HitPredict

Interactor 1: LDB1 (P70662)
LIM domain-binding protein 1 (LDB-1) (Carboxyl-terminal LIM domain-binding protein 2) (CLIM-2) (LIM domain-binding factor CLIM2) (mLdb1) (Nuclear LIM interactor)
Gene: LDB1

Interactor 2: LMX1A (Q9JKU8)
LIM homeobox transcription factor 1-alpha (LIM/homeobox protein 1.1) (LMX-1.1) (LIM/homeobox protein LMX1A)
Gene: LMX1A

Species: Mus musculus

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.48	1.00	0.698

Property	Details
Experiments	20211142
Identification Methods	two hybrid, two hybrid array
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	LID~LIM
Common GO terms	GO:0005634 - nucleus GO:0021549 - cerebellum development GO:0045944 - positive regulation of transcription by RNA polymerase II
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 411 Mm			1 382
+	Hs
		253019 LDB1_HUMAN (1-411): 0: 760: 99.76		LMX1B_HUMAN (1-382): 6.51e-89: 275: 65.38
+	Mm
		312694 LDB1_MOUSE (1-411): 0: 760: 100.00		LMX1B_MOUSE (1-382): 1.5e-83: 261: 63.82
+	Hs
		1287935 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX3_HUMAN (7-377): 1.91e-71: 230: 27.66
+	Mm
		895873 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX3_MOUSE (7-377): 2.52e-68: 222: 27.70
+	Mm
		961503 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX5_MOUSE (34-381): 3.22e-68: 222: 26.70
+	Hs
		1287917 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX4_HUMAN (6-343): 7.47e-67: 218: 29.33
+	Mm
		988942 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX1_MOUSE (34-381): 1.45e-66: 218: 29.03
+	Hs
		877527 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX1_HUMAN (34-381): 3.12e-66: 217: 29.03
+	Mm
		923325 LDB1_MOUSE (1-411): 0: 760: 100.00		LHX4_MOUSE (6-343): 1.3e-66: 217: 29.33
+	Hs
		1287932 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX9_HUMAN (1-317): 3.69e-66: 216: 25.50
+	Hs
		895744 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX2_HUMAN (13-324): 1.19e-63: 210: 25.75
+	Hs
		961481 LDB1_HUMAN (1-411): 0: 760: 99.76		ISL1_HUMAN (33-361): 3.12e-64: 210: 28.40
+	Mm
		961497 LDB1_MOUSE (1-411): 0: 760: 100.00		ISL1_MOUSE (33-361): 3.12e-64: 210: 28.40
+	Hs
		1287918 LDB1_HUMAN (1-411): 0: 760: 99.76		ISL2_HUMAN (23-361): 1.28e-63: 209: 29.31
+	Hs
		1229355 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX8_HUMAN (30-322): 1.3e-54: 185: 27.46
+	Hs
		1287938 LDB1_HUMAN (1-411): 0: 760: 99.76		LHX6_HUMAN (11-350): 1.8e-53: 182: 27.33
+	Mm
		1000512 LDB1_MOUSE (1-411): 0: 760: 100.00		RBTN1_MOUSE (35-152): 9.1e-51: 169: 39.84
+	Hs
		682055 LDB1_HUMAN (1-411): 0: 760: 99.76		RBTN1_HUMAN (35-150): 1.73e-50: 168: 40.50
+	Mm
		1000507 LDB1_MOUSE (1-411): 0: 760: 100.00		LMO3_MOUSE (35-150): 5.15e-50: 166: 41.32
+	Hs
		1287915 LDB1_HUMAN (1-411): 0: 760: 99.76		LMO3_HUMAN (35-150): 8.09e-26: 103: 41.32