HitPredict

Interactor 1: DLK1 (P80370)
Protein delta homolog 1 (DLK-1) (pG2) [Cleaved into: Fetal antigen 1 (FA1)]
Gene: DLK1

Interactor 2: ITCH (Q96J02)
E3 ubiquitin-protein ligase Itchy homolog (Itch) (EC 2.3.2.26) (Atrophin-1-interacting protein 4) (AIP4) (HECT-type E3 ubiquitin transferase Itchy homolog) (NFE2-associated polypeptide 1) (NAPP1)
Gene: ITCH

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0016020 - membrane
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 383 Hs			1 903
+	Hs
		1010102 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		857533 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Hs
		1008021 JAG1_HUMAN (114-347): 7.46e-17: 84.4: 15.75		ITCH_HUMAN (1-903): 0: 913: 100.00
+	Mm
		1032088 NOTC1_MOUSE (7-312): 1.23e-12: 71.7: 16.99		ITCH_MOUSE (1-903): 0: 872: 91.16
+	Hs
		857554 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		WWP1_HUMAN (1-903): 0: 837: 57.00
+	Hs
		132372 NOTC3_HUMAN (22-244): 1.95e-17: 86.7: 31.37		WWP2_HUMAN (1-903): 0: 808: 54.18
+	Hs
		861562 DLK1_HUMAN (1-383): 1.56e-69: 224: 100.00		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Dm
		451975 NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77		SUDX_DROME (18-903): 0: 785: 48.62
+	Hs
		857539 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		NED4L_HUMAN (6-900): 0: 761: 32.31
+	Dm
		263208 TENM_DROME (207-350): 2.04e-15: 80.2: 12.50		NEDD4_DROME (3-901): 0: 729: 29.38
+	Dm
		451922 NOTCH_DROME (8-297): 1.74e-14: 77.5: 18.77		NEDD4_DROME (3-901): 0: 729: 29.38
+	Hs
		857371 NOTC1_HUMAN (6-244): 2.16e-22: 101: 27.00		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		861657 FAT4_HUMAN (57-157): 5.13e-11: 66.7: 23.76		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		861610 FAT1_HUMAN (10-60): 1.58e-09: 62.1: 16.07		NEDD4_HUMAN (90-900): 0: 670: 34.16
+	Hs
		317575 SLIT2_HUMAN (209-331): 1.8e-09: 61.7: 14.29		HUWE1_HUMAN (415-902): 8.1e-162: 527: 34.88
+	Dm
		263321 TENM_DROME (207-350): 2.04e-15: 80.2: 12.50		Q9W325_DROME (496-903): 1.16e-170: 504: 46.38
+	Dm
		262945 TENM_DROME (207-350): 2.04e-15: 80.2: 12.50		SMUF1_DROME (16-443): 2.43e-27: 121: 13.53