1

High-throughput

0.628

High

1391913

RN185
E3 ubiquitin-protein ligase RNF185

3

0

Small-scale

0.628

High

956991

CXCR4
C-X-C chemokine receptor type 4

2

6

High-throughput

0.601

High

1312976

S35F2
Solute carrier family 35 member F2

2

3

High-throughput

0.601

High

1369554

GHSR
Growth hormone secretagogue receptor type 1

1

3

Small-scale

0.561

High

564274

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.547

High

1204217

PDZ11
PDZ domain-containing protein 11

1

1

High-throughput

0.541

High

141858

ACKR2
Atypical chemokine receptor 2

1

5

High-throughput

0.536

High

178572

PLCB
1-acyl-sn-glycerol-3-phosphate acyltransferase beta

1

1

High-throughput

0.536

High

182746

GP182
G-protein coupled receptor 182

1

7

High-throughput

0.536

High

252626

TSN2
Tetraspanin-2

1

2

High-throughput

0.536

High

328985

RTN3
Reticulon-3

1

1

High-throughput

0.536

High

349545

TSN15
Tetraspanin-15

1

1

High-throughput

0.536

High

538669

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

1

High-throughput

0.536

High

669056

FPR2
N-formyl peptide receptor 2

1

7

High-throughput

0.536

High

709276

AA2BR
Adenosine receptor A2b

1

4

High-throughput

0.536

High

762156

CNR2
Cannabinoid receptor 2

1

5

Small-scale

0.536

High

1333766

TM87A
Transmembrane protein 87A

1

1

High-throughput

0.536

High

1366197

LPAR1
Lysophosphatidic acid receptor 1

1

5

High-throughput

0.536

High

1406715

CML1
Chemerin-like receptor 1

1

7

High-throughput

0.536

High

1406716

TM208
Transmembrane protein 208

1

1

High-throughput

0.536

High

1406727

PLCC
1-acyl-sn-glycerol-3-phosphate acyltransferase gamma

1

1

High-throughput

0.536

High

1406737

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

3

High-throughput

0.536

High

422971

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.530

High

49749

TMM72
Transmembrane protein 72

1

0

High-throughput

0.513

High

125047

KCNK1
Potassium channel subfamily K member 1

1

0

High-throughput

0.513

High

180578

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.513

High

184218

RER1
Protein RER1

1

0

High-throughput

0.513

High

270475

FZD7
Frizzled-7

1

0

High-throughput

0.513

High

297255

PRAF3
PRA1 family protein 3

1

0

High-throughput

0.513

High

336569

PIGN
GPI ethanolamine phosphate transferase 1

1

0

High-throughput

0.513

High

341469

CDS2
Phosphatidate cytidylyltransferase 2

1

0

High-throughput

0.513

High

420039

B3A2
Anion exchange protein 2

1

0

High-throughput

0.513

High

665008

ERD21
ER lumen protein-retaining receptor 1

1

0

High-throughput

0.513

High

690360

STOM
Stomatin

1

0

High-throughput

0.513

High

701426

5HT1B
5-hydroxytryptamine receptor 1B

1

0

High-throughput

0.513

High

1086093

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

1101185

CLN3
Battenin

1

0

High-throughput

0.513

High

1147829

DHC24
Delta(24)-sterol reductase

1

0

High-throughput

0.513

High

1187414

SHSL1
Protein shisa-like-1

1

0

High-throughput

0.513

High

1256848

GOT1A
Vesicle transport protein GOT1A

1

0

High-throughput

0.513

High

1291470

RETR3
Reticulophagy regulator 3

1

0

High-throughput

0.513

High

1310338

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1325906

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

1350047

SPP2B
Signal peptide peptidase-like 2B

1

0

High-throughput

0.513

High

1402490

SERC2
Serine incorporator 2

1

0

High-throughput

0.513

High

1406717

TMPSD
Transmembrane protease serine 13

1

0

High-throughput

0.513

High

1406722

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

1406723

VEZA
Vezatin

1

0

High-throughput

0.513

High

1406724

SAYS1
SAYSvFN domain-containing protein 1

1

0

High-throughput

0.513

High

1406730

GPC5B
G-protein coupled receptor family C group 5 member B

1

0

High-throughput

0.513

High

1406731

GCP4
Gamma-tubulin complex component 4

1

0

High-throughput

0.513

High

721166

SORCN
Sorcin

1

0

Small-scale

0.494

High

1366713

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

0

High-throughput

0.493

High

127174

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.493

High

605795

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

0

High-throughput

0.493

High

789003

TGFR2
TGF-beta receptor type-2

1

0

High-throughput

0.493

High

895640

SERPH
Serpin H1

1

0

High-throughput

0.493

High

351950

S1PR4
Sphingosine 1-phosphate receptor 4

1

6

High-throughput

0.489

High

477458

CD63
CD63 antigen

1

1

High-throughput

0.489

High

640454

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

6

High-throughput

0.489

High

669243

NK1R
Substance-P receptor

1

3

High-throughput

0.489

High

733422

CCR1
C-C chemokine receptor type 1

1

5

High-throughput

0.489

High

771217

APJ
Apelin receptor

1

5

High-throughput

0.489

High

1101640

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.489

High

1205024

RABL3
Rab-like protein 3

1

1

High-throughput

0.489

High

1291875

P2RY8
S-geranylgeranyl-glutathione receptor P2RY8

1

6

High-throughput

0.489

High

1406726

GPR84
G-protein coupled receptor 84

1

2

High-throughput

0.489

High

1406728

GP173
Probable G-protein coupled receptor 173

1

2

High-throughput

0.489

High

1406736

GPR52
G-protein coupled receptor 52

