Protein: DBHA
DNA-binding protein HU-alpha (HU-2) (NS2)

Gene: DBHA, hupA
Organism: Escherichia coli K-12
Interactions: 112
UniProt ID: P0ACF0

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005829 - cytosol
GO:0006270 - DNA replication initiation
GO:0006281 - DNA repair
GO:0006351 - DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

499045

DBHB
DNA-binding protein HU-beta

5

13

Small-scale

0.932

High

499044

DBHA
DNA-binding protein HU-alpha

1

13

Small-scale

0.692

High

395077

DNAA
Chromosomal replication initiator protein DnaA

3

0

Small-scale

0.627

High

490960

IHFB
Integration host factor subunit beta

1

13

High-throughput

0.625

High

491066

DNAK
Chaperone protein DnaK

2

2

High-throughput

0.612

High

495327

UVRB
UvrABC system protein B

2

3

High-throughput

0.588

High

495811

RPOC
DNA-directed RNA polymerase subunit beta'

2

1

High-throughput

0.588

High

496281

CSPE
Cold shock-like protein CspE

2

5

High-throughput

0.588

High

496760

SLYD
FKBP-type peptidyl-prolyl cis-trans isomerase SlyD

2

2

High-throughput

0.588

High

497377

CSPA
Cold shock protein CspA

2

5

High-throughput

0.588

High

497404

CSPC
Cold shock-like protein CspC

2

5

High-throughput

0.588

High

497615

RLUC
Ribosomal large subunit pseudouridine synthase C

2

4

High-throughput

0.588

High

497981

YBCJ
Putative RNA-binding protein YbcJ

2

2

High-throughput

0.588

High

499046

HNS
DNA-binding protein H-NS

2

1

High-throughput

0.588

High

499048

ALLR
HTH-type transcriptional repressor AllR

2

2

High-throughput

0.588

High

499061

YFIF
Uncharacterized tRNA/rRNA methyltransferase YfiF

2

1

High-throughput

0.588

High

499064

TOP3
DNA topoisomerase 3

2

2

High-throughput

0.588

High

499070

RNR
Ribonuclease R

2

1

High-throughput

0.588

High

499090

NFI
Endonuclease V

2

3

High-throughput

0.588

High

499093

YBJX
Uncharacterized protein YbjX

2

1

High-throughput

0.588

High

495353

UVRC
UvrABC system protein C

2

0

High-throughput

0.576

High

432417

T1SK
Type I restriction enzyme EcoKI specificity subunit

2

1

High-throughput

0.571

High

499053

FKBX
FKBP-type 16 kDa peptidyl-prolyl cis-trans isomerase

2

2

High-throughput

0.571

High

421115

PNP
Polyribonucleotide nucleotidyltransferase

2

0

High-throughput

0.563

High

491542

KDSA
2-dehydro-3-deoxyphosphooctonate aldolase

2

0

High-throughput

0.563

High

495897

RPOB
DNA-directed RNA polymerase subunit beta

2

0

High-throughput

0.563

High

499059

SPOT
Bifunctional

2

0

High-throughput

0.563

High

491932

RPPH
RNA pyrophosphohydrolase

2

1

High-throughput

0.537

High

494067

RS4
Small ribosomal subunit protein uS4

1

3

High-throughput

0.536

High

499086

RL2
Large ribosomal subunit protein uL2

1

2

High-throughput

0.536

High

499087

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.536

High

456992

CHEA
Chemotaxis protein CheA

1

0

High-throughput

0.513

High

499067

PHNN
Ribose 1,5-bisphosphate phosphokinase PhnN

1

0

High-throughput

0.513

High

499094

BLUR
HTH-type transcriptional repressor BluR

1

0

High-throughput

0.513

High

393924

PBPB
Penicillin-binding protein 1B

1

2

High-throughput

0.500

High

498635

EXBB
Biopolymer transport protein ExbB

1

1

High-throughput

0.500

High

499047

ROB
Right origin-binding protein

1

2

High-throughput

0.500

High

384021

RL15
Large ribosomal subunit protein uL15

1

1

High-throughput

0.489

High

361747

PHSM
Maltodextrin phosphorylase

1

1

High-throughput

0.484

High

365872

DPO1
DNA polymerase I

1

1

High-throughput

0.484

High

395152

UVRD
DNA helicase II

1

2

High-throughput

0.484

High

444294

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.484

High

450094

RF2
Peptide chain release factor RF2

1

1

High-throughput

0.484

High

490703

FIS
DNA-binding protein Fis

1

1

High-throughput

0.484

High

490877

HFQ
RNA-binding protein Hfq

1

1

High-throughput

0.484

High

492232

PYRH
Uridylate kinase

1

1

High-throughput

0.484

High

494607

RPOA
DNA-directed RNA polymerase subunit alpha

1

1

High-throughput

0.484

High

494788

SSRP
SsrA-binding protein

1

1

High-throughput

0.484

High

494883

TGT
Queuine tRNA-ribosyltransferase

1

1

High-throughput

0.484

High

496256

CSPD
Cold shock-like protein CspD

1

5

High-throughput

0.484

High

497078

DEAD
ATP-dependent RNA helicase DeaD

1

3

High-throughput

0.484

High

499066

MALQ
4-alpha-glucanotransferase

1

1

High-throughput

0.484

High

499072

MNME
tRNA modification GTPase MnmE

1

1

High-throughput

0.484

High

499082

RLUB
Ribosomal large subunit pseudouridine synthase B

1

4

High-throughput

0.484

High

499071

MAK
Fructokinase

