Protein: CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1 (Kinetochore-defect suppressor 4)

Gene: CUE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 42
UniProt ID: P38428

Gene Ontology (top 5):
GO:0000837 - Doa10p ubiquitin ligase complex
GO:0000839 - Hrd1p ubiquitin ligase ERAD-L complex
GO:0005739 - mitochondrion
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

799713

UBC7
Ubiquitin-conjugating enzyme E2 7

9

0

Small-scale

0.928

High

799705

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

5

0

Small-scale

0.682

High

509524

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

0

Small-scale

0.642

High

798639

SSH1
Sec sixty-one protein homolog

1

1

High-throughput

0.541

High

799701

YHE2
Putative uncharacterized protein YHL042W

1

1

High-throughput

0.541

High

799710

ERG25
C-4 methylsterol oxidase ERG25

1

1

High-throughput

0.541

High

416698

CAN1
Arginine permease CAN1

1

0

High-throughput

0.518

High

753686

TOM6
Mitochondrial import receptor subunit TOM6

1

0

High-throughput

0.518

High

754617

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

0

High-throughput

0.518

High

799707

GPI2
Phosphatidylinositol N-acetylglucosaminyltransferase GPI2 subunit

1

0

High-throughput

0.518

High

799708

SPC1
Signal peptidase complex subunit 1

1

0

High-throughput

0.518

High

799711

VPS73
Vacuolar protein sorting-associated protein 73

1

0

High-throughput

0.518

High

799700

COS8
Protein COS8

1

2

High-throughput

0.494

High

799704

UIP3
ULP1-interacting protein 3

1

2

High-throughput

0.494

High

799715

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

Small-scale

0.480

High

526568

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.479

High

735333

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

High-throughput

0.479

High

748370

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.479

High

448527

RHO1
GTP-binding protein RHO1

1

0

High-throughput

0.458

High

569402

DPM1
Dolichol-phosphate mannosyltransferase

1

0

High-throughput

0.458

High

798741

PHO89
Phosphate permease PHO89

1

0

High-throughput

0.458

High

799699

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

High-throughput

0.458

High

799717

ERP4
Protein ERP4

1

0

High-throughput

0.458

High

799718

ERG27
3-keto-steroid reductase ERG27

1

0

High-throughput

0.458

High

523795

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.437

High

799702

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

Small-scale

0.287

High

794374

MAL31
Maltose permease MAL31

1

0

High-throughput

0.282

High

799714

TPO1
Polyamine transporter 1

1

0

High-throughput

0.282

High

799716

POM34
Nucleoporin POM34

1

0

High-throughput

0.282

High

799709

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.269

Low

799706

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

444504

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

445336

CDC31
Cell division control protein 31

1

0

High-throughput

0.249

Low

452733

ADR1
Regulatory protein ADR1

1

0

High-throughput

0.249

Low

531719

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low

564781

ATN1
Sodium/potassium exporting P-type ATPase 1

1

0

High-throughput

0.249

Low

706965

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

750931

PRS7
26S proteasome regulatory subunit 7 homolog

1

0

Small-scale

0.249

Low

799703

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

799712

H3
Histone H3

1

0

High-throughput

0.249

Low

799719

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025