Protein: TFB4
General transcription and DNA repair factor IIH subunit TFB4 (TFIIH subunit TFB4) (RNA polymerase II transcription factor B 34 kDa subunit) (RNA polymerase II transcription factor B p34 subunit) (RNA polymerase II transcription factor B subunit 4)

Gene: TFB4
Organism: Saccharomyces cerevisiae S288C
Interactions: 64
UniProt ID: Q12004

Gene Ontology (top 5):
GO:0000112 - nucleotide-excision repair factor 3 complex
GO:0000439 - transcription factor TFIIH core complex
GO:0005675 - transcription factor TFIIH holo complex
GO:0006289 - nucleotide-excision repair
GO:0006355 - regulation of DNA-templated transcription

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1047342

SSL1
General transcription and DNA repair factor IIH subunit SSL1

10

3

Small-scale

0.973

High

1039905

TFB2
General transcription and DNA repair factor IIH subunit TFB2

6

2

Small-scale

0.941

High

744630

TFB1
General transcription and DNA repair factor IIH subunit TFB1

10

1

Small-scale

0.757

High

1042304

TFB3
RNA polymerase II transcription factor B subunit 3

6

1

Small-scale

0.722

High

449369

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD/RAD3

5

2

Small-scale

0.709

High

1025786

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

4

1

Small-scale

0.680

High

1084088

TFB5
General transcription and DNA repair factor IIH subunit TFB5

4

0

Small-scale

0.649

High

790522

CCL1
Cyclin CCL1

4

0

Small-scale

0.644

High

440868

KIN28
Serine/threonine-protein kinase KIN28

3

1

Small-scale

0.643

High

580212

HSC82
ATP-dependent molecular chaperone HSC82

2

2

Small-scale

0.558

High

525448

HSP71
Heat shock protein SSA1

2

1

Small-scale

0.549

High

546628

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

Small-scale

0.549

High

820044

SSB2
Ribosome-associated molecular chaperone SSB2

2

1

Small-scale

0.549

High

547894

NHP6B
Non-histone chromosomal protein 6B

1

1

Small-scale

0.527

High

676447

MAS5
Mitochondrial protein import protein MAS5

1

0

Small-scale

0.513

High

393487

HSP82
ATP-dependent molecular chaperone HSP82

1

2

Small-scale

0.489

High

527939

HSP72
Heat shock protein SSA2

1

1

Small-scale

0.489

High

742608

HSP7F
Heat shock protein homolog SSE1

1

2

Small-scale

0.489

High

408445

GAL4
Regulatory protein GAL4

1

0

Small-scale

0.460

High

489012

SWI6
Regulatory protein SWI6

1

0

High-throughput

0.458

High

594618

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

359081

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

1

Small-scale

0.457

High

359369

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

1

Small-scale

0.457

High

381302

H2B1
Histone H2B.1

1

1

High-throughput

0.445

High

781069

T2EA
Transcription initiation factor IIE subunit alpha

1

1

Small-scale

0.445

High

547836

NHP6A
Non-histone chromosomal protein 6A

1

1

Small-scale

0.439

High

402143

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.426

High

572664

ALF
Fructose-bisphosphate aldolase

1

0

Small-scale

0.426

High

655645

TAF2
Transcription initiation factor TFIID subunit 2

1

0

Small-scale

0.426

High

708454

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.426

High

740438

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.426

High

763389

TAF14
Transcription initiation factor TFIID subunit 14

1

0

Small-scale

0.426

High

782151

T2EB
Transcription initiation factor IIE subunit beta

1

0

Small-scale

0.426

High

836541

T2FA
Transcription initiation factor IIF subunit alpha

1

0

Small-scale

0.426

High

836561

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.426

High

948685

ACT
Actin

1

0

Small-scale

0.426

High

1035345

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

1

High-throughput

0.407

High

1084086

CAF1A
Chromatin assembly factor 1 subunit A

1

1

High-throughput

0.407

High

581910

SYKC
Lysine--tRNA ligase, cytoplasmic

2

0

High-throughput

0.324

High

590745

HSP26
Heat shock protein 26

2

0

High-throughput

0.307

High

510889

HSP77
Import motor subunit, mitochondrial

1

0

Small-scale

0.279

Low

621414

METK2
S-adenosylmethionine synthase 2

1

0

Small-scale

0.279

Low

776666

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.279

Low

792489

CDC27
Anaphase-promoting complex subunit CDC27

1

0

High-throughput

0.279

Low

365217

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.261

Low

394987

EF1A
Elongation factor 1-alpha

1

0

Small-scale

0.261

Low

592557

VATB
V-type proton ATPase subunit B

1

0

Small-scale

0.261

Low

626914

HSP60
Heat shock protein 60, mitochondrial

1

0

Small-scale

0.261

Low

734227

EF2
Elongation factor 2

1

0

Small-scale

0.261

Low

734744

IMB3
Importin subunit beta-3

1

0

Small-scale

0.261

Low

836944

MPG1
Mannose-1-phosphate guanyltransferase

1

0

Small-scale

0.261

Low

1084087

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.251

Low

672738

BPH1
Beige protein homolog 1

1

0

High-throughput

0.249

Low

741168

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

0

High-throughput

0.249

Low

803059

MUP3
Low-affinity methionine permease

1

0

High-throughput

0.249

Low

1062339

YO036
Uncharacterized protein YOL036W

1

0

High-throughput

0.249

Low

1065526

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

561543

TBP
TATA-box-binding protein

1

0

Small-scale

0.232

Low

740477

MED22
Mediator of RNA polymerase II transcription subunit 22

1

0

Small-scale

0.232

Low

740817

MED18
Mediator of RNA polymerase II transcription subunit 18

1

0

Small-scale

0.232

Low

753638

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.232

Low

757598

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

Small-scale

0.232

Low

805367

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

Small-scale

0.232

Low

805873

ARO9
Aromatic amino acid aminotransferase 2

1

0

Small-scale

0.232

Low


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Last updated: 11Aug2025