Protein: ERG27
3-keto-steroid reductase ERG27 (EC 1.1.1.270) (Ergosterol biosynthetic protein 27)

Gene: ERG27
Organism: Saccharomyces cerevisiae S288C
Interactions: 37
UniProt ID: Q12452

Gene Ontology (top 5):
GO:0000253 - 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005811 - lipid droplet

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1084937

ERG27
3-keto-steroid reductase ERG27

1

13

Small-scale

0.698

High

800453

ERG7
Lanosterol synthase ERG7

5

0

Small-scale

0.684

High

916791

ERG25
C-4 methylsterol oxidase ERG25

3

1

Small-scale

0.680

High

817338

ERG28
Ergosterol biosynthetic protein 28

3

0

Small-scale

0.647

High

673320

ADP1
Probable ATP-dependent permease

1

5

High-throughput

0.568

High

1084107

CDC53
Cell division control protein 53

2

2

Small-scale

0.543

High

528651

CP51
Lanosterol 14-alpha demethylase CYP51

1

2

Small-scale

0.541

High

672180

ERG4
Delta(24(24(1)))-sterol reductase ERG4

1

2

Small-scale

0.541

High

715053

ERG9
Squalene synthase ERG9

1

1

Small-scale

0.541

High

735365

ERG3
Delta(7)-sterol 5(6)-desaturase ERG3

1

1

Small-scale

0.541

High

737167

ERG24
Delta(14)-sterol reductase ERG24

1

2

Small-scale

0.541

High

796241

FAT1
Very long-chain fatty acid transport protein

1

3

High-throughput

0.541

High

918154

ERG26
Sterol-4-alpha-carboxylate 3-dehydrogenase ERG26, decarboxylating

1

3

Small-scale

0.541

High

932193

ERG5
C-22 sterol desaturase ERG5

1

3

Small-scale

0.541

High

668973

ERG6
Sterol 24-C-methyltransferase ERG6

1

0

Small-scale

0.518

High

1060069

YEH1
Sterol esterase 1

1

0

High-throughput

0.518

High

1046656

MYO5
Myosin-5

1

4

Small-scale

0.504

High

836127

COPB2
Coatomer subunit beta'

1

3

High-throughput

0.489

High

748792

YPT7
Ypt/Rab-type GTPase YPT7

1

6

Small-scale

0.479

High

1084938

ENV10
SRP-independent targeting protein 2

1

3

High-throughput

0.479

High

797092

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

799718

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

1

0

High-throughput

0.458

High

1035220

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.457

High

671269

SIS1
Protein SIS1

1

1

High-throughput

0.437

High

737974

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.437

High

795287

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

528089

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.407

High

820190

SSB2
Ribosome-associated molecular chaperone SSB2

1

8

High-throughput

0.407

High

903545

PDR10
ATP-dependent permease PDR10

1

0

High-throughput

0.296

High

571859

SNA3
Protein SNA3

1

0

High-throughput

0.282

High

1084529

ENG2
Glucan endo-1,3-beta-D-glucosidase 2

1

0

High-throughput

0.282

High

708604

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

812789

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

877946

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

1040564

ESP1
Separin

1

0

High-throughput

0.249

Low

395031

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025