Protein: ERG13
Hydroxymethylglutaryl-CoA synthase (HMG-CoA synthase) (EC 2.3.3.10) (3-hydroxy-3-methylglutaryl coenzyme A synthase)

Gene: ERG13
Organism: Saccharomyces cerevisiae S288C
Interactions: 70
UniProt ID: P54839

Gene Ontology (top 5):
GO:0004421 - hydroxymethylglutaryl-CoA synthase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0006084 - acetyl-CoA metabolic process
GO:0006696 - ergosterol biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780575

RRN3
RNA polymerase I-specific transcription initiation factor RRN3

2

0

High-throughput

0.595

High

524829

HSP71
Heat shock protein SSA1

2

2

High-throughput

0.571

High

825467

LYS12
Homoisocitrate dehydrogenase, mitochondrial

2

0

High-throughput

0.563

High

932651

ACT
Actin

2

0

High-throughput

0.563

High

850142

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

527415

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.552

High

545889

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.552

High

742167

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.552

High

819492

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

932654

RUVB1
RuvB-like protein 1

2

0

High-throughput

0.547

High

632196

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.518

High

660875

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

1

High-throughput

0.515

High

394808

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.513

High

511839

RS24A
Small ribosomal subunit protein eS24A

1

0

High-throughput

0.513

High

932652

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

591958

THRC
Threonine synthase

1

0

High-throughput

0.493

High

432665

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.489

High

932653

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.481

High

393162

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

579885

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

435280

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

594506

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

671007

SIS1
Protein SIS1

1

0

High-throughput

0.458

High

707889

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

709921

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

727239

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

735105

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

737921

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.458

High

750750

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

803646

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

806791

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

825809

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

918644

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

922641

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

932656

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

932657

SGO1
Shugoshin

1

0

High-throughput

0.458

High

932659

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

932660

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

932662

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

597241

BIP
Endoplasmic reticulum chaperone BiP

1

1

High-throughput

0.445

High

626848

HSP60
Heat shock protein 60, mitochondrial

1

1

High-throughput

0.445

High

453739

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

531843

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

592429

VATB
V-type proton ATPase subunit B

1

1

High-throughput

0.407

High

932661

RL7B
Large ribosomal subunit protein uL30B

1

1

High-throughput

0.407

High

531379

METK1
S-adenosylmethionine synthase 1

2

0

High-throughput

0.307

High

924810

CTU2
Cytoplasmic tRNA 2-thiolation protein 2

2

0

High-throughput

0.307

High

409769

RL24A
Large ribosomal subunit protein eL24A

1

0

High-throughput

0.279

Low

410276

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.279

Low

433267

RL17A
Large ribosomal subunit protein uL22A

1

0

High-throughput

0.279

Low

503180

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.279

Low

569842

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.279

Low

820941

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.279

Low

932655

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

932664

RS25A
Small ribosomal subunit protein eS25A

1

0

High-throughput

0.279

Low

455203

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

515304

RL35A
Large ribosomal subunit protein uL29A

1

0

High-throughput

0.249

Low

674771

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

778476

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

795144

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

795489

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

802319

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.249

Low

864801

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

932658

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

932663

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

386821

TBB
Tubulin beta chain

1

0

High-throughput

0.232

Low

734176

EF2
Elongation factor 2

1

0

High-throughput

0.232

Low

747518

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.232

Low

835861

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.232

Low

836839

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025