1

3

High-throughput

0.489

High

1406738

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

770907

OPRM
Mu-type opioid receptor

1

4

Small-scale

0.479

High

1088787

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

2

Small-scale

0.479

High

1098534

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

2

Small-scale

0.479

High

1128463

ITPR3
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR3

1

1

Small-scale

0.479

High

1359350

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

1

1

High-throughput

0.479

High

1406733

S12A6
Solute carrier family 12 member 6

1

2

Small-scale

0.479

High

537776

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

598185

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

0

Small-scale

0.458

High

831306

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

947263

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

0

High-throughput

0.458

High

1006096

DLG4
Disks large homolog 4

1

0

Small-scale

0.458

High

1030680

ANK2
Ankyrin-2

1

0

Small-scale

0.458

High

1229647

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1249152

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1333970

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.458

High

1356228

RN139
E3 ubiquitin-protein ligase RNF139

1

0

High-throughput

0.458

High

1406315

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.458

High

189991

MOT7
Monocarboxylate transporter 7

1

1

High-throughput

0.445

High

256123

S19A2
Thiamine transporter 1

1

1

High-throughput

0.445

High

538803

GTR2
Solute carrier family 2, facilitated glucose transporter member 2

1

1

High-throughput

0.445

High

720398

SC6A1
Sodium- and chloride-dependent GABA transporter 1

1

3

High-throughput

0.445

High

722590

CTR1
High affinity cationic amino acid transporter 1

1

3

High-throughput

0.445

High

869659

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

3

High-throughput

0.445

High

870295

S6A12
Sodium- and chloride-dependent betaine transporter

1

3

High-throughput

0.445

High

1179023

S35G1
Solute carrier family 35 member G1

1

4

High-throughput

0.445

High

1218856

GP107
Protein GPR107

1

1

High-throughput

0.445

High

1291762

S22AG
Solute carrier family 22 member 16

1

2

High-throughput

0.445

High

1324753

S35F6
Solute carrier family 35 member F6

1

2

High-throughput

0.445

High

1348626

S7A14
Solute carrier family 7 member 14

1

3

High-throughput

0.445

High

1350590

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

2

High-throughput

0.445

High

1357826

S35F5
Solute carrier family 35 member F5

1

3

High-throughput

0.445

High

1406718

S19A3
Thiamine transporter 2

1

1

High-throughput

0.445

High

1068887

NIPA4
Magnesium transporter NIPA4

1

0

High-throughput

0.426

High

1236289

MFSD5
Molybdate-anion transporter

1

0

High-throughput

0.426

High

1406735

S45A2
Membrane-associated transporter protein

1

0

High-throughput

0.426

High

1211952

S35F1
Solute carrier family 35 member F1

1

4

High-throughput

0.407

High

1308949

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

1326974

SVOP
Synaptic vesicle 2-related protein

1

2

High-throughput

0.407

High

1361295

CTR3
Cationic amino acid transporter 3

1

4

High-throughput

0.407

High

1406732

NPCL1
NPC1-like intracellular cholesterol transporter 1

1

1

High-throughput

0.407

High

1406734

YLAT1
Y+L amino acid transporter 1

1

3

High-throughput

0.407

High

1028117

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

0

Small-scale

0.292

High

190563

COPT2
Protein SLC31A2

1

0

High-throughput

0.279

Low

320490

TM63A
Mechanosensitive cation channel TMEM63A

1

0

High-throughput

0.279

Low

733059

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

1251679

T184A
Transmembrane protein 184A

1

0

High-throughput

0.279

Low

1333417

S43A3
Equilibrative nucleobase transporter 1

1

0

High-throughput

0.279

Low

1361353

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1406719

YIPF3
Protein YIPF3

1

0

High-throughput

0.279

Low

218680

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

299681

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.249

Low

589507

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696320

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768990

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1005019

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1086479

KCNH2
Voltage-gated inwardly rectifying potassium channel KCNH2

1

0

Small-scale

0.249

Low

1238791

TECT3
Tectonic-3

1

0

High-throughput

0.249

Low

1255228

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1348186

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1406721

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1406729

T106B
Transmembrane protein 106B

1

0

High-throughput

0.249

Low

754084

CD80
T-lymphocyte activation antigen CD80

1

0

High-throughput

0.232

Low

1134155

NTCP
Hepatic sodium/bile acid cotransporter

1

0

High-throughput

0.232

Low

1157194

S15A2
Solute carrier family 15 member 2

1

0

High-throughput

0.232

Low

1406720

MFSD1
Lysosomal dipeptide transporter MFSD1

1

0

High-throughput

0.232

Low

1406725

S35C2
Solute carrier family 35 member C2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025