Protein: AFT1
Iron-regulated transcriptional activator AFT1 (Activator of iron transcription protein 1)

Gene: AFT1
Organism: Saccharomyces cerevisiae S288C
Interactions: 89
UniProt ID: P22149

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

645640

GLRX3
Monothiol glutaredoxin-3

7

2

Small-scale

0.748

High

645602

GLRX4
Monothiol glutaredoxin-4

5

2

Small-scale

0.724

High

645610

CENPL
Inner kinetochore subunit IML3

3

0

Small-scale

0.621

High

645586

AFT1
Iron-regulated transcriptional activator AFT1

2

1

Small-scale

0.614

High

547762

NHP6A
Non-histone chromosomal protein 6A

2

0

Small-scale

0.603

High

575269

RAD9
DNA repair protein RAD9

1

0

Small-scale

0.537

High

577526

CYC8
General transcriptional corepressor CYC8

1

0

Small-scale

0.537

High

645597

HOG1
Mitogen-activated protein kinase HOG1

1

0

Small-scale

0.537

High

645621

MSN5
Protein MSN5

1

0

Small-scale

0.529

High

645638

GCN5
Histone acetyltransferase GCN5

1

0

High-throughput

0.513

High

645615

YAP5
AP-1-like transcription factor YAP5

1

0

High-throughput

0.486

High

645628

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.486

High

645596

IMB3
Importin subunit beta-3

1

0

Small-scale

0.480

High

645592

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

645635

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

1

Small-scale

0.479

High

601992

CBF1
Centromere-binding protein 1

1

0

Small-scale

0.460

High

645622

NBP35
Cytosolic Fe-S cluster assembly factor NBP35

1

0

Small-scale

0.460

High

645653

NBP2
NAP1-binding protein 2

1

0

High-throughput

0.460

High

624866

MED15
Mediator of RNA polymerase II transcription subunit 15

1

0

Small-scale

0.458

High

645606

MAC1
Metal-binding activator 1

1

0

Small-scale

0.458

High

645607

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

645611

CENPN
Inner kinetochore subunit CHL4

1

0

Small-scale

0.458

High

645637

CENPP
Inner kinetochore subunit CTF19

1

0

Small-scale

0.458

High

645642

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

645650

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

645652

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.458

High

645645

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

1

High-throughput

0.457

High

523075

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

525937

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

543833

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

643601

SNF2
Transcription regulatory protein SNF2

1

2

High-throughput

0.445

High

645588

MCM3
DNA replication licensing factor MCM3

1

2

High-throughput

0.445

High

645591

RSC6
Chromatin structure-remodeling complex protein RSC6

1

1

High-throughput

0.445

High

645593

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.445

High

645594

MCM5
Minichromosome maintenance protein 5

1

2

High-throughput

0.445

High

645595

BTAF1
TATA-binding protein-associated factor MOT1

1

3

High-throughput

0.445

High

645599

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

645600

SWI3
SWI/SNF complex subunit SWI3

1

2

High-throughput

0.445

High

645601

STH1
Nuclear protein STH1/NPS1

1

2

High-throughput

0.445

High

645604

RSC7
Chromatin structure-remodeling complex subunit RSC7

1

1

High-throughput

0.445

High

645605

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.445

High

645609

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

1

High-throughput

0.445

High

645616

SWP82
SWI/SNF global transcription activator complex subunit SWP82

1

1

High-throughput

0.445

High

645617

RSC8
Chromatin structure-remodeling complex protein RSC8

1

2

High-throughput

0.445

High

645624

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.445

High

645625

INO80
Chromatin-remodeling ATPase INO80

1

1

High-throughput

0.445

High

645630

SNF12
Transcription regulatory protein SNF12

1

1

High-throughput

0.445

High

645636

ADA2
SAGA complex subunit ADA2

1

2

High-throughput

0.445

High

645641

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.445

High

645644

ARP9
Actin-like protein ARP9

1

1

High-throughput

0.445

High

645648

RSC2
Chromatin structure-remodeling complex subunit RSC2

1

3

High-throughput

0.445

High

645654

ARP8
Actin-like protein ARP8

1

1

High-throughput

0.445

High

645655

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.445

High

645656

H2AZ
Histone H2A.Z

1

1

High-throughput

0.445

High

645643

MYO5
Myosin-5

1

0

High-throughput

0.438

High

381404

H2B2
Histone H2B.2

1

0

High-throughput

0.426

High

381876

H4
Histone H4

1

0

High-throughput

0.426

High

419600

H2A2
Histone H2A.2

1

0

High-throughput

0.426

High

449438

SPT3
SAGA complex subunit SPT3

1

0

High-throughput

0.426

High

483750

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

High-throughput

0.426

High

561418

TBP
TATA-box-binding protein

1

0

High-throughput

0.426

High

614796

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

High-throughput

0.426

High

619400

MED14
Mediator of RNA polymerase II transcription subunit 14

1

0

High-throughput

0.426

High

645587

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.426

High

645589

SIS1
Protein SIS1

1

0

High-throughput

0.426

High

645590

SGF29
SAGA complex subunit SGF29

1

0

High-throughput

0.426

High

645598

NGG1
SAGA complex subunit NGG1

1

0

High-throughput

0.426

High

645608

TAF5
SAGA complex/transcription factor TFIID complex subunit TAF5

1

0

High-throughput

0.426

High

645612

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.426

High

645614

MET18
DNA repair/transcription protein MET18/MMS19

1

0

High-throughput

0.426

High

645619

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.426

High

645620

SPT20
SAGA complex subunit SPT20

1

0

High-throughput

0.426

High

645623

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.426

High

645626

SGF73
SAGA complex subunit SGF73

1

0

High-throughput

0.426

High

645627

ENV11
Late endosome and vacuole interface protein 11

1

0

High-throughput

0.426

High

645629

H1
Histone H1

1

0

High-throughput

0.426

High

645631

ACT
Actin

1

0

High-throughput

0.426

High

645632

H3
Histone H3

1

0

High-throughput

0.426

High

645633

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

0

High-throughput

0.426

High

645634

CDC14
Tyrosine-protein phosphatase CDC14

1

0

High-throughput

0.426

High

645639

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.426

High

645646

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.426

High

645647

EAF1
Chromatin modification-related protein EAF1

1

0

High-throughput

0.426

High

645649

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.426

High

645651

TAF10
SAGA complex/transcription factor TFIID complex subunit TAF10

1

0

High-throughput

0.426

High

645613

SIT1
Siderophore iron transporter 1

2

0

Small-scale

0.330

High

645603

CACP
Carnitine O-acetyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

645618

NET1
Nucleolar protein NET1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025