1

0

High-throughput

0.479

High

499074

OTSA
Trehalose-6-phosphate synthase

1

0

High-throughput

0.479

High

499088

YPFJ
Uncharacterized protein YpfJ

1

0

High-throughput

0.479

High

499089

YQJI
Transcriptional regulator YqjI

1

0

High-throughput

0.479

High

492267

QUEA
S-adenosylmethionine:tRNA ribosyltransferase-isomerase

1

1

High-throughput

0.479

High

495559

TMAR
Pole-localizer protein TmaR

1

2

High-throughput

0.479

High

496873

P5CR
Pyrroline-5-carboxylate reductase

1

1

High-throughput

0.479

High

497483

RL13
Large ribosomal subunit protein uL13

1

1

High-throughput

0.479

High

498965

HEM2
Delta-aminolevulinic acid dehydratase

1

1

High-throughput

0.479

High

499050

KPYK1
Pyruvate kinase I

1

1

High-throughput

0.479

High

499062

ISCR
HTH-type transcriptional regulator IscR

1

2

High-throughput

0.479

High

499091

CSRA
Carbon storage regulator

1

1

High-throughput

0.479

High

499095

YNCE
Uncharacterized protein YncE

1

1

High-throughput

0.479

High

499096

KDGR
HTH-type transcriptional regulator KdgR

1

2

High-throughput

0.479

High

490642

FABA
3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase

1

0

High-throughput

0.464

High

496719

PHOL
PhoH-like protein

1

0

High-throughput

0.464

High

499057

ATL
DNA base-flipping protein

1

0

High-throughput

0.464

High

499063

RCSA
Transcriptional regulatory protein RcsA

1

0

High-throughput

0.464

High

499078

RLMN
Dual-specificity RNA methyltransferase RlmN

1

0

High-throughput

0.464

High

483706

PUTA
Bifunctional protein PutA [Includes: Proline dehydrogenase

1

0

High-throughput

0.458

High

490741

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(P)+]

1

0

High-throughput

0.458

High

495967

YFBU
UPF0304 protein YfbU

1

0

High-throughput

0.458

High

496053

BLC
Outer membrane lipoprotein Blc

1

0

High-throughput

0.458

High

499054

GLNP
Glutamine transport system permease protein GlnP

1

0

High-throughput

0.458

High

499068

CIRA
Colicin I receptor

1

0

High-throughput

0.458

High

499077

NIKB
Nickel transport system permease protein NikB

1

0

High-throughput

0.458

High

499079

ZNTA
Zinc/cadmium/lead-transporting P-type ATPase

1

0

High-throughput

0.458

High

499085

YJJU
Uncharacterized protein YjjU

1

0

High-throughput

0.458

High

499058

YBBO
Uncharacterized oxidoreductase YbbO

1

2

High-throughput

0.457

High

499065

SRLR
Glucitol operon repressor

1

2

High-throughput

0.442

High

393875

PBPA
Penicillin-binding protein 1A

1

2

High-throughput

0.437

High

432124

APAH
Bis(5'-nucleosyl)-tetraphosphatase [symmetrical]

1

1

High-throughput

0.437

High

499052

RL23
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

499083

AG43
Antigen 43

1

1

High-throughput

0.437

High

499092

RLMF
Ribosomal RNA large subunit methyltransferase F

1

1

High-throughput

0.437

High

499060

SSB
Single-stranded DNA-binding protein

1

0

High-throughput

0.426

High

499075

INTA
Prophage integrase IntA

1

0

High-throughput

0.426

High

494561

RNPA
Ribonuclease P protein component

2

0

High-throughput

0.313

High

494544

RNH
Ribonuclease HI

2

0

High-throughput

0.307

High

469365

YCIH
Uncharacterized protein YciH

1

0

High-throughput

0.279

Low

491893

NRDI
Protein NrdI

1

0

High-throughput

0.279

Low

499098

OMPL
Porin OmpL

1

0

High-throughput

0.279

Low

499055

YJDI
Uncharacterized protein YjdI

1

0

High-throughput

0.269

Low

499069

MURG
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

1

0

High-throughput

0.253

Low

499073

RIBD
Riboflavin biosynthesis protein RibD [Includes: Diaminohydroxyphosphoribosylaminopyrimidine deaminase

1

0

High-throughput

0.253

Low

499076

DUSC
tRNA-dihydrouridine(16) synthase

1

0

High-throughput

0.253

Low

495755

YCJF
UPF0283 membrane protein YcjF

1

0

High-throughput

0.249

Low

498424

CYOC
Cytochrome bo(3) ubiquinol oxidase subunit 3

1

0

High-throughput

0.249

Low

499049

LAPA
Lipopolysaccharide assembly protein A

1

0

High-throughput

0.249

Low

499051

NLPD
Murein hydrolase activator NlpD

1

0

High-throughput

0.249

Low

499056

OXC
Oxalyl-CoA decarboxylase

1

0

High-throughput

0.249

Low

499080

YHJD
Inner membrane protein YhjD

1

0

High-throughput

0.249

Low

499081

WBBK
Putative glycosyltransferase WbbK

1

0

High-throughput

0.249

Low

499084

YJIN
Uncharacterized protein YjiN

1

0

High-throughput

0.249

Low

499097

5DNU
5'-deoxynucleotidase YfbR

1

0

High-throughput

0.249

Low

499099

ASTC
Succinylornithine transaminase

1

0

High-throughput

0.249

Low

499100

UACF
Putative oxidoreductase UacF

